Characterization of radical types, penetration profile and distribution pattern of the topically applied photosensitizer THPTS in porcine skin ex vivo

•The main penetration of the photosensitizer THPTS into the skin occurs up to 10 min incubation time.•A penetration time >10 min promotes the loss of functionality of THPTS.•An irradiation between 400 and 700 nm is needed to activate THPTS in order to develop its effect as photosensitizer.•During...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2021-05, Vol.162, p.50-58
Hauptverfasser:	Lohan, S.B., Kröger, M., Schleusener, J., Darvin, M.E., Lademann, J., Streit, I., Meinke, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Confocal Raman microspectroscopy (CRM) Electron paramagnetic resonance (EPR) spectroscopy Fluorescence lifetime imaging Photodynamic therapy (PDT) Photosensitizer Stratum corneum Tetrahydroporphyrin-Tetratosylat (THPTS) Two-photon tomography
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