Therapy of antigen-induced arthritis of the temporomandibular joint via platelet-rich plasma injections in domestic pigs
The aim of this animal study was to investigate the effect of platelet-rich plasma (PRP) injections into the temporomandibular joint (TMJ) to treat antigen-induced arthritis AIA. AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein anal...
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| Veröffentlicht in: | Journal of cranio-maxillo-facial surgery 2021-08, Vol.49 (8), p.726-731 |
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| container_title | Journal of cranio-maxillo-facial surgery |
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| creator | Naujokat, Hendrik Sengebusch, André Loger, Klaas Möller, Björn Açil, Yahya Wiltfang, Jörg |
| description | The aim of this animal study was to investigate the effect of platelet-rich plasma (PRP) injections into the temporomandibular joint (TMJ) to treat antigen-induced arthritis AIA.
AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein analysis results indicating inflammation of the TMJ were observed. Afterwards, two PRP injections were performed over an interval of 2 weeks.
Concentration levels of the proinflammatory cytokines IL-1β (PRP: 33.7 ± 5.6 pg/mg, untreated: 50.0 ± 2.9 pg/mg; p = 0.04) and TNF-α (PRP: 20.7 ± 2.5 pg/mg, untreated: 31.4 ± 2.7 pg/mg; p = 0.03) were significantly decreased in the PRP-treated joints. A significant reduction in signs of histological inflammation, such as hyperplasia of the synovial membrane, leucocyte infiltration, cartilage surface alterations, and an increase in cartilage-specific glycosaminoglycan content, was observed.
This animal study supports the understanding of the underlying effects of PRP treatment in the TMJ, and may enhance novel PRP therapies in the future. |
| doi_str_mv | 10.1016/j.jcms.2021.02.022 |
| format | Article |
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AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein analysis results indicating inflammation of the TMJ were observed. Afterwards, two PRP injections were performed over an interval of 2 weeks.
Concentration levels of the proinflammatory cytokines IL-1β (PRP: 33.7 ± 5.6 pg/mg, untreated: 50.0 ± 2.9 pg/mg; p = 0.04) and TNF-α (PRP: 20.7 ± 2.5 pg/mg, untreated: 31.4 ± 2.7 pg/mg; p = 0.03) were significantly decreased in the PRP-treated joints. A significant reduction in signs of histological inflammation, such as hyperplasia of the synovial membrane, leucocyte infiltration, cartilage surface alterations, and an increase in cartilage-specific glycosaminoglycan content, was observed.
This animal study supports the understanding of the underlying effects of PRP treatment in the TMJ, and may enhance novel PRP therapies in the future.</description><identifier>ISSN: 1010-5182</identifier><identifier>EISSN: 1878-4119</identifier><identifier>DOI: 10.1016/j.jcms.2021.02.022</identifier><identifier>PMID: 33676818</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Dentistry ; Large-animal model ; Platelet-rich plasma ; Rheumatoid arthritis ; Temporomandibular joint</subject><ispartof>Journal of cranio-maxillo-facial surgery, 2021-08, Vol.49 (8), p.726-731</ispartof><rights>2021 European Association for Cranio-Maxillo-Facial Surgery</rights><rights>Copyright © 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b35e212e787aad58ba401a310d8ae9118629bcfdaabfa50e60e6f99c0565747f3</citedby><cites>FETCH-LOGICAL-c356t-b35e212e787aad58ba401a310d8ae9118629bcfdaabfa50e60e6f99c0565747f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1010518221000792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33676818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naujokat, Hendrik</creatorcontrib><creatorcontrib>Sengebusch, André</creatorcontrib><creatorcontrib>Loger, Klaas</creatorcontrib><creatorcontrib>Möller, Björn</creatorcontrib><creatorcontrib>Açil, Yahya</creatorcontrib><creatorcontrib>Wiltfang, Jörg</creatorcontrib><title>Therapy of antigen-induced arthritis of the temporomandibular joint via platelet-rich plasma injections in domestic pigs</title><title>Journal of cranio-maxillo-facial surgery</title><addtitle>J Craniomaxillofac Surg</addtitle><description>The aim of this animal study was to investigate the effect of platelet-rich plasma (PRP) injections into the temporomandibular joint (TMJ) to treat antigen-induced arthritis AIA.
AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein analysis results indicating inflammation of the TMJ were observed. Afterwards, two PRP injections were performed over an interval of 2 weeks.
Concentration levels of the proinflammatory cytokines IL-1β (PRP: 33.7 ± 5.6 pg/mg, untreated: 50.0 ± 2.9 pg/mg; p = 0.04) and TNF-α (PRP: 20.7 ± 2.5 pg/mg, untreated: 31.4 ± 2.7 pg/mg; p = 0.03) were significantly decreased in the PRP-treated joints. A significant reduction in signs of histological inflammation, such as hyperplasia of the synovial membrane, leucocyte infiltration, cartilage surface alterations, and an increase in cartilage-specific glycosaminoglycan content, was observed.
