Osteoinductive function of fucoidan on periodontal ligament stem cells: Role of PI3K/Akt and Wnt/β‐catenin signaling pathways

Background/Objectives Fucoidan has been focused as a multifunctional therapeutic uses including bone health supplements. However, the critical molecular mechanisms of fucoidan for bone therapeutic agents have not been fully understood. We investigated the osteoinductive effect of fucoidan on periodo...

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Veröffentlicht in:	Oral diseases 2022-09, Vol.28 (6), p.1628-1639
Hauptverfasser:	Shim, Na Young, Ryu, Jae‐In, Heo, Jung Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alkaline phosphatase Calcium (intracellular) Catenin Cell differentiation Fucoidan Gene expression Isoforms Kinases Ligaments Mineralization Molecular modelling Osteogenesis osteogenic differentiation Periodontal ligament periodontal ligament stem cells Phosphorylation PI3K/Akt siRNA Stem cells Wnt protein Wnt/β‐catenin
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