Hypothalamic–pituitary organoid generation through the recapitulation of organogenesis

This paper overviews the development and differentiation of the hypothalamus and pituitary gland from embryonic stem (ES) and induced pluripotent stem (iPS) cells. It is important to replicate the developmental process in vivo to create specific cells/organoids from ES/iPS cells. We also introduce t...

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Veröffentlicht in:	Development, growth & differentiation growth & differentiation, 2021-02, Vol.63 (2), p.154-165
Hauptverfasser:	Ozaki, Hajime, Suga, Hidetaka, Arima, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell differentiation Developmental disabilities Ectoderm Embryogenesis ES/iPS cells Hypopituitarism Hypothalamus Neuroectoderm Organogenesis Organoids Pattern formation Pituitary Pituitary (anterior) Pluripotency self‐organization Stem cells three‐dimensional culture Transplantation Vasopressin
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