Development and validation of a liquid chromatography method using UV/fluorescence detection for the quantitative determination of metabolites of the kynurenine pathway in human urine: Application to patients with heart failure

[Display omitted] •A LC-UV/FD method for the quantification of kinurenine pathway metabolites in urine.•The method was applied to healthy volunteers and heart failure (HF) patients.•Tryptophan metabolites analysis corroborates the inflammatory status of HF patients.•Distinct tryptophan metabolites p...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2021-05, Vol.198, p.113997-113997, Article 113997
Hauptverfasser:	Sousa, Ana, Ribeiro, Cláudia, Gonçalves, Virgínia M.F., Barbosa, Joana, Peixoto, Bruno, Andrade, Aurora, Silva, Patrícia, Andrade, José Paulo, Leal, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Heart disease Inflammatory biomarkers Kynurenic acid Kynurenine Liquid chromatography Tryptophan
Online-Zugang:	Volltext
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