Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study
Excessive adiposity in adulthood is positively associated with the risk of cardiovascular disease (CVD). However, it is less studied how the risk is separately explained by early adulthood weight and later weight change, especially in Asian ancestries. This study included 121160 participants in a la...
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| Veröffentlicht in: | International journal of cardiology 2021-06, Vol.332, p.209-215 |
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| creator | Zhu, Yuanyue Zheng, Ruizhi Hu, Chunyan Qin, Guijun Wang, Bin Wang, Tiange Yu, Xuefeng Tang, Xulei Hu, Ruying Su, Qing Zhang, Jie Zhang, Yi Zhao, Zhiyun Xu, Yu Li, Mian Chen, Yuhong Wang, Shuangyuan Shi, Lixin Wan, Qin Chen, Gang Dai, Meng Zhang, Di Gao, Zhengnan Wang, Guixia Shen, Feixia Luo, Zuojie Qin, Yingfen Chen, Li Huo, Yanan Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Chen, Lulu Zhao, Jiajun Mu, Yiming Yan, Li Wang, Weiqing Ning, Guang Bi, Yufang Lu, Jieli Xu, Min |
| description | Excessive adiposity in adulthood is positively associated with the risk of cardiovascular disease (CVD). However, it is less studied how the risk is separately explained by early adulthood weight and later weight change, especially in Asian ancestries.
This study included 121160 participants in a large population-based cohort in China. Body weight at 20 and 40 years of age wase self-reported. Information on CVD history was obtained through standard questionnaires.
The odds ratios (ORs) were 1.20 (95% CI, 1.10–1.31) for coronary heart disease (CHD), 1.74 (95% CI, 1.36–2.22) for myocardial infarction (MI), 1.14 (95% CI, 0.99–1.32) for stroke and 1.21 (95% CI, 1.12–1.31) for total CVD among individuals with early overweight, and became more prominent for early obesity. Meanwhile, A moderate weight gain of 2.5 kg between early adulthood and midlife significantly increased the risk of CHD (OR: 1.18, 95% CI: 1.05–1.32), stroke (OR: 1.19, 95% CI: 1.03–1.38) and total CVD (OR: 1.15, 95% CI: 1.04–1.27), and the risk escalated with higher amounts of weight gain. Conversely, a weight loss of 2.5 kg conferred lower risk of CVD compared with a stable weight. In further cross-analysis, participants with early adulthood overweight or obesity and significant weight gain afterwards exhibited the greatest risk of CVD.
High early adulthood BMI and subsequent weight gain had both independent and combined effect on the risk of CVD after midlife. Therefore, weight management should start before early adulthood, and emphasized throughout adulthood for CVD prevention.
•High early adulthood BMI and subsequent weight gain were independently and jointly associated with increased risk of CVD.•Attaining a weight loss of 2.5 kg or more might mitigate the CVD risk posed by excessive adiposity in early adulthood.•Weight management should start before early adulthood, and continue throughout adulthood in terms of CVD prevention. |
