Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves significant accumulation of type I collagen (Col1). However, the precise molecular and mechanistic contribution of Col1 in PDAC progression remains unknown. Activated pancreatic stellate cells/αSMA+ myofibroblasts are...

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Veröffentlicht in:	Cancer cell 2021-04, Vol.39 (4), p.548-565.e6
Hauptverfasser:	Chen, Yang, Kim, Jiha, Yang, Sujuan, Wang, Huamin, Wu, Chang-Jiun, Sugimoto, Hikaru, LeBleu, Valerie S., Kalluri, Raghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B cells Carcinoma, Pancreatic Ductal - pathology CD8-Positive T-Lymphocytes - pathology Cell Line, Tumor Collagen Type I - metabolism Disease Models, Animal extracellular matrix fibroblasts genetically engineered mouse models Mice myeloid-derived suppressor cells (MDSCs) Myofibroblasts - pathology pancreatic ductal adenocarcinoma (PDAC) Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Stellate Cells - pathology T cells tumor immunology tumor microenvironment Tumor Microenvironment - immunology type I collagen
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