Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey
This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance. Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiol...
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Veröffentlicht in: | Journal of infection in developing countries 2021-03, Vol.15 (2), p.254-262 |
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description | This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance.
Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST.
Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were Acinetobacter spp. (27.4%), P.aeruginosa (22.2%), K.pneumoniae (17.9%); among CA pathogen S.pneumoniae (19.9%), P. aeruginosa (18.9%), H.influenzae (14.6%). ESBL rate was 62.5% in K.penumoniae; 53.1% in E.coli; 19.1% in Klebsiella spp; 13.9% in Enterobacter spp.; 8.6% in Proteus spp.; 6.3% in Citrobacter spp.; and 4.3% in Serratia spp. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in A baumannii, 39.8% and 7.5% in P.aeruginosa, 47.3% and 18.5% in K.penumoniae. Among staphylococci, 27.3% of S. aureus and 82.4% of CoNS were methicillin resistant. 7.6% of E.faecium and 0.9% of E.faecalis were vancomycin resistant. Linezolid resistant S. aureus, CoNS, E.faecalis and E.faecium rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in S. aureus 38.2% in CoNS. Non-susceptible S.pneumoniae isolate rate to penicillin was 37.0%. 6.5% of S.maltophilia and 4.4% of B.cepacia isolates were resistant to trimethoprim/sulfamethoxazole.
Antibiotic resistance was mainly observed among A.baumannii and K.pneumoniae and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important. |
doi_str_mv | 10.3855/jidc.12599 |
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Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST.
Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were Acinetobacter spp. (27.4%), P.aeruginosa (22.2%), K.pneumoniae (17.9%); among CA pathogen S.pneumoniae (19.9%), P. aeruginosa (18.9%), H.influenzae (14.6%). ESBL rate was 62.5% in K.penumoniae; 53.1% in E.coli; 19.1% in Klebsiella spp; 13.9% in Enterobacter spp.; 8.6% in Proteus spp.; 6.3% in Citrobacter spp.; and 4.3% in Serratia spp. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in A baumannii, 39.8% and 7.5% in P.aeruginosa, 47.3% and 18.5% in K.penumoniae. Among staphylococci, 27.3% of S. aureus and 82.4% of CoNS were methicillin resistant. 7.6% of E.faecium and 0.9% of E.faecalis were vancomycin resistant. Linezolid resistant S. aureus, CoNS, E.faecalis and E.faecium rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in S. aureus 38.2% in CoNS. Non-susceptible S.pneumoniae isolate rate to penicillin was 37.0%. 6.5% of S.maltophilia and 4.4% of B.cepacia isolates were resistant to trimethoprim/sulfamethoxazole.
Antibiotic resistance was mainly observed among A.baumannii and K.pneumoniae and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important.</description><identifier>ISSN: 1972-2680</identifier><identifier>ISSN: 2036-6590</identifier><identifier>EISSN: 1972-2680</identifier><identifier>DOI: 10.3855/jidc.12599</identifier><identifier>PMID: 33690209</identifier><language>eng</language><publisher>Italy: Journal of Infection in Developing Countries</publisher><subject>Antibiotics ; Drug resistance ; Pathogens</subject><ispartof>Journal of infection in developing countries, 2021-03, Vol.15 (2), p.254-262</ispartof><rights>Copyright (c) 2021 Aylin Uskudar Guclu, Aylin Altay Kocak, Mehtap Akcil Ok, Bulent Tutluoglu, Ahmet Celal Basustaoglu.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-6f500eb3c2947b96c2e189b3673c6855d919b847ba70d6833f4f541ebc1536803</citedby><orcidid>0000-0002-2571-0637 ; 0000-0002-1872-028X ; 0000-0002-0451-0142 ; 0000-0002-1793-8092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33690209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uskudar Guclu, Aylin</creatorcontrib><creatorcontrib>Altay Kocak, Aylin</creatorcontrib><creatorcontrib>Akcil Ok, Mehtap</creatorcontrib><creatorcontrib>Tutluoglu, Bulent</creatorcontrib><creatorcontrib>Basustaoglu, Ahmet Celal</creatorcontrib><creatorcontrib>Respiratory Study Group</creatorcontrib><title>Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey</title><title>Journal of infection in developing countries</title><addtitle>J Infect Dev Ctries</addtitle><description>This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance.
Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST.
Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were Acinetobacter spp. (27.4%), P.aeruginosa (22.2%), K.pneumoniae (17.9%); among CA pathogen S.pneumoniae (19.9%), P. aeruginosa (18.9%), H.influenzae (14.6%). ESBL rate was 62.5% in K.penumoniae; 53.1% in E.coli; 19.1% in Klebsiella spp; 13.9% in Enterobacter spp.; 8.6% in Proteus spp.; 6.3% in Citrobacter spp.; and 4.3% in Serratia spp. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in A baumannii, 39.8% and 7.5% in P.aeruginosa, 47.3% and 18.5% in K.penumoniae. Among staphylococci, 27.3% of S. aureus and 82.4% of CoNS were methicillin resistant. 7.6% of E.faecium and 0.9% of E.faecalis were vancomycin resistant. Linezolid resistant S. aureus, CoNS, E.faecalis and E.faecium rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in S. aureus 38.2% in CoNS. Non-susceptible S.pneumoniae isolate rate to penicillin was 37.0%. 6.5% of S.maltophilia and 4.4% of B.cepacia isolates were resistant to trimethoprim/sulfamethoxazole.
Antibiotic resistance was mainly observed among A.baumannii and K.pneumoniae and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important.</description><subject>Antibiotics</subject><subject>Drug resistance</subject><subject>Pathogens</subject><issn>1972-2680</issn><issn>2036-6590</issn><issn>1972-2680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkV1LwzAUhoMobk5v_AES8EaEznw0aeNdHX7BRJF5XdI01Wz9mEmL9N-bujnEq3M45-HlvOcF4BSjKY0Zu1qaXE0xYULsgTEWEQkIj9H-n34EjpxbIsQEZfgQjCjlAhEkxmCV1K3JpGq1NbKEr9oZ18paaWhqOG--tB1ma2Nl29geLqxH4c2Of5HtR_Oua3cNE_jUla1RuvY7mNSy7L0WLGxTwUVnV7o_BgeFLJ0-2dYJeLu7Xcwegvnz_eMsmQeKYtYGvGAI6YwqIsIoE1wRjWORUR5Rxb3fXGCRxX4lI5TzmNIiLFiIdaYwo94snYCLje7aNp-ddm1aGad0WcpaN51LidenUUhQ5NHzf-iy6ay_faA4QoITPFCXG0rZxjmri3RtTSVtn2KUDhGkQwTpTwQePttKdlml8x36-3P6DRXqgTU</recordid><startdate>20210307</startdate><enddate>20210307</enddate><creator>Uskudar Guclu, Aylin</creator><creator>Altay Kocak, Aylin</creator><creator>Akcil Ok, Mehtap</creator><creator>Tutluoglu, Bulent</creator><creator>Basustaoglu, Ahmet Celal</creator><general>Journal of Infection in Developing Countries</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2571-0637</orcidid><orcidid>https://orcid.org/0000-0002-1872-028X</orcidid><orcidid>https://orcid.org/0000-0002-0451-0142</orcidid><orcidid>https://orcid.org/0000-0002-1793-8092</orcidid></search><sort><creationdate>20210307</creationdate><title>Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey</title><author>Uskudar Guclu, Aylin ; Altay Kocak, Aylin ; Akcil Ok, Mehtap ; Tutluoglu, Bulent ; Basustaoglu, Ahmet Celal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-6f500eb3c2947b96c2e189b3673c6855d919b847ba70d6833f4f541ebc1536803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotics</topic><topic>Drug resistance</topic><topic>Pathogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uskudar Guclu, Aylin</creatorcontrib><creatorcontrib>Altay Kocak, Aylin</creatorcontrib><creatorcontrib>Akcil Ok, Mehtap</creatorcontrib><creatorcontrib>Tutluoglu, Bulent</creatorcontrib><creatorcontrib>Basustaoglu, Ahmet Celal</creatorcontrib><creatorcontrib>Respiratory Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uskudar Guclu, Aylin</au><au>Altay Kocak, Aylin</au><au>Akcil Ok, Mehtap</au><au>Tutluoglu, Bulent</au><au>Basustaoglu, Ahmet Celal</au><aucorp>Respiratory Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey</atitle><jtitle>Journal of infection in developing countries</jtitle><addtitle>J Infect Dev Ctries</addtitle><date>2021-03-07</date><risdate>2021</risdate><volume>15</volume><issue>2</issue><spage>254</spage><epage>262</epage><pages>254-262</pages><issn>1972-2680</issn><issn>2036-6590</issn><eissn>1972-2680</eissn><abstract>This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance.
Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST.
Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were Acinetobacter spp. (27.4%), P.aeruginosa (22.2%), K.pneumoniae (17.9%); among CA pathogen S.pneumoniae (19.9%), P. aeruginosa (18.9%), H.influenzae (14.6%). ESBL rate was 62.5% in K.penumoniae; 53.1% in E.coli; 19.1% in Klebsiella spp; 13.9% in Enterobacter spp.; 8.6% in Proteus spp.; 6.3% in Citrobacter spp.; and 4.3% in Serratia spp. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in A baumannii, 39.8% and 7.5% in P.aeruginosa, 47.3% and 18.5% in K.penumoniae. Among staphylococci, 27.3% of S. aureus and 82.4% of CoNS were methicillin resistant. 7.6% of E.faecium and 0.9% of E.faecalis were vancomycin resistant. Linezolid resistant S. aureus, CoNS, E.faecalis and E.faecium rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in S. aureus 38.2% in CoNS. Non-susceptible S.pneumoniae isolate rate to penicillin was 37.0%. 6.5% of S.maltophilia and 4.4% of B.cepacia isolates were resistant to trimethoprim/sulfamethoxazole.
Antibiotic resistance was mainly observed among A.baumannii and K.pneumoniae and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important.</abstract><cop>Italy</cop><pub>Journal of Infection in Developing Countries</pub><pmid>33690209</pmid><doi>10.3855/jidc.12599</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2571-0637</orcidid><orcidid>https://orcid.org/0000-0002-1872-028X</orcidid><orcidid>https://orcid.org/0000-0002-0451-0142</orcidid><orcidid>https://orcid.org/0000-0002-1793-8092</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antibiotics Drug resistance Pathogens |
title | Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey |
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