CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity

CDK1 plays key roles in cell cycle progression through the G2/M phase transition and activation of homologous recombination (HR) DNA repair pathway. Accordingly, various CDK1 inhibitors have been developed for cancer therapy that induce prolonged G2 arrest and/or sensitize cells to DNA damaging agen...

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Veröffentlicht in:	Biochemical and biophysical research communications 2021-04, Vol.550, p.56-61
Hauptverfasser:	Sunada, Shigeaki, Saito, Hiroko, Zhang, Doudou, Xu, Zeyu, Miki, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	CDK inhibitor DNA damage Response DSB repair G2 arrest Homologous recombination
Online-Zugang:	Volltext
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