Volumetric evaluation of CT images of adrenal glands in primary aldosteronism
Objectives To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy....
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| Veröffentlicht in: | Journal of endocrinological investigation 2021-11, Vol.44 (11), p.2359-2366 |
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| creator | Velema, M. S. Canu, L. Dekkers, T. Hermus, A. R. M. M. Timmers, H. J. L. M. Schultze Kool, L. J. Groenewoud, H. J. M. M. Jacobs, C. Deinum, J. |
| description | Objectives
To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.
Methods
We retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volumes with published normal values.
Results
Adrenal volume was higher for the left than the right adrenal (mean and SD: 6.49 ± 2.77 ml versus 5.25 ± 1.87 ml for the right adrenal;
p
|
| doi_str_mv | 10.1007/s40618-021-01540-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2498485042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2498485042</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-543630993de14225a0999108fd469400ccecfdcfc8c5cdca2a5f8a8057137f843</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EolD4ARYoEhs2gfHbWaKKl1TEprC1jONUqZK42AkSf49LykMsWHmsOXPtOQidYLjAAPIyMhBY5UBwDpgzyPkOOsCSQK6oEru_6gk6jHEFQCVVch9NKBVCKMkO0MOzb4bW9aG2mXszzWD62neZr7LZIqtbs3RxczFlcJ1psmVjujJmdZetQ-qG98w0pY-9C76rY3uE9irTRHe8Pafo6eZ6MbvL54-397OreW4ZLvqcMyooFAUtHWaEcJPqAoOqSiYKBmCts1VpK6sst6U1xPBKGQVcYiorxegUnY-56-BfBxd73dbRuib9zvkhasIKxRQHRhJ69gdd-SGkXRLFUySRAmiiyEjZ4GMMrtLb_TQGvZGtR9k6ydafsjVPQ6fb6OGldeX3yJfdBNARiKnVLV34efuf2A8gpYkZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580527603</pqid></control><display><type>article</type><title>Volumetric evaluation of CT images of adrenal glands in primary aldosteronism</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Velema, M. S. ; Canu, L. ; Dekkers, T. ; Hermus, A. R. M. M. ; Timmers, H. J. L. M. ; Schultze Kool, L. J. ; Groenewoud, H. J. M. M. ; Jacobs, C. ; Deinum, J.</creator><creatorcontrib>Velema, M. S. ; Canu, L. ; Dekkers, T. ; Hermus, A. R. M. M. ; Timmers, H. J. L. M. ; Schultze Kool, L. J. ; Groenewoud, H. J. M. M. ; Jacobs, C. ; Deinum, J. ; SPARTACUS Investigators ; for the SPARTACUS Investigators</creatorcontrib><description>Objectives
To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.
Methods
We retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volumes with published normal values.
Results
Adrenal volume was higher for the left than the right adrenal (mean and SD: 6.49 ± 2.77 ml versus 5.25 ± 1.87 ml for the right adrenal;
p
< 0.001). Concordance between volumetry and AVS in subtyping was 58.8%, versus 51.8% between conventional CT results and AVS (
p
= NS). The volumes of the contralateral adrenals in the patients with unilateral disease (right 4.78 ± 1.37 ml; left 6.00 ± 2.73 ml) were higher than those of healthy controls reported in the literature (right 3.62 ± 1.23 ml
p
< 0.001; left 4.84 ± 1.67 ml
p
= 0.02). In a multivariable analysis the contralateral volume was not associated with biochemical or clinical success, nor with the defined daily doses of antihypