Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio
Purpose To evaluate the overall survival prognostic value of preoperative 18 F-fluorodeoxyglucose positron emission tomography (PET) in breast cancer, as compared with the lymph node ratio (LNR). Methods Data were abstracted at a median follow-up 14.7 years from a retrospective cohort of 104 patient...
Gespeichert in:
| Veröffentlicht in: | Breast cancer (Tokyo, Japan) Japan), 2021-07, Vol.28 (4), p.956-968 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 968 |
|---|---|
| container_issue | 4 |
| container_start_page | 956 |
| container_title | Breast cancer (Tokyo, Japan) |
| container_volume | 28 |
| creator | Vinh-Hung, Vincent Everaert, Hendrik Gorobets, Olena Van Parijs, Hilde Verfaillie, Guy Vanhoeij, Marian Storme, Guy Fontaine, Christel Lamote, Jan Perrin, Justine Farid, Karim Nguyen, Nam P. Verschraegen, Claire De Ridder, Mark |
| description | Purpose
To evaluate the overall survival prognostic value of preoperative
18
F-fluorodeoxyglucose positron emission tomography (PET) in breast cancer, as compared with the lymph node ratio (LNR).
Methods
Data were abstracted at a median follow-up 14.7 years from a retrospective cohort of 104 patients who underwent PET imaging before curative surgery. PET-Axillary|Sternal was classified as PET-positive if hypermetabolism was visualized in ipsilateral nodal axillary and/or sternal region, else as PET-negative. The differences of 15 years restricted mean survival time
∆
RMST
according to PET and LNR were computed from Kaplan–Meier overall survival. The effect of PET and other patients' characteristics was analyzed through rankit normalization, which provides with Cox regression the Royston–Sauerbrei
D
measure of separation to compare the characteristics (0 indicating no prognostic value). Multivariate analysis of the normalized characteristics used stepwise selection with the Akaike information criterion.
Results
In Kaplan–Meier analysis, LNR > 0.20 versus ≤ 0.20 showed
∆
RMST
= 3.4 years,
P
= 0.003. PET-Axillary|Sternal positivity versus PET-negative showed a
∆
RMST
= 2.6 years,
P
= 0.008. In Cox univariate analyses, LNR appeared as topmost prognostic separator,
D
= 1.50,
P
|
| doi_str_mv | 10.1007/s12282-021-01234-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2499930509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2499930509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-d863db78e5871978cd2a472a5d003721616817c1b2140e786e2ba2f7508a0d963</originalsourceid><addsrcrecordid>eNp9kE1PwzAMhisEEmPwBzjlyIGAk3RNeuRjG0iT4DDOUZZ6W6e2KUk3tP16spUzJ1vW81r2kyS3DB4YgHwMjHPFKXBGgXGR0sNZMmBKAU25EOexFynQTGXqMrkKYQOQCgnZIHHPHk3oiDWNRU9aj65Fb7pyh4SpyeuUfo7n98Tt4rCqSNj6XbkzVQTdqnGhKy0J2JpjwjXEujr2WJCfsluTbo2k2tftmjSuQHJirpOLpakC3vzVYfI1Gc9f3ujsY_r-8jSjVnDe0UJlolhIhSMlWS6VLbhJJTejAkBIzjKWKSYtW3CWAkqVIV8YvpQjUAaKPBPD5K7fGw_93mLodF0Gi1VlGnTboHma57mAEeQR5T1qvQvB41K3vqyN32sG-mhX93Z1tKtPdvUhhkQfChFuVuj1xm19E1_6L_ULE6h90Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2499930509</pqid></control><display><type>article</type><title>Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio</title><source>Springer Nature - Complete Springer Journals</source><creator>Vinh-Hung, Vincent ; Everaert, Hendrik ; Gorobets, Olena ; Van Parijs, Hilde ; Verfaillie, Guy ; Vanhoeij, Marian ; Storme, Guy ; Fontaine, Christel ; Lamote, Jan ; Perrin, Justine ; Farid, Karim ; Nguyen, Nam P. ; Verschraegen, Claire ; De Ridder, Mark</creator><creatorcontrib>Vinh-Hung, Vincent ; Everaert, Hendrik ; Gorobets, Olena ; Van Parijs, Hilde ; Verfaillie, Guy ; Vanhoeij, Marian ; Storme, Guy ; Fontaine, Christel ; Lamote, Jan ; Perrin, Justine ; Farid, Karim ; Nguyen, Nam P. ; Verschraegen, Claire ; De Ridder, Mark</creatorcontrib><description>Purpose
To evaluate the overall survival prognostic value of preoperative
18
F-fluorodeoxyglucose positron emission tomography (PET) in breast cancer, as compared with the lymph node ratio (LNR).
