Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis
Objective To investigate the impact of penile rehabilitation on the recovery of erectile function after robot‐assisted radical prostatectomy. Methods Patients who underwent robot‐assisted radical prostatectomy in our department from 2010 to 2019 were included. For penile rehabilitation, a phosphodie...
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| Veröffentlicht in: | International journal of urology 2021-06, Vol.28 (6), p.637-642 |
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| container_title | International journal of urology |
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| creator | Kimura, Yusuke Honda, Masashi Teraoka, Shogo Yumioka, Tetsuya Iwamoto, Hideto Morizane, Shuichi Hikita, Katsuya Takenaka, Atsushi |
| description | Objective
To investigate the impact of penile rehabilitation on the recovery of erectile function after robot‐assisted radical prostatectomy.
Methods
Patients who underwent robot‐assisted radical prostatectomy in our department from 2010 to 2019 were included. For penile rehabilitation, a phosphodiesterase‐5 inhibitor (tadalafil 20 mg) was administered twice a week for 1–6 months postoperatively. The International Index of Erectile Function questionnaire (question 1 and erectile function domain) and the Expanded Prostate Cancer Index Composite questionnaire (sexual function) were used.
Results
After propensity score matching, there were 79 patients in the penile rehabilitation group and 79 patients in the non‐penile rehabilitation group. There was no significant difference in baseline characteristics between the two groups. Significantly higher scores were seen in the penile rehabilitation group compared with the non‐penile rehabilitation group at postoperative 3, 6 and 9 months in the International Index of Erectile Function questionnaire‐question 1, at 3, 6, 9 and 12 months in erectile function domain, and at 3, 6, 12 and 24 months in Expanded Prostate Cancer Index Composite questionnaire sexual function (P |
| doi_str_mv | 10.1111/iju.14527 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2498506927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2536052899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3777-d79984ff415d004ef3aa05b8a73b043d362ab2ad88040226c592be8b857e38343</originalsourceid><addsrcrecordid>eNp1kUtu1TAYRi0EopfCgA0gS0xgkNbPxGFWVTwuqsSEjiPHcRpfJXawnVaZsQT2xS5YCX96CwMkLFmWreOjz_4QeknJGYVx7g7LGRWSVY_QjgrBCkYEe4x2pKZ1oWjFTtCzlA6EUM6oeopOOC9LTqjcoZ_7adYm49Dj2Xo3WhztoFs3uqyzCx7fuTzgeQgJZudsyjbqZH99_yGx84NrXQ4xYQCjNeHWxnVTWdjkTdYv3txrnMczCK3PCS--s_EmOH-DY2hDBplOyYG6w1F3zugRzzEkSACaMK3v8MV2AAGTyytOJsQtwaSzGeCO9npc4f5z9KTXY7IvHtZTdP3h_dfLT8XVl4_7y4urwvCqqoquqmsl-l5Q2REibM-1JrJVuuItEbzjJdMt051SRBDGSiNr1lrVKllZrrjgp-jN0QuZvi3wJc3kkrHjqL0NS2qYqJUkZc0qQF__gx7CEiEvUJKXRDJV10C9PVIGXp2i7Zs5uknHtaGk2RpuoOHmvmFgXz0Yl3ay3V_yT6UAnB-BOyhg_b-p2X--Pip_A9YtuFE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2536052899</pqid></control><display><type>article</type><title>Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Kimura, Yusuke ; Honda, Masashi ; Teraoka, Shogo ; Yumioka, Tetsuya ; Iwamoto, Hideto ; Morizane, Shuichi ; Hikita, Katsuya ; Takenaka, Atsushi</creator><creatorcontrib>Kimura, Yusuke ; Honda, Masashi ; Teraoka, Shogo ; Yumioka, Tetsuya ; Iwamoto, Hideto ; Morizane, Shuichi ; Hikita, Katsuya ; Takenaka, Atsushi</creatorcontrib><description>Objective
To investigate the impact of penile rehabilitation on the recovery of erectile function after robot‐assisted radical prostatectomy.
