Implication of efflux pumps and ERG11 genes in resistance of clinical Trichosporon asahii isolates to fluconazole

has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Molecular mechanisms of azole resistance have been rarely reported for . Similar to other fungi, we hypothesized that both gene mutation and efflux pumps genes hyper-expression were implicated. The cu...

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Veröffentlicht in:	Journal of medical microbiology 2021-03, Vol.70 (3)
Hauptverfasser:	Abbes, S, Sellami, H, Neji, S, Trabelsi, H, Makni, F, Ayadi, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Antifungal Agents - pharmacology Basidiomycota - drug effects Basidiomycota - genetics Cytochrome P-450 Enzyme System - genetics Drug Resistance, Fungal - genetics Fluconazole - pharmacology Fungal Proteins - genetics Humans Trichosporonosis - microbiology Voriconazole - pharmacology
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