Methods
Data were abstracted at a median follow-up 14.7 years from a retrospective cohort of 104 patients who underwent PET imaging before curative surgery. PET-Axillary|Sternal was classified as PET-positive if hypermetabolism was visualized in ipsilateral nodal axillary and/or sternal region, else as PET-negative. The differences of 15 years restricted mean survival time
∆
RMST
according to PET and LNR were computed from Kaplan–Meier overall survival. The effect of PET and other patients' characteristics was analyzed through rankit normalization, which provides with Cox regression the Royston–Sauerbrei
D
measure of separation to compare the characteristics (0 indicating no prognostic value). Multivariate analysis of the normalized characteristics used stepwise selection with the Akaike information criterion.
Results
In Kaplan–Meier analysis, LNR > 0.20 versus ≤ 0.20 showed
∆
RMST
= 3.4 years,
P
= 0.003. PET-Axillary|Sternal positivity versus PET-negative showed a
∆
RMST
= 2.6 years,
P
= 0.008. In Cox univariate analyses, LNR appeared as topmost prognostic separator,
D
= 1.50,
P
< 0.001. PET ranked below but was also highly significant,
D
= 1.02,
P
= 0.009. In multivariate analyses, LNR and PET-Axillary|Sternal were colinear and mutually exclusive. PET-Axillary|Sternal improved as prognosticator in a model excluding lymph nodes, yielding a normalized hazard ratio of 2.44,
P
= 0.062.
Conclusion
Pathological lymph node assessment remains the gold standard of prognosis. However, PET appears as a valuable surrogate in univariate analysis at 15-year follow-up. There was a trend towards significance in multivariate analysis that warrants further investigation.</description><identifier>ISSN: 1340-6868</identifier><identifier>ISSN: 1880-4233</identifier><identifier>EISSN: 1880-4233</identifier><identifier>DOI: 10.1007/s12282-021-01234-z</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Cancer Research ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Surgery ; Surgical Oncology</subject><ispartof>Breast cancer (Tokyo, Japan), 2021-07, Vol.28 (4), p.956-968</ispartof><rights>The Japanese Breast Cancer Society 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-d863db78e5871978cd2a472a5d003721616817c1b2140e786e2ba2f7508a0d963</citedby><cites>FETCH-LOGICAL-c322t-d863db78e5871978cd2a472a5d003721616817c1b2140e786e2ba2f7508a0d963</cites><orcidid>0000-0002-6403-6120</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12282-021-01234-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12282-021-01234-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Vinh-Hung, Vincent</creatorcontrib><creatorcontrib>Everaert, Hendrik</creatorcontrib><creatorcontrib>Gorobets, Olena</creatorcontrib><creatorcontrib>Van Parijs, Hilde</creatorcontrib><creatorcontrib>Verfaillie, Guy</creatorcontrib><creatorcontrib>Vanhoeij, Marian</creatorcontrib><creatorcontrib>Storme, Guy</creatorcontrib><creatorcontrib>Fontaine, Christel</creatorcontrib><creatorcontrib>Lamote, Jan</creatorcontrib><creatorcontrib>Perrin, Justine</creatorcontrib><creatorcontrib>Farid, Karim</creatorcontrib><creatorcontrib>Nguyen, Nam P.</creatorcontrib><creatorcontrib>Verschraegen, Claire</creatorcontrib><creatorcontrib>De Ridder, Mark</creatorcontrib><title>Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio</title><title>Breast cancer (Tokyo, Japan)</title><addtitle>Breast Cancer</addtitle><description>Purpose
To evaluate the overall survival prognostic value of preoperative
18
F-fluorodeoxyglucose positron emission tomography (PET) in breast cancer, as compared with the lymph node ratio (LNR).