| doi_str_mv | 10.1016/j.ijcard.2021.02.086 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2498493139</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167527321003971</els_id><sourcerecordid>2498493139</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-c8b5ac7b5809e7dc27051b3ca94adf1e64ca47595f44d4e0c72b949de1d95d823</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpaLZp_0EpOvZiR5Jly-qhsCxJEwgNhPQsZGm8q8VrpRo5YQ_57_GySY49DQzPfLwPId84Kznjzfm2DFtnky8FE7xkomRt84EseKtkwVUtP5LFjKmiFqo6JZ8Rt4wxqXX7iZxWVdOoumUL8rxEjC7YHOJIY0_BpmFPrZ-GvInR0ycI602mdvQUpw7h3wRjfuu6jR3XQJ9C3tDDKyE-WnTTYBP1AcEi4E96GUYfxjXSPsUdvbtYru6vb_9QzJPffyEnvR0Qvr7WM_L38uJ-dVXc3P6-Xi1vClc1Iheu7WrrVDd_rEF5JxSreVc5q6X1PYdGOitVreteSi-BOSU6LbUH7nXtW1GdkR_HvQ8pzgkwm11AB8NgR4gTGiF1K3XFKz2j8oi6FBET9OYhhZ1Ne8OZOYg3W3MUbw7iDRNmFj-PfX-9MHU78O9Db6Zn4NcRgDnnY4Bk0AUYHfiQwGXjY_j_hRcQXZhc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2498493139</pqid></control><display><type>article</type><title>Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study</title><source>Access via ScienceDirect (Elsevier)</source><creator>Zhu, Yuanyue ; Zheng, Ruizhi ; Hu, Chunyan ; Qin, Guijun ; Wang, Bin ; Wang, Tiange ; Yu, Xuefeng ; Tang, Xulei ; Hu, Ruying ; Su, Qing ; Zhang, Jie ; Zhang, Yi ; Zhao, Zhiyun ; Xu, Yu ; Li, Mian ; Chen, Yuhong ; Wang, Shuangyuan ; Shi, Lixin ; Wan, Qin ; Chen, Gang ; Dai, Meng ; Zhang, Di ; Gao, Zhengnan ; Wang, Guixia ; Shen, Feixia ; Luo, Zuojie ; Qin, Yingfen ; Chen, Li ; Huo, Yanan ; Li, Qiang ; Ye, Zhen ; Zhang, Yinfei ; Liu, Chao ; Wang, Youmin ; Wu, Shengli ; Yang, Tao ; Deng, Huacong ; Chen, Lulu ; Zhao, Jiajun ; Mu, Yiming ; Yan, Li ; Wang, Weiqing ; Ning, Guang ; Bi, Yufang ; Lu, Jieli ; Xu, Min</creator><creatorcontrib>Zhu, Yuanyue ; Zheng, Ruizhi ; Hu, Chunyan ; Qin, Guijun ; Wang, Bin ; Wang, Tiange ; Yu, Xuefeng ; Tang, Xulei ; Hu, Ruying ; Su, Qing ; Zhang, Jie ; Zhang, Yi ; Zhao, Zhiyun ; Xu, Yu ; Li, Mian ; Chen, Yuhong ; Wang, Shuangyuan ; Shi, Lixin ; Wan, Qin ; Chen, Gang ; Dai, Meng ; Zhang, Di ; Gao, Zhengnan ; Wang, Guixia ; Shen, Feixia ; Luo, Zuojie ; Qin, Yingfen ; Chen, Li ; Huo, Yanan ; Li, Qiang ; Ye, Zhen ; Zhang, Yinfei ; Liu, Chao ; Wang, Youmin ; Wu, Shengli ; Yang, Tao ; Deng, Huacong ; Chen, Lulu ; Zhao, Jiajun ; Mu, Yiming ; Yan, Li ; Wang, Weiqing ; Ning, Guang ; Bi, Yufang ; Lu, Jieli ; Xu, Min</creatorcontrib><description>Excessive adiposity in adulthood is positively associated with the risk of cardiovascular disease (CVD). However, it is less studied how the risk is separately explained by early adulthood weight and later weight change, especially in Asian ancestries.
This study included 121160 participants in a large population-based cohort in China. Body weight at 20 and 40 years of age wase self-reported. Information on CVD history was obtained through standard questionnaires.
The odds ratios (ORs) were 1.20 (95% CI, 1.10–1.31) for coronary heart disease (CHD), 1.74 (95% CI, 1.36–2.22) for myocardial infarction (MI), 1.14 (95% CI, 0.99–1.32) for stroke and 1.21 (95% CI, 1.12–1.31) for total CVD among individuals with early overweight, and became more prominent for early obesity. Meanwhile, A moderate weight gain of 2.5 kg between early adulthood and midlife significantly increased the risk of CHD (OR: 1.18, 95% CI: 1.05–1.32), stroke (OR: 1.19, 95% CI: 1.03–1.38) and total CVD (OR: 1.15, 95% CI: 1.04–1.27), and the risk escalated with higher amounts of weight gain. Conversely, a weight loss of 2.5 kg conferred lower risk of CVD compared with a stable weight. In further cross-analysis, participants with early adulthood overweight or obesity and significant weight gain afterwards exhibited the greatest risk of CVD.
