Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules

Lysophosphatidic acid (LPA) acts through the activation of G protein-coupled receptors, in a Ca 2+ -dependent manner. We show the effects of LPA on the plasma membrane Ca 2+ -ATPase (PMCA) from kidney proximal tubule cells. The Ca 2+ -ATPase activity was inhibited by nanomolar concentrations of LPA,...

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Veröffentlicht in:	Journal of physiology and biochemistry 2021-05, Vol.77 (2), p.321-329
Hauptverfasser:	Sant’Anna, Julliana F., Baldez, Vanessa S., Razuck-Garrão, Natalie A., Lemos, Thiago, Diaz, Bruno L., Einicker-Lamas, Marcelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animal Physiology Biomedical and Life Sciences Biomedicine Ca2+-transporting ATPase Calcium (intracellular) Calcium ions G protein-coupled receptors Human Physiology Kidneys Lipids Lysophosphatidic acid Membranes Original Article Phosphorylation Protein kinase C Proximal tubules Receptors Sodium
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