Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion

Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history an...

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Veröffentlicht in:Cell stem cell 2021-03, Vol.28 (3), p.359-361
Hauptverfasser: Luque Paz, Damien, Ashcroft, Peter, Skoda, Radek C.
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Skoda, Radek C.
description Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation. Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell, Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation.
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title Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion
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