This animal study supports the understanding of the underlying effects of PRP treatment in the TMJ, and may enhance novel PRP therapies in the future.</description><subject>Dentistry</subject><subject>Large-animal model</subject><subject>Platelet-rich plasma</subject><subject>Rheumatoid arthritis</subject><subject>Temporomandibular joint</subject><issn>1010-5182</issn><issn>1878-4119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM1q3TAQhUVpadK0L9BF0bIb30rytSxBNyH0DwLdpGsxlsa5MrbkSnJo3r4yN-mycGBGzJkz6CPkPWcHzrj8NB0mu-SDYIIfmKgSL8glV71qjpzrl7VnnDUdV-KCvMl5YoxJpvRrctG2speKq0vy5-6ECdZHGkcKofh7DI0PbrPoKKRySr74vA_LCWnBZY0pLhCcH7YZEp2iD4U-eKDrDAVnLE3y9rS_8gLUhwlt8THk2lIXF8zFW7r6-_yWvBphzvjuqV6RX1-_3N18b25_fvtxc33b2LaTpRnaDgUX2KsewHVqgCPj0HLmFKDmXEmhBzs6gGGEjqGsGrW2rJNdf-zH9op8POeuKf7e6n2z-GxxniFg3LIRR6207jWX1SrOVptizglHsya_QHo0nJmduJnMTtzsxA0TVaIufXjK34YF3b-VZ8TV8PlswPrLB4_JZOsxVMA-VTjGRf-__L-OLJTn</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Naujokat, Hendrik</creator><creator>Sengebusch, André</creator><creator>Loger, Klaas</creator><creator>Möller, Björn</creator><creator>Açil, Yahya</creator><creator>Wiltfang, Jörg</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210801</creationdate><title>Therapy of antigen-induced arthritis of the temporomandibular joint via platelet-rich plasma injections in domestic pigs</title><author>Naujokat, Hendrik ; Sengebusch, André ; Loger, Klaas ; Möller, Björn ; Açil, Yahya ; Wiltfang, Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b35e212e787aad58ba401a310d8ae9118629bcfdaabfa50e60e6f99c0565747f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Dentistry</topic><topic>Large-animal model</topic><topic>Platelet-rich plasma</topic><topic>Rheumatoid arthritis</topic><topic>Temporomandibular joint</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naujokat, Hendrik</creatorcontrib><creatorcontrib>Sengebusch, André</creatorcontrib><creatorcontrib>Loger, Klaas</creatorcontrib><creatorcontrib>Möller, Björn</creatorcontrib><creatorcontrib>Açil, Yahya</creatorcontrib><creatorcontrib>Wiltfang, Jörg</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cranio-maxillo-facial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naujokat, Hendrik</au><au>Sengebusch, André</au><au>Loger, Klaas</au><au>Möller, Björn</au><au>Açil, Yahya</au><au>Wiltfang, Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapy of antigen-induced arthritis of the temporomandibular joint via platelet-rich plasma injections in domestic pigs</atitle><jtitle>Journal of cranio-maxillo-facial surgery</jtitle><addtitle>J Craniomaxillofac Surg</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>49</volume><issue>8</issue><spage>726</spage><epage>731</epage><pages>726-731</pages><issn>1010-5182</issn><eissn>1878-4119</eissn><abstract>The aim of this animal study was to investigate the effect of platelet-rich plasma (PRP) injections into the temporomandibular joint (TMJ) to treat antigen-induced arthritis AIA.
AIA was induced via the application of bovine serum albumin (BSA) into the TMJ. Clear histological signs and protein analysis results indicating inflammation of the TMJ were observed. Afterwards, two PRP injections were performed over an interval of 2 weeks.
Concentration levels of the proinflammatory cytokines IL-1β (PRP: 33.7 ± 5.6 pg/mg, untreated: 50.0 ± 2.9 pg/mg; p = 0.04) and TNF-α (PRP: 20.7 ± 2.5 pg/mg, untreated: 31.4 ± 2.7 pg/mg; p = 0.03) were significantly decreased in the PRP-treated joints. A significant reduction in signs of histological inflammation, such as hyperplasia of the synovial membrane, leucocyte infiltration, cartilage surface alterations, and an increase in cartilage-specific glycosaminoglycan content, was observed.
This animal study supports the understanding of the underlying effects of PRP treatment in the TMJ, and may enhance novel PRP therapies in the future.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>33676818</pmid><doi>10.1016/j.jcms.2021.02.022</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Dentistry Large-animal model Platelet-rich plasma Rheumatoid arthritis Temporomandibular joint |
| title | Therapy of antigen-induced arthritis of the temporomandibular joint via platelet-rich plasma injections in domestic pigs |
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