High early adulthood BMI and subsequent weight gain had both independent and combined effect on the risk of CVD after midlife. Therefore, weight management should start before early adulthood, and emphasized throughout adulthood for CVD prevention.
•High early adulthood BMI and subsequent weight gain were independently and jointly associated with increased risk of CVD.•Attaining a weight loss of 2.5 kg or more might mitigate the CVD risk posed by excessive adiposity in early adulthood.•Weight management should start before early adulthood, and continue throughout adulthood in terms of CVD prevention.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2021.02.086</identifier><identifier>PMID: 33667580</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cardiovascular disease ; Early adulthood ; Obesity</subject><ispartof>International journal of cardiology, 2021-06, Vol.332, p.209-215</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-c8b5ac7b5809e7dc27051b3ca94adf1e64ca47595f44d4e0c72b949de1d95d823</citedby><cites>FETCH-LOGICAL-c362t-c8b5ac7b5809e7dc27051b3ca94adf1e64ca47595f44d4e0c72b949de1d95d823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2021.02.086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33667580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yuanyue</creatorcontrib><creatorcontrib>Zheng, Ruizhi</creatorcontrib><creatorcontrib>Hu, Chunyan</creatorcontrib><creatorcontrib>Qin, Guijun</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Wang, Tiange</creatorcontrib><creatorcontrib>Yu, Xuefeng</creatorcontrib><creatorcontrib>Tang, Xulei</creatorcontrib><creatorcontrib>Hu, Ruying</creatorcontrib><creatorcontrib>Su, Qing</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Zhao, Zhiyun</creatorcontrib><creatorcontrib>Xu, Yu</creatorcontrib><creatorcontrib>Li, Mian</creatorcontrib><creatorcontrib>Chen, Yuhong</creatorcontrib><creatorcontrib>Wang, Shuangyuan</creatorcontrib><creatorcontrib>Shi, Lixin</creatorcontrib><creatorcontrib>Wan, Qin</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Dai, Meng</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Gao, Zhengnan</creatorcontrib><creatorcontrib>Wang, Guixia</creatorcontrib><creatorcontrib>Shen, Feixia</creatorcontrib><creatorcontrib>Luo, Zuojie</creatorcontrib><creatorcontrib>Qin, Yingfen</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Huo, Yanan</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Ye, Zhen</creatorcontrib><creatorcontrib>Zhang, Yinfei</creatorcontrib><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Wang, Youmin</creatorcontrib><creatorcontrib>Wu, Shengli</creatorcontrib><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Deng, Huacong</creatorcontrib><creatorcontrib>Chen, Lulu</creatorcontrib><creatorcontrib>Zhao, Jiajun</creatorcontrib><creatorcontrib>Mu, Yiming</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Bi, Yufang</creatorcontrib><creatorcontrib>Lu, Jieli</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><title>Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Excessive adiposity in adulthood is positively associated with the risk of cardiovascular disease (CVD). However, it is less studied how the risk is separately explained by early adulthood weight and later weight change, especially in Asian ancestries.
This study included 121160 participants in a large population-based cohort in China. Body weight at 20 and 40 years of age wase self-reported. Information on CVD history was obtained through standard questionnaires.