Methods
Patients who underwent robot‐assisted radical prostatectomy in our department from 2010 to 2019 were included. For penile rehabilitation, a phosphodiesterase‐5 inhibitor (tadalafil 20 mg) was administered twice a week for 1–6 months postoperatively. The International Index of Erectile Function questionnaire (question 1 and erectile function domain) and the Expanded Prostate Cancer Index Composite questionnaire (sexual function) were used.
Results
After propensity score matching, there were 79 patients in the penile rehabilitation group and 79 patients in the non‐penile rehabilitation group. There was no significant difference in baseline characteristics between the two groups. Significantly higher scores were seen in the penile rehabilitation group compared with the non‐penile rehabilitation group at postoperative 3, 6 and 9 months in the International Index of Erectile Function questionnaire‐question 1, at 3, 6, 9 and 12 months in erectile function domain, and at 3, 6, 12 and 24 months in Expanded Prostate Cancer Index Composite questionnaire sexual function (P < 0.05). There were significant improvements in the erectile recovery rate in the penile rehabilitation group compared with the non‐penile rehabilitation group in the nerve sparing (P = 0.006) and partial nerve sparing (P = 0.037) groups.
Conclusions
The present findings suggest that robot‐assisted radical prostatectomy patients who undergo not only nerve sparing, but also those who undergo patial nerve sparing could benefit from penile rehabilitation using a phosphodiesterase‐5 inhibitor.</description><identifier>ISSN: 0919-8172</identifier><identifier>ISSN: 1442-2042</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.14527</identifier><identifier>PMID: 33663015</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Cyclic Nucleotide Phosphodiesterases, Type 5 ; Erectile Dysfunction - drug therapy ; Erectile Dysfunction - etiology ; Erectile Dysfunction - surgery ; Humans ; Male ; nerve sparing ; Penile Erection ; penile rehabilitation ; Penis ; Phosphodiesterase ; Phosphodiesterase 5 Inhibitors - therapeutic use ; Propensity Score ; Prostate cancer ; Prostatectomy ; Prostatectomy - adverse effects ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - surgery ; Questionnaires ; Recovery of Function ; Rehabilitation ; Robotics ; Robots ; robot‐assisted radical prostatectomy ; sexual function</subject><ispartof>International journal of urology, 2021-06, Vol.28 (6), p.637-642</ispartof><rights>2021 The Japanese Urological Association</rights><rights>2021 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3777-d79984ff415d004ef3aa05b8a73b043d362ab2ad88040226c592be8b857e38343</citedby><cites>FETCH-LOGICAL-c3777-d79984ff415d004ef3aa05b8a73b043d362ab2ad88040226c592be8b857e38343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.14527$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.14527$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33663015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Yusuke</creatorcontrib><creatorcontrib>Honda, Masashi</creatorcontrib><creatorcontrib>Teraoka, Shogo</creatorcontrib><creatorcontrib>Yumioka, Tetsuya</creatorcontrib><creatorcontrib>Iwamoto, Hideto</creatorcontrib><creatorcontrib>Morizane, Shuichi</creatorcontrib><creatorcontrib>Hikita, Katsuya</creatorcontrib><creatorcontrib>Takenaka, Atsushi</creatorcontrib><title>Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objective
To investigate the impact of penile rehabilitation on the recovery of erectile function after robot‐assisted radical prostatectomy.
Methods
Patients who underwent robot‐assisted radical prostatectomy in our department from 2010 to 2019 were included. For penile rehabilitation, a phosphodiesterase‐5 inhibitor (tadalafil 20 mg) was administered twice a week for 1–6 months postoperatively. The International Index of Erectile Function questionnaire (question 1 and erectile function domain) and the Expanded Prostate Cancer Index Composite questionnaire (sexual function) were used.
Results
After propensity score matching, there were 79 patients in the penile rehabilitation group and 79 patients in the non‐penile rehabilitation group. There was no significant difference in baseline characteristics between the two groups. Significantly higher scores were seen in the penile rehabilitation group compared with the non‐penile rehabilitation group at postoperative 3, 6 and 9 months in the International Index of Erectile Function questionnaire‐question 1, at 3, 6, 9 and 12 months in erectile function domain, and at 3, 6, 12 and 24 months in Expanded Prostate Cancer Index Composite questionnaire sexual function (P < 0.05). There were significant improvements in the erectile recovery rate in the penile rehabilitation group compared with the non‐penile rehabilitation group in the nerve sparing (P = 0.006) and partial nerve sparing (P = 0.037) groups.
Conclusions
The present findings suggest that robot‐assisted radical prostatectomy patients who undergo not only nerve sparing, but also those who undergo patial nerve sparing could benefit from penile rehabilitation using a phosphodiesterase‐5 inhibitor.</description><subject>Cyclic Nucleotide Phosphodiesterases, Type 5</subject><subject>Erectile Dysfunction - drug therapy</subject><subject>Erectile Dysfunction - etiology</subject><subject>Erectile Dysfunction - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>nerve sparing</subject><subject>Penile Erection</subject><subject>penile rehabilitation</subject><subject>Penis</subject><subject>Phosphodiesterase</subject><subject>Phosphodiesterase 5 Inhibitors - therapeutic use</subject><subject>Propensity Score</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatectomy - adverse effects</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Questionnaires</subject><subject>Recovery of Function</subject><subject>Rehabilitation</subject><subject>Robotics</subject><subject>Robots</subject><subject>robot‐assisted radical prostatectomy</subject><subject>sexual function</subject><issn>0919-8172</issn><issn>1442-2042</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtu1TAYRi0EopfCgA0gS0xgkNbPxGFWVTwuqsSEjiPHcRpfJXawnVaZsQT2xS5YCX96CwMkLFmWreOjz_4QeknJGYVx7g7LGRWSVY_QjgrBCkYEe4x2pKZ1oWjFTtCzlA6EUM6oeopOOC9LTqjcoZ_7adYm49Dj2Xo3WhztoFs3uqyzCx7fuTzgeQgJZudsyjbqZH99_yGx84NrXQ4xYQCjNeHWxnVTWdjkTdYv3txrnMczCK3PCS--s_EmOH-DY2hDBplOyYG6w1F3zugRzzEkSACaMK3v8MV2AAGTyytOJsQtwaSzGeCO9npc4f5z9KTXY7IvHtZTdP3h_dfLT8XVl4_7y4urwvCqqoquqmsl-l5Q2REibM-1JrJVuuItEbzjJdMt051SRBDGSiNr1lrVKllZrrjgp-jN0QuZvi3wJc3kkrHjqL0NS2qYqJUkZc0qQF__gx7CEiEvUJKXRDJV10C9PVIGXp2i7Zs5uknHtaGk2RpuoOHmvmFgXz0Yl3ay3V_yT6UAnB-BOyhg_b-p2X--Pip_A9YtuFE</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Kimura, Yusuke</creator><creator>Honda, Masashi</creator><creator>Teraoka, Shogo</creator><creator>Yumioka, Tetsuya</creator><creator>Iwamoto, Hideto</creator><creator>Morizane, Shuichi</creator><creator>Hikita, Katsuya</creator><creator>Takenaka, Atsushi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>202106</creationdate><title>Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis</title><author>Kimura, Yusuke ; Honda, Masashi ; Teraoka, Shogo ; Yumioka, Tetsuya ; Iwamoto, Hideto ; Morizane, Shuichi ; Hikita, Katsuya ; Takenaka, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3777-d79984ff415d004ef3aa05b8a73b043d362ab2ad88040226c592be8b857e38343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cyclic Nucleotide Phosphodiesterases, Type 5</topic><topic>Erectile Dysfunction - drug therapy</topic><topic>Erectile Dysfunction - etiology</topic><topic>Erectile Dysfunction - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>nerve sparing</topic><topic>Penile Erection</topic><topic>penile rehabilitation</topic><topic>Penis</topic><topic>Phosphodiesterase</topic><topic>Phosphodiesterase 5 Inhibitors - therapeutic use</topic><topic>Propensity Score</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatectomy - adverse effects</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Questionnaires</topic><topic>Recovery of Function</topic><topic>Rehabilitation</topic><topic>Robotics</topic><topic>Robots</topic><topic>robot‐assisted radical prostatectomy</topic><topic>sexual function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Yusuke</creatorcontrib><creatorcontrib>Honda, Masashi</creatorcontrib><creatorcontrib>Teraoka, Shogo</creatorcontrib><creatorcontrib>Yumioka, Tetsuya</creatorcontrib><creatorcontrib>Iwamoto, Hideto</creatorcontrib><creatorcontrib>Morizane, Shuichi</creatorcontrib><creatorcontrib>Hikita, Katsuya</creatorcontrib><creatorcontrib>Takenaka, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Yusuke</au><au>Honda, Masashi</au><au>Teraoka, Shogo</au><au>Yumioka, Tetsuya</au><au>Iwamoto, Hideto</au><au>Morizane, Shuichi</au><au>Hikita, Katsuya</au><au>Takenaka, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2021-06</date><risdate>2021</risdate><volume>28</volume><issue>6</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0919-8172</issn><issn>1442-2042</issn><eissn>1442-2042</eissn><abstract>Objective
To investigate the impact of penile rehabilitation on the recovery of erectile function after robot‐assisted radical prostatectomy.
Methods
Patients who underwent robot‐assisted radical prostatectomy in our department from 2010 to 2019 were included. For penile rehabilitation, a phosphodiesterase‐5 inhibitor (tadalafil 20 mg) was administered twice a week for 1–6 months postoperatively. The International Index of Erectile Function questionnaire (question 1 and erectile function domain) and the Expanded Prostate Cancer Index Composite questionnaire (sexual function) were used.
Results
After propensity score matching, there were 79 patients in the penile rehabilitation group and 79 patients in the non‐penile rehabilitation group. There was no significant difference in baseline characteristics between the two groups. Significantly higher scores were seen in the penile rehabilitation group compared with the non‐penile rehabilitation group at postoperative 3, 6 and 9 months in the International Index of Erectile Function questionnaire‐question 1, at 3, 6, 9 and 12 months in erectile function domain, and at 3, 6, 12 and 24 months in Expanded Prostate Cancer Index Composite questionnaire sexual function (P < 0.05). There were significant improvements in the erectile recovery rate in the penile rehabilitation group compared with the non‐penile rehabilitation group in the nerve sparing (P = 0.006) and partial nerve sparing (P = 0.037) groups.
Conclusions
The present findings suggest that robot‐assisted radical prostatectomy patients who undergo not only nerve sparing, but also those who undergo patial nerve sparing could benefit from penile rehabilitation using a phosphodiesterase‐5 inhibitor.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33663015</pmid><doi>10.1111/iju.14527</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of urology, 2021-06, Vol.28 (6), p.637-642 |
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| subjects | Cyclic Nucleotide Phosphodiesterases, Type 5 Erectile Dysfunction - drug therapy Erectile Dysfunction - etiology Erectile Dysfunction - surgery Humans Male nerve sparing Penile Erection penile rehabilitation Penis Phosphodiesterase Phosphodiesterase 5 Inhibitors - therapeutic use Propensity Score Prostate cancer Prostatectomy Prostatectomy - adverse effects Prostatic Neoplasms - drug therapy Prostatic Neoplasms - surgery Questionnaires Recovery of Function Rehabilitation Robotics Robots robot‐assisted radical prostatectomy sexual function |
| title | Impact of penile rehabilitation with phosphodiesterase‐5 inhibitors on recovery of erectile function in patients undergoing robot‐assisted radical prostatectomy: A propensity score‐matched analysis |
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