Intranuclear strain in living cells subjected to substrate stretching: A combined experimental and computational study

Nuclear deformation caused by mechanical stimuli has been suggested to significantly impact various cellular activities, such as gene expression, protein synthesis and mechanotransduction. To understand how nuclear deformation regulates cellular behaviors, the details of intranuclear strain distribu...

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Veröffentlicht in:	Journal of biomechanics 2021-04, Vol.119, p.110292-110292, Article 110292
Hauptverfasser:	Tsukamoto, Shingo, Asakawa, Takumi, Kimura, Shun, Takesue, Naoyuki, Mofrad, Mohammad R.K., Sakamoto, Naoya
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cell cycle Cells (biology) Chromatin Computer applications Cytochalasin D Cytoskeleton Experiments Finite element method Fluorescence Gene expression Heterogeneity Intranuclear mechanical properties Intranuclear strain Mechanical properties Mechanical stimuli Mechanobiology Mechanotransduction Modulus of elasticity Nuclear biomechanics Nuclear deformation Nuclei (cytology) Protein biosynthesis Protein synthesis Shear strain Software Stimuli Strain distribution Stretching Substrates Trichostatin A
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