The odds ratios (ORs) were 1.20 (95% CI, 1.10–1.31) for coronary heart disease (CHD), 1.74 (95% CI, 1.36–2.22) for myocardial infarction (MI), 1.14 (95% CI, 0.99–1.32) for stroke and 1.21 (95% CI, 1.12–1.31) for total CVD among individuals with early overweight, and became more prominent for early obesity. Meanwhile, A moderate weight gain of 2.5 kg between early adulthood and midlife significantly increased the risk of CHD (OR: 1.18, 95% CI: 1.05–1.32), stroke (OR: 1.19, 95% CI: 1.03–1.38) and total CVD (OR: 1.15, 95% CI: 1.04–1.27), and the risk escalated with higher amounts of weight gain. Conversely, a weight loss of 2.5 kg conferred lower risk of CVD compared with a stable weight. In further cross-analysis, participants with early adulthood overweight or obesity and significant weight gain afterwards exhibited the greatest risk of CVD.
High early adulthood BMI and subsequent weight gain had both independent and combined effect on the risk of CVD after midlife. Therefore, weight management should start before early adulthood, and emphasized throughout adulthood for CVD prevention.
•High early adulthood BMI and subsequent weight gain were independently and jointly associated with increased risk of CVD.•Attaining a weight loss of 2.5 kg or more might mitigate the CVD risk posed by excessive adiposity in early adulthood.•Weight management should start before early adulthood, and continue throughout adulthood in terms of CVD prevention.</description><subject>Cardiovascular disease</subject><subject>Early adulthood</subject><subject>Obesity</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQhkVpaLZp_0EpOvZiR5Jly-qhsCxJEwgNhPQsZGm8q8VrpRo5YQ_57_GySY49DQzPfLwPId84Kznjzfm2DFtnky8FE7xkomRt84EseKtkwVUtP5LFjKmiFqo6JZ8Rt4wxqXX7iZxWVdOoumUL8rxEjC7YHOJIY0_BpmFPrZ-GvInR0ycI602mdvQUpw7h3wRjfuu6jR3XQJ9C3tDDKyE-WnTTYBP1AcEi4E96GUYfxjXSPsUdvbtYru6vb_9QzJPffyEnvR0Qvr7WM_L38uJ-dVXc3P6-Xi1vClc1Iheu7WrrVDd_rEF5JxSreVc5q6X1PYdGOitVreteSi-BOSU6LbUH7nXtW1GdkR_HvQ8pzgkwm11AB8NgR4gTGiF1K3XFKz2j8oi6FBET9OYhhZ1Ne8OZOYg3W3MUbw7iDRNmFj-PfX-9MHU78O9Db6Zn4NcRgDnnY4Bk0AUYHfiQwGXjY_j_hRcQXZhc</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Zhu, Yuanyue</creator><creator>Zheng, Ruizhi</creator><creator>Hu, Chunyan</creator><creator>Qin, Guijun</creator><creator>Wang, Bin</creator><creator>Wang, Tiange</creator><creator>Yu, Xuefeng</creator><creator>Tang, Xulei</creator><creator>Hu, Ruying</creator><creator>Su, Qing</creator><creator>Zhang, Jie</creator><creator>Zhang, Yi</creator><creator>Zhao, Zhiyun</creator><creator>Xu, Yu</creator><creator>Li, Mian</creator><creator>Chen, Yuhong</creator><creator>Wang, Shuangyuan</creator><creator>Shi, Lixin</creator><creator>Wan, Qin</creator><creator>Chen, Gang</creator><creator>Dai, Meng</creator><creator>Zhang, Di</creator><creator>Gao, Zhengnan</creator><creator>Wang, Guixia</creator><creator>Shen, Feixia</creator><creator>Luo, Zuojie</creator><creator>Qin, Yingfen</creator><creator>Chen, Li</creator><creator>Huo, Yanan</creator><creator>Li, Qiang</creator><creator>Ye, Zhen</creator><creator>Zhang, Yinfei</creator><creator>Liu, Chao</creator><creator>Wang, Youmin</creator><creator>Wu, Shengli</creator><creator>Yang, Tao</creator><creator>Deng, Huacong</creator><creator>Chen, Lulu</creator><creator>Zhao, Jiajun</creator><creator>Mu, Yiming</creator><creator>Yan, Li</creator><creator>Wang, Weiqing</creator><creator>Ning, Guang</creator><creator>Bi, Yufang</creator><creator>Lu, Jieli</creator><creator>Xu, Min</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210601</creationdate><title>Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study</title><author>Zhu, Yuanyue ; Zheng, Ruizhi ; Hu, Chunyan ; Qin, Guijun ; Wang, Bin ; Wang, Tiange ; Yu, Xuefeng ; Tang, Xulei ; Hu, Ruying ; Su, Qing ; Zhang, Jie ; Zhang, Yi ; Zhao, Zhiyun ; Xu, Yu ; Li, Mian ; Chen, Yuhong ; Wang, Shuangyuan ; Shi, Lixin ; Wan, Qin ; Chen, Gang ; Dai, Meng ; Zhang, Di ; Gao, Zhengnan ; Wang, Guixia ; Shen, Feixia ; Luo, Zuojie ; Qin, Yingfen ; Chen, Li ; Huo, Yanan ; Li, Qiang ; Ye, Zhen ; Zhang, Yinfei ; Liu, Chao ; Wang, Youmin ; Wu, Shengli ; Yang, Tao ; Deng, Huacong ; Chen, Lulu ; Zhao, Jiajun ; Mu, Yiming ; Yan, Li ; Wang, Weiqing ; Ning, Guang ; Bi, Yufang ; Lu, Jieli ; Xu, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-c8b5ac7b5809e7dc27051b3ca94adf1e64ca47595f44d4e0c72b949de1d95d823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiovascular disease</topic><topic>Early adulthood</topic><topic>Obesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Yuanyue</creatorcontrib><creatorcontrib>Zheng, Ruizhi</creatorcontrib><creatorcontrib>Hu, Chunyan</creatorcontrib><creatorcontrib>Qin, Guijun</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Wang, Tiange</creatorcontrib><creatorcontrib>Yu, Xuefeng</creatorcontrib><creatorcontrib>Tang, Xulei</creatorcontrib><creatorcontrib>Hu, Ruying</creatorcontrib><creatorcontrib>Su, Qing</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Zhao, Zhiyun</creatorcontrib><creatorcontrib>Xu, Yu</creatorcontrib><creatorcontrib>Li, Mian</creatorcontrib><creatorcontrib>Chen, Yuhong</creatorcontrib><creatorcontrib>Wang, Shuangyuan</creatorcontrib><creatorcontrib>Shi, Lixin</creatorcontrib><creatorcontrib>Wan, Qin</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Dai, Meng</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Gao, Zhengnan</creatorcontrib><creatorcontrib>Wang, Guixia</creatorcontrib><creatorcontrib>Shen, Feixia</creatorcontrib><creatorcontrib>Luo, Zuojie</creatorcontrib><creatorcontrib>Qin, Yingfen</creatorcontrib><creatorcontrib>Chen, Li</creatorcontrib><creatorcontrib>Huo, Yanan</creatorcontrib><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Ye, Zhen</creatorcontrib><creatorcontrib>Zhang, Yinfei</creatorcontrib><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Wang, Youmin</creatorcontrib><creatorcontrib>Wu, Shengli</creatorcontrib><creatorcontrib>Yang, Tao</creatorcontrib><creatorcontrib>Deng, Huacong</creatorcontrib><creatorcontrib>Chen, Lulu</creatorcontrib><creatorcontrib>Zhao, Jiajun</creatorcontrib><creatorcontrib>Mu, Yiming</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Bi, Yufang</creatorcontrib><creatorcontrib>Lu, Jieli</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Yuanyue</au><au>Zheng, Ruizhi</au><au>Hu, Chunyan</au><au>Qin, Guijun</au><au>Wang, Bin</au><au>Wang, Tiange</au><au>Yu, Xuefeng</au><au>Tang, Xulei</au><au>Hu, Ruying</au><au>Su, Qing</au><au>Zhang, Jie</au><au>Zhang, Yi</au><au>Zhao, Zhiyun</au><au>Xu, Yu</au><au>Li, Mian</au><au>Chen, Yuhong</au><au>Wang, Shuangyuan</au><au>Shi, Lixin</au><au>Wan, Qin</au><au>Chen, Gang</au><au>Dai, Meng</au><au>Zhang, Di</au><au>Gao, Zhengnan</au><au>Wang, Guixia</au><au>Shen, Feixia</au><au>Luo, Zuojie</au><au>Qin, Yingfen</au><au>Chen, Li</au><au>Huo, Yanan</au><au>Li, Qiang</au><au>Ye, Zhen</au><au>Zhang, Yinfei</au><au>Liu, Chao</au><au>Wang, Youmin</au><au>Wu, Shengli</au><au>Yang, Tao</au><au>Deng, Huacong</au><au>Chen, Lulu</au><au>Zhao, Jiajun</au><au>Mu, Yiming</au><au>Yan, Li</au><au>Wang, Weiqing</au><au>Ning, Guang</au><au>Bi, Yufang</au><au>Lu, Jieli</au><au>Xu, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>332</volume><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Excessive