Methods
Data were abstracted at a median follow-up 14.7 years from a retrospective cohort of 104 patients who underwent PET imaging before curative surgery. PET-Axillary|Sternal was classified as PET-positive if hypermetabolism was visualized in ipsilateral nodal axillary and/or sternal region, else as PET-negative. The differences of 15 years restricted mean survival time
∆
RMST
according to PET and LNR were computed from Kaplan–Meier overall survival. The effect of PET and other patients' characteristics was analyzed through rankit normalization, which provides with Cox regression the Royston–Sauerbrei
D
measure of separation to compare the characteristics (0 indicating no prognostic value). Multivariate analysis of the normalized characteristics used stepwise selection with the Akaike information criterion.
Results
In Kaplan–Meier analysis, LNR > 0.20 versus ≤ 0.20 showed
∆
RMST
= 3.4 years,
P
= 0.003. PET-Axillary|Sternal positivity versus PET-negative showed a
∆
RMST
= 2.6 years,
P
= 0.008. In Cox univariate analyses, LNR appeared as topmost prognostic separator,
D
= 1.50,
P
< 0.001. PET ranked below but was also highly significant,
D
= 1.02,
P
= 0.009. In multivariate analyses, LNR and PET-Axillary|Sternal were colinear and mutually exclusive. PET-Axillary|Sternal improved as prognosticator in a model excluding lymph nodes, yielding a normalized hazard ratio of 2.44,
P
= 0.062.
Conclusion
Pathological lymph node assessment remains the gold standard of prognosis. However, PET appears as a valuable surrogate in univariate analysis at 15-year follow-up. There was a trend towards significance in multivariate analysis that warrants further investigation.</description><subject>Cancer Research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1340-6868</issn><issn>1880-4233</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhisEEmPwBzjlyIGAk3RNeuRjG0iT4DDOUZZ6W6e2KUk3tP16spUzJ1vW81r2kyS3DB4YgHwMjHPFKXBGgXGR0sNZMmBKAU25EOexFynQTGXqMrkKYQOQCgnZIHHPHk3oiDWNRU9aj65Fb7pyh4SpyeuUfo7n98Tt4rCqSNj6XbkzVQTdqnGhKy0J2JpjwjXEujr2WJCfsluTbo2k2tftmjSuQHJirpOLpakC3vzVYfI1Gc9f3ujsY_r-8jSjVnDe0UJlolhIhSMlWS6VLbhJJTejAkBIzjKWKSYtW3CWAkqVIV8YvpQjUAaKPBPD5K7fGw_93mLodF0Gi1VlGnTboHma57mAEeQR5T1qvQvB41K3vqyN32sG-mhX93Z1tKtPdvUhhkQfChFuVuj1xm19E1_6L_ULE6h90Q</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Vinh-Hung, Vincent</creator><creator>Everaert, Hendrik</creator><creator>Gorobets, Olena</creator><creator>Van Parijs, Hilde</creator><creator>Verfaillie, Guy</creator><creator>Vanhoeij, Marian</creator><creator>Storme, Guy</creator><creator>Fontaine, Christel</creator><creator>Lamote, Jan</creator><creator>Perrin, Justine</creator><creator>Farid, Karim</creator><creator>Nguyen, Nam P.</creator><creator>Verschraegen, Claire</creator><creator>De Ridder, Mark</creator><general>Springer Singapore</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6403-6120</orcidid></search><sort><creationdate>20210701</creationdate><title>Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio</title><author>Vinh-Hung, Vincent ; Everaert, Hendrik ; Gorobets, Olena ; Van Parijs, Hilde ; Verfaillie, Guy ; Vanhoeij, Marian ; Storme, Guy ; Fontaine, Christel ; Lamote, Jan ; Perrin, Justine ; Farid, Karim ; Nguyen, Nam P. ; Verschraegen, Claire ; De Ridder, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-d863db78e5871978cd2a472a5d003721616817c1b2140e786e2ba2f7508a0d963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer Research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vinh-Hung, Vincent</creatorcontrib><creatorcontrib>Everaert, Hendrik</creatorcontrib><creatorcontrib>Gorobets, Olena</creatorcontrib><creatorcontrib>Van Parijs, Hilde</creatorcontrib><creatorcontrib>Verfaillie, Guy</creatorcontrib><creatorcontrib>Vanhoeij, Marian</creatorcontrib><creatorcontrib>Storme, Guy</creatorcontrib><creatorcontrib>Fontaine, Christel</creatorcontrib><creatorcontrib>Lamote, Jan</creatorcontrib><creatorcontrib>Perrin, Justine</creatorcontrib><creatorcontrib>Farid, Karim</creatorcontrib><creatorcontrib>Nguyen, Nam P.</creatorcontrib><creatorcontrib>Verschraegen, Claire</creatorcontrib><creatorcontrib>De Ridder, Mark</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vinh-Hung, Vincent</au><au>Everaert, Hendrik</au><au>Gorobets, Olena</au><au>Van Parijs, Hilde</au><au>Verfaillie, Guy</au><au>Vanhoeij, Marian</au><au>Storme, Guy</au><au>Fontaine, Christel</au><au>Lamote, Jan</au><au>Perrin, Justine</au><au>Farid, Karim</au><au>Nguyen, Nam P.</au><au>Verschraegen, Claire</au><au>De Ridder, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><stitle>Breast Cancer</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>28</volume><issue>4</issue><spage>956</spage><epage>968</epage><pages>956-968</pages><issn>1340-6868</issn><issn>1880-4233</issn><eissn>1880-4233</eissn><abstract>Purpose
To evaluate the overall survival prognostic value of preoperative
18
F-fluorodeoxyglucose positron emission tomography (PET) in breast cancer, as compared with the lymph node ratio (LNR).
Methods
Data were abstracted at a median follow-up 14.7 years from a retrospective cohort of 104 patients who underwent PET imaging before curative surgery. PET-Axillary|Sternal was classified as PET-positive if hypermetabolism was visualized in ipsilateral nodal axillary and/or sternal region, else as PET-negative. The differences of 15 years restricted mean survival time
∆
RMST
according to PET and LNR were computed from Kaplan–Meier overall survival. The effect of PET and other patients' characteristics was analyzed through rankit normalization, which provides with Cox regression the Royston–Sauerbrei
D
measure of separation to compare the characteristics (0 indicating no prognostic value). Multivariate analysis of the normalized characteristics used stepwise selection with the Akaike information criterion.
Results
In Kaplan–Meier analysis, LNR > 0.20 versus ≤ 0.20 showed
∆
RMST
= 3.4 years,
P
= 0.003. PET-Axillary|Sternal positivity versus PET-negative showed a
∆
RMST
= 2.6 years,
P
= 0.008. In Cox univariate analyses, LNR appeared as topmost prognostic separator,
D
= 1.50,
P
< 0.001. PET ranked below but was also highly significant,
D
= 1.02,
P
= 0.009. In multivariate analyses, LNR and PET-Axillary|Sternal were colinear and mutually exclusive. PET-Axillary|Sternal improved as prognosticator in a model excluding lymph nodes, yielding a normalized hazard ratio of 2.44,
P
= 0.062.
Conclusion
Pathological lymph node assessment remains the gold standard of prognosis. However, PET appears as a valuable surrogate in univariate analysis at 15-year follow-up. There was a trend towards significance in multivariate analysis that warrants further investigation.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><doi>10.1007/s12282-021-01234-z</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6403-6120</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-6868 |
| ispartof | Breast cancer (Tokyo, Japan), 2021-07, Vol.28 (4), p.956-968 |
| issn | 1340-6868 1880-4233 1880-4233 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2499930509 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Research Medicine Medicine & Public Health Oncology Original Article Surgery Surgical Oncology |
| title | Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T21%3A17%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Breast%20cancer%20preoperative%2018FDG-PET,%20overall%20survival%20prognostic%20separation%20compared%20with%20the%20lymph%20node%20ratio&rft.jtitle=Breast%20cancer%20(Tokyo,%20Japan)&rft.au=Vinh-Hung,%20Vincent&rft.date=2021-07-01&rft.volume=28&rft.issue=4&rft.spage=956&rft.epage=968&rft.pages=956-968&rft.issn=1340-6868&rft.eissn=1880-4233&rft_id=info:doi/10.1007/s12282-021-01234-z&rft_dat=%3Cproquest_cross%3E2499930509%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2499930509&rft_id=info:pmid/&rfr_iscdi=true |