Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development
The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still lim...
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| Veröffentlicht in: | Biology of reproduction 2021-06, Vol.104 (6), p.1249-1261 |
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| container_title | Biology of reproduction |
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| creator | Harwalkar, Keerthana Ford, Matthew J. Teng, Katie Yamanaka, Nobuko Yang, Brenna Burtscher, Ingo Lickert, Heiko Yamanaka, Yojiro |
| description | The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla–isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction. Summary sentence: The mouse oviduct mucosal epithelium has highly diverse structures with 7 distinct epithelial cell populations, likely reflecting its complex functions in reproduction. Graphical Abstract |
| doi_str_mv | 10.1093/biolre/ioab043 |
| format | Article |
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It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla–isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction. Summary sentence: The mouse oviduct mucosal epithelium has highly diverse structures with 7 distinct epithelial cell populations, likely reflecting its complex functions in reproduction. Graphical Abstract</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1093/biolre/ioab043</identifier><identifier>PMID: 33693543</identifier><language>eng</language><publisher>United States: Society for the Study of Reproduction</publisher><subject>Animals ; Cancer ; Diabetes ; Embryonic Development ; Embryos ; Epithelial cells ; Epithelium ; Fallopian tube ; Fallopian tubes ; Female ; Fertilization ; Gene expression ; Medical research ; Mice ; Morphology ; Mucosa ; mucosal epithelium ; mucosal folds ; Ovaries ; Oviduct ; Oviducts - anatomy & histology ; Oviducts - cytology ; Pregnancy ; preimplantation embryo development ; Reproduction ; Reproductive organs ; RESEARCH ARTICLE ; Smooth muscle ; Sperm ; sperm reservoir ; Uterus</subject><ispartof>Biology of reproduction, 2021-06, Vol.104 (6), p.1249-1261</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com journals.permissions@oup.com</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b501t-d5fd2136fc2d79d9eae5d40f8318dc11657ae19168e75a3525ad169284d071013</citedby><cites>FETCH-LOGICAL-b501t-d5fd2136fc2d79d9eae5d40f8318dc11657ae19168e75a3525ad169284d071013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33693543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harwalkar, Keerthana</creatorcontrib><creatorcontrib>Ford, Matthew J.</creatorcontrib><creatorcontrib>Teng, Katie</creatorcontrib><creatorcontrib>Yamanaka, Nobuko</creatorcontrib><creatorcontrib>Yang, Brenna</creatorcontrib><creatorcontrib>Burtscher, Ingo</creatorcontrib><creatorcontrib>Lickert, Heiko</creatorcontrib><creatorcontrib>Yamanaka, Yojiro</creatorcontrib><title>Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla–isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction. Summary sentence: The mouse oviduct mucosal epithelium has highly diverse structures with 7 distinct epithelial cell populations, likely reflecting its complex functions in reproduction. Graphical Abstract</description><subject>Animals</subject><subject>Cancer</subject><subject>Diabetes</subject><subject>Embryonic Development</subject><subject>Embryos</subject><subject>Epithelial cells</subject><subject>Epithelium</subject><subject>Fallopian tube</subject><subject>Fallopian tubes</subject><subject>Female</subject><subject>Fertilization</subject><subject>Gene expression</subject><subject>Medical research</subject><subject>Mice</subject><subject>Morphology</subject><subject>Mucosa</subject><subject>mucosal epithelium</subject><subject>mucosal folds</subject><subject>Ovaries</subject><subject>Oviduct</subject><subject>Oviducts - anatomy & histology</subject><subject>Oviducts - cytology</subject><subject>Pregnancy</subject><subject>preimplantation embryo development</subject><subject>Reproduction</subject><subject>Reproductive organs</subject><subject>RESEARCH ARTICLE</subject><subject>Smooth muscle</subject><subject>Sperm</subject><subject>sperm reservoir</subject><subject>Uterus</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc9KHTEYxUOp1FvbbZdloBsLjib5JvNneZG2CkI37TrkTr7RSCaZJhnBnQ_hE_okzXhvK4ggWQQOv3M4ySHkE6PHjHZwsjHeBjwxXm1oBW_IignelQ2v27dkRSmtS4Aa9sn7GK8pZRVweEf2s9aBqGBF7tZOJT-aXtlCOV30aO1sVSiuMGHwl-jQpNvCuCJdYTH6OWLhb4ye-_Rwd29SLCaf0CWT_cFbjAsacAp-QYx3j6lTQDNOVrmkHjWNN2j9NGbjB7I3KBvx4-4-IL-_f_t1elZe_Pxxfrq-KDeCslRqMWjOoB56rptOd6hQ6IoOLbBW94zVolHIOla32AgFggulWd3xttK0YZTBATnc5uZqf2aMSY4mLq9VDvOrJBeUQgMtX9Avz9BrPweX22WqaTlUINon6lJZlMYNPgXVL6Fy3VDWceAVz9TxC1Q-GvOne4eDyfpLhj74GAMOcgpmVOFWMiqXyeV2crmbPBs-79rOmxH1f_zfxhn4ugX8PL0edrRls57LvYb_BbPLyHA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Harwalkar, Keerthana</creator><creator>Ford, Matthew J.</creator><creator>Teng, Katie</creator><creator>Yamanaka, Nobuko</creator><creator>Yang, Brenna</creator><creator>Burtscher, Ingo</creator><creator>Lickert, Heiko</creator><creator>Yamanaka, Yojiro</creator><general>Society for the Study of Reproduction</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development</title><author>Harwalkar, Keerthana ; 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It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla–isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction. Summary sentence: The mouse oviduct mucosal epithelium has highly diverse structures with 7 distinct epithelial cell populations, likely reflecting its complex functions in reproduction. Graphical Abstract</abstract><cop>United States</cop><pub>Society for the Study of Reproduction</pub><pmid>33693543</pmid><doi>10.1093/biolre/ioab043</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biology of reproduction, 2021-06, Vol.104 (6), p.1249-1261 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Cancer Diabetes Embryonic Development Embryos Epithelial cells Epithelium Fallopian tube Fallopian tubes Female Fertilization Gene expression Medical research Mice Morphology Mucosa mucosal epithelium mucosal folds Ovaries Oviduct Oviducts - anatomy & histology Oviducts - cytology Pregnancy preimplantation embryo development Reproduction Reproductive organs RESEARCH ARTICLE Smooth muscle Sperm sperm reservoir Uterus |
| title | Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development |
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