Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study
Background There are no published data on Mild Cognitive Impairment (MCI) incidence in people over 65 years of age in Greece, relevant literature is scarce for Southern Europe, and reported rates worldwide show great variability. Aims To investigate the incidence and risk factors of MCI and its subt...
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| Veröffentlicht in: | Aging clinical and experimental research 2021-10, Vol.33 (10), p.2679-2688 |
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| creator | Vlachos, George S. Kosmidis, Mary H. Yannakoulia, Mary Dardiotis, Efthimios Hadjigeorgiou, Georgios Tzoulaki, Ioanna Georgiou, Andrea N. Sakka, Paraskevi Anastasiou, Costas A. Stefanis, Leonidas Scarmeas, Nikolaos |
| description | Background
There are no published data on Mild Cognitive Impairment (MCI) incidence in people over 65 years of age in Greece, relevant literature is scarce for Southern Europe, and reported rates worldwide show great variability.
Aims
To investigate the incidence and risk factors of MCI and its subtypes in the elderly population in Greece.
Methods
The incidence cohort of the HELIAD study (Hellenic Epidemiological Longitudinal Investigation of Aging and Diet) comprised 955 individuals who received full neurological and neuropsychological evaluation on two separate occasions about three years apart.
Results
The MCI incidence rate in our cohort is 54.07 new cases per 1000 person-years, standardized by age and sex to 59.99. Each additional year of age over 65 raises the probability of novel MCI by 6.2%, while lower educational attainment more than doubles the risk for incident MCI.
Apolipoprotein E-ε4 (APOE-ε4)
carriage results in increased risk for MCI by more than 1.7 times. Incidence rates for amnestic MCI are slightly higher than for the non-amnestic subtype, and AD is the most common potential underlying etiology.
Discussion
The MCI incidence rate in the Greek population over 65 years of age is 54/1000 person-years. Advanced age and
APOE-ε4
carriage are predisposing factors, while higher educational attainment was found to exert a protective effect.
Conclusions
MCI incidence in people over 65 years-old in Greece is consistent with reported rates around the world. Larger studies encompassing neuroimaging and cerebrospinal fluid biomarkers will hopefully shed more light on MCI epidemiology in Greece in the future. |
| doi_str_mv | 10.1007/s40520-021-01819-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2499388979</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2584135443</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a9ad110ee23c86ff492423980a6cae355a7f9cd157835996723abee4599efe303</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq2Kqmxp_0APyBIXLqH-TOzeVls-VlqJCz1bxplQo8RO7YTV_vsalhbEgdPMeJ55x5oXoW-UnFFCmu9ZEMlIRRitCFVUV9sPaEGb8qQ41Qev8kP0Oed7QgQtxSd0yHmtain4Avl1cL6F4ADHDg--b7GLd8FP_gGwH0br0wBhwj7g6Tdg6FtI_Q6PcZx7O_kYHjuXCcDBD5wgz_2UcZfi8IRfnW_Wy584T3O7-4I-drbP8PU5HqFfF-c3q6tqc325Xi03leONnCqrbUspAWDcqbrrhGaCca2IrZ0FLqVtOu1aKhvFpdZ1w7i9BRAlhw444UfodK87pvhnhjyZwWcHfW8DxDkbJrTmSulGF_TkDXof5xTK7wyTqhxLCsELxfaUSzHnBJ0Zkx9s2hlKzKMRZm-EKUaYJyPMtgwdP0vPtwO0_0f-Xb4AfA_k0gp3kF52vyP7FyIrk3M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2584135443</pqid></control><display><type>article</type><title>Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study</title><source>SpringerLink Journals</source><creator>Vlachos, George S. ; Kosmidis, Mary H. ; Yannakoulia, Mary ; Dardiotis, Efthimios ; Hadjigeorgiou, Georgios ; Tzoulaki, Ioanna ; Georgiou, Andrea N. ; Sakka, Paraskevi ; Anastasiou, Costas A. ; Stefanis, Leonidas ; Scarmeas, Nikolaos</creator><creatorcontrib>Vlachos, George S. ; Kosmidis, Mary H. ; Yannakoulia, Mary ; Dardiotis, Efthimios ; Hadjigeorgiou, Georgios ; Tzoulaki, Ioanna ; Georgiou, Andrea N. ; Sakka, Paraskevi ; Anastasiou, Costas A. ; Stefanis, Leonidas ; Scarmeas, Nikolaos</creatorcontrib><description>Background
There are no published data on Mild Cognitive Impairment (MCI) incidence in people over 65 years of age in Greece, relevant literature is scarce for Southern Europe, and reported rates worldwide show great variability.
Aims
To investigate the incidence and risk factors of MCI and its subtypes in the elderly population in Greece.
Methods
The incidence cohort of the HELIAD study (Hellenic Epidemiological Longitudinal Investigation of Aging and Diet) comprised 955 individuals who received full neurological and neuropsychological evaluation on two separate occasions about three years apart.
