Milk Fat Globule Membrane Supplementation During Suckling Ameliorates Maternal High Fat Diet–Induced Hepatic Steatosis in Adult Male Offspring of Mice

Exposure to a maternal high-fat diet (HFD) predisposes offspring to nonalcoholic fatty liver disease. The aim of this study was to explore whether milk fat globule membrane (MFGM) supplementation during suckling exerts a long-term protective effect on hepatic lipid metabolism in adult offspring expo...

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Veröffentlicht in:	The Journal of nutrition 2021-06, Vol.151 (6), p.1487-1496
Hauptverfasser:	Zhang, Qianren, Ye, Lin, Xin, Fengzhi, Zhou, Jiefei, Cao, Baige, Dong, Yan, Qian, Linxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine kinase Adenosine monophosphate AKT protein AMP Animal fat Animals Antioxidants Aspartate aminotransferase Aspartate Aminotransferases - blood Blood Glucose Body weight Breastfeeding & lactation Diet Diet, High-Fat - adverse effects Dietary Supplements Fatty liver Fatty Liver - prevention & control Female Gestation Glycolipids - administration & dosage Glycoproteins - administration & dosage hepatic steatosis High fat diet Histopathology Kinases Kruskal-Wallis test Lactation Lipid Droplets Lipid metabolism Lipids Lipogenesis Liver Liver diseases liver mitochondria Male Males Malondialdehyde Maternal Nutritional Physiological Phenomena Membranes metabolic programming Metabolism Mice Mice, Inbred C57BL Milk milk fat globule membrane Milk fat globule membranes Mitochondria Nutrition Offspring Oxidative stress Parameters Protein kinase Rapamycin Steatosis Suckling behavior Superoxide dismutase Triglycerides Triglycerides - analysis Variance analysis
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