The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Non-enzymatic Methylation of Amino Acid Side Chains by SAM in Water

SAM is a powerful methylating agent, with a methyl group transfer potential matching the phosphoryl group transfer potential of ATP. SAM-dependent N-methyltransferases have evolved to catalyze the modification of specific lysine residues in histones and transcription factors, in addition to generati...

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Veröffentlicht in:	Biochemistry (Easton) 2021-03, Vol.60 (11), p.854-858
Hauptverfasser:	Lewis, Charles A, Wolfenden, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - metabolism Hydrogen-Ion Concentration Kinetics Methylation Protein Methyltransferases - chemistry Protein Methyltransferases - metabolism S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism Thermodynamics Water - chemistry Water - metabolism
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