Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer

Esophageal cancer is a disease showing poor prognosis. Although combination chemotherapy using cisplatin (CDDP) and 5‐fluorouracil is standard for unresectable esophageal cancer, the response rate is 35%. Cancer stem cells (CSCs) and inflammation are reportedly responsible for the poor prognosis of...

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Veröffentlicht in:	International journal of cancer 2021-07, Vol.149 (2), p.347-357
Hauptverfasser:	Narusaka, Toru, Ohara, Toshiaki, Noma, Kazuhiro, Nishiwaki, Noriyuki, Katsura, Yuki, Kato, Takuya, Sato, Hiroaki, Tomono, Yasuko, Kikuchi, Satoru, Tazawa, Hiroshi, Shirakawa, Yasuhiro, Matsukawa, Akihiro, Fujiwara, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Cancer cancer stem cells Cell proliferation Chelating agents chelator Chemotherapy Cisplatin Drug delivery Drug development Esophageal cancer Esophagus Inflammation Iron Medical research Prognosis Stem cells stemness Therapeutic targets
Online-Zugang:	Volltext
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