Results
The MCI incidence rate in our cohort is 54.07 new cases per 1000 person-years, standardized by age and sex to 59.99. Each additional year of age over 65 raises the probability of novel MCI by 6.2%, while lower educational attainment more than doubles the risk for incident MCI.
Apolipoprotein E-ε4 (APOE-ε4)
carriage results in increased risk for MCI by more than 1.7 times. Incidence rates for amnestic MCI are slightly higher than for the non-amnestic subtype, and AD is the most common potential underlying etiology.
Discussion
The MCI incidence rate in the Greek population over 65 years of age is 54/1000 person-years. Advanced age and
APOE-ε4
carriage are predisposing factors, while higher educational attainment was found to exert a protective effect.
Conclusions
MCI incidence in people over 65 years-old in Greece is consistent with reported rates around the world. Larger studies encompassing neuroimaging and cerebrospinal fluid biomarkers will hopefully shed more light on MCI epidemiology in Greece in the future.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-021-01819-w</identifier><identifier>PMID: 33686543</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age ; Cognitive ability ; Educational attainment ; Epidemiology ; Geriatrics/Gerontology ; Medicine ; Medicine & Public Health ; Older people ; Original Article</subject><ispartof>Aging clinical and experimental research, 2021-10, Vol.33 (10), p.2679-2688</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a9ad110ee23c86ff492423980a6cae355a7f9cd157835996723abee4599efe303</citedby><cites>FETCH-LOGICAL-c375t-a9ad110ee23c86ff492423980a6cae355a7f9cd157835996723abee4599efe303</cites><orcidid>0000-0002-0757-2808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-021-01819-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-021-01819-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33686543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vlachos, George S.</creatorcontrib><creatorcontrib>Kosmidis, Mary H.</creatorcontrib><creatorcontrib>Yannakoulia, Mary</creatorcontrib><creatorcontrib>Dardiotis, Efthimios</creatorcontrib><creatorcontrib>Hadjigeorgiou, Georgios</creatorcontrib><creatorcontrib>Tzoulaki, Ioanna</creatorcontrib><creatorcontrib>Georgiou, Andrea N.</creatorcontrib><creatorcontrib>Sakka, Paraskevi</creatorcontrib><creatorcontrib>Anastasiou, Costas A.</creatorcontrib><creatorcontrib>Stefanis, Leonidas</creatorcontrib><creatorcontrib>Scarmeas, Nikolaos</creatorcontrib><title>Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
There are no published data on Mild Cognitive Impairment (MCI) incidence in people over 65 years of age in Greece, relevant literature is scarce for Southern Europe, and reported rates worldwide show great variability.
Aims
To investigate the incidence and risk factors of MCI and its subtypes in the elderly population in Greece.
Methods
The incidence cohort of the HELIAD study (Hellenic Epidemiological Longitudinal Investigation of Aging and Diet) comprised 955 individuals who received full neurological and neuropsychological evaluation on two separate occasions about three years apart.
Results
The MCI incidence rate in our cohort is 54.07 new cases per 1000 person-years, standardized by age and sex to 59.99. Each additional year of age over 65 raises the probability of novel MCI by 6.2%, while lower educational attainment more than doubles the risk for incident MCI.
Apolipoprotein E-ε4 (APOE-ε4)
carriage results in increased risk for MCI by more than 1.7 times. Incidence rates for amnestic MCI are slightly higher than for the non-amnestic subtype, and AD is the most common potential underlying etiology.
Discussion
The MCI incidence rate in the Greek population over 65 years of age is 54/1000 person-years. Advanced age and
APOE-ε4
carriage are predisposing factors, while higher educational attainment was found to exert a protective effect.
Conclusions
MCI incidence in people over 65 years-old in Greece is consistent with reported rates around the world. Larger studies encompassing neuroimaging and cerebrospinal fluid biomarkers will hopefully shed more light on MCI epidemiology in Greece in the future.</description><subject>Age</subject><subject>Cognitive ability</subject><subject>Educational attainment</subject><subject>Epidemiology</subject><subject>Geriatrics/Gerontology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Older people</subject><subject>Original Article</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kU1P3DAQhq2Kqmxp_0APyBIXLqH-TOzeVls-VlqJCz1bxplQo8RO7YTV_vsalhbEgdPMeJ55x5oXoW-UnFFCmu9ZEMlIRRitCFVUV9sPaEGb8qQ41Qev8kP0Oed7QgQtxSd0yHmtain4Avl1cL6F4ADHDg--b7GLd8FP_gGwH0br0wBhwj7g6Tdg6FtI_Q6PcZx7O_kYHjuXCcDBD5wgz_2UcZfi8IRfnW_Wy584T3O7-4I-drbP8PU5HqFfF-c3q6tqc325Xi03leONnCqrbUspAWDcqbrrhGaCca2IrZ0FLqVtOu1aKhvFpdZ1w7i9BRAlhw444UfodK87pvhnhjyZwWcHfW8DxDkbJrTmSulGF_TkDXof5xTK7wyTqhxLCsELxfaUSzHnBJ0Zkx9s2hlKzKMRZm-EKUaYJyPMtgwdP0vPtwO0_0f-Xb4AfA_k0gp3kF52vyP7FyIrk3M</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Vlachos, George S.</creator><creator>Kosmidis, Mary H.</creator><creator>Yannakoulia, Mary</creator><creator>Dardiotis, Efthimios</creator><creator>Hadjigeorgiou, Georgios</creator><creator>Tzoulaki, Ioanna</creator><creator>Georgiou, Andrea N.</creator><creator>Sakka, Paraskevi</creator><creator>Anastasiou, Costas A.</creator><creator>Stefanis, Leonidas</creator><creator>Scarmeas, Nikolaos</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0757-2808</orcidid></search><sort><creationdate>20211001</creationdate><title>Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study</title><author>Vlachos, George S. ; Kosmidis, Mary H. ; Yannakoulia, Mary ; Dardiotis, Efthimios ; Hadjigeorgiou, Georgios ; Tzoulaki, Ioanna ; Georgiou, Andrea N. ; Sakka, Paraskevi ; Anastasiou, Costas A. ; Stefanis, Leonidas ; Scarmeas, Nikolaos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a9ad110ee23c86ff492423980a6cae355a7f9cd157835996723abee4599efe303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Cognitive ability</topic><topic>Educational attainment</topic><topic>Epidemiology</topic><topic>Geriatrics/Gerontology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Older people</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vlachos, George S.</creatorcontrib><creatorcontrib>Kosmidis, Mary H.</creatorcontrib><creatorcontrib>Yannakoulia, Mary</creatorcontrib><creatorcontrib>Dardiotis, Efthimios</creatorcontrib><creatorcontrib>Hadjigeorgiou, Georgios</creatorcontrib><creatorcontrib>Tzoulaki, Ioanna</creatorcontrib><creatorcontrib>Georgiou, Andrea N.</creatorcontrib><creatorcontrib>Sakka, Paraskevi</creatorcontrib><creatorcontrib>Anastasiou, Costas A.</creatorcontrib><creatorcontrib>Stefanis, Leonidas</creatorcontrib><creatorcontrib>Scarmeas, Nikolaos</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vlachos, George S.</au><au>Kosmidis, Mary H.</au><au>Yannakoulia, Mary</au><au>Dardiotis, Efthimios</au><au>Hadjigeorgiou, Georgios</au><au>Tzoulaki, Ioanna</au><au>Georgiou, Andrea N.</au><au>Sakka, Paraskevi</au><au>Anastasiou, Costas A.</au><au>Stefanis, Leonidas</au><au>Scarmeas, Nikolaos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>33</volume><issue>10</issue><spage>2679</spage><epage>2688</epage><pages>2679-2688</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
There are no published data on Mild Cognitive Impairment (MCI) incidence in people over 65 years of age in Greece, relevant literature is scarce for Southern Europe, and reported rates worldwide show great variability.
Aims
To investigate the incidence and risk factors of MCI and its subtypes in the elderly population in Greece.
Methods
The incidence cohort of the HELIAD study (Hellenic Epidemiological Longitudinal Investigation of Aging and Diet) comprised 955 individuals who received full neurological and neuropsychological evaluation on two separate occasions about three years apart.
Results
The MCI incidence rate in our cohort is 54.07 new cases per 1000 person-years, standardized by age and sex to 59.99. Each additional year of age over 65 raises the probability of novel MCI by 6.2%, while lower educational attainment more than doubles the risk for incident MCI.
Apolipoprotein E-ε4 (APOE-ε4)
carriage results in increased risk for MCI by more than 1.7 times. Incidence rates for amnestic MCI are slightly higher than for the non-amnestic subtype, and AD is the most common potential underlying etiology.
Discussion
The MCI incidence rate in the Greek population over 65 years of age is 54/1000 person-years. Advanced age and
APOE-ε4
carriage are predisposing factors, while higher educational attainment was found to exert a protective effect.
Conclusions
MCI incidence in people over 65 years-old in Greece is consistent with reported rates around the world. Larger studies encompassing neuroimaging and cerebrospinal fluid biomarkers will hopefully shed more light on MCI epidemiology in Greece in the future.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33686543</pmid><doi>10.1007/s40520-021-01819-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0757-2808</orcidid></addata></record> |
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| source | SpringerLink Journals |
| subjects | Age Cognitive ability Educational attainment Epidemiology Geriatrics/Gerontology Medicine Medicine & Public Health Older people Original Article |
| title | Incidence of mild cognitive impairment in the elderly population in Greece: results from the HELIAD study |
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