Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors

[Display omitted] Inhibition of cdc2-like kinase1 (CLK1) could efficiently induce autophagy and it has been thought as a potential target for treatment of autophagy-related diseases. Herein we report the discovery of a series of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2021-06, Vol.41, p.127881-127881, Article 127881
Hauptverfasser:	Zhang, Yun, Xia, Anjie, Zhang, Shiyu, Lin, Guifeng, Liu, Jingming, Chen, Pei, Mu, Bo, Jiao, Yan, Xu, Wenwen, Chen, Mingxin, Li, Linli
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy CLK1 Small molecule inhibitor Structure-activity relationship
Online-Zugang:	Volltext
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