adiposity in adulthood is positively associated with the risk of cardiovascular disease (CVD). However, it is less studied how the risk is separately explained by early adulthood weight and later weight change, especially in Asian ancestries.
This study included 121160 participants in a large population-based cohort in China. Body weight at 20 and 40 years of age wase self-reported. Information on CVD history was obtained through standard questionnaires.
The odds ratios (ORs) were 1.20 (95% CI, 1.10–1.31) for coronary heart disease (CHD), 1.74 (95% CI, 1.36–2.22) for myocardial infarction (MI), 1.14 (95% CI, 0.99–1.32) for stroke and 1.21 (95% CI, 1.12–1.31) for total CVD among individuals with early overweight, and became more prominent for early obesity. Meanwhile, A moderate weight gain of 2.5 kg between early adulthood and midlife significantly increased the risk of CHD (OR: 1.18, 95% CI: 1.05–1.32), stroke (OR: 1.19, 95% CI: 1.03–1.38) and total CVD (OR: 1.15, 95% CI: 1.04–1.27), and the risk escalated with higher amounts of weight gain. Conversely, a weight loss of 2.5 kg conferred lower risk of CVD compared with a stable weight. In further cross-analysis, participants with early adulthood overweight or obesity and significant weight gain afterwards exhibited the greatest risk of CVD.
High early adulthood BMI and subsequent weight gain had both independent and combined effect on the risk of CVD after midlife. Therefore, weight management should start before early adulthood, and emphasized throughout adulthood for CVD prevention.
•High early adulthood BMI and subsequent weight gain were independently and jointly associated with increased risk of CVD.•Attaining a weight loss of 2.5 kg or more might mitigate the CVD risk posed by excessive adiposity in early adulthood.•Weight management should start before early adulthood, and continue throughout adulthood in terms of CVD prevention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33667580</pmid><doi>10.1016/j.ijcard.2021.02.086</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-5273 |
| ispartof | International journal of cardiology, 2021-06, Vol.332, p.209-215 |
| issn | 0167-5273 1874-1754 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2498493139 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Cardiovascular disease Early adulthood Obesity |
| title | Association of early adulthood weight and subsequent weight change with cardiovascular diseases: Findings from REACTION study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A40%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20early%20adulthood%20weight%20and%20subsequent%20weight%20change%20with%20cardiovascular%20diseases:%20Findings%20from%20REACTION%20study&rft.jtitle=International%20journal%20of%20cardiology&rft.au=Zhu,%20Yuanyue&rft.date=2021-06-01&rft.volume=332&rft.spage=209&rft.epage=215&rft.pages=209-215&rft.issn=0167-5273&rft.eissn=1874-1754&rft_id=info:doi/10.1016/j.ijcard.2021.02.086&rft_dat=%3Cproquest_cross%3E2498493139%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2498493139&rft_id=info:pmid/33667580&rft_els_id=S0167527321003971&rfr_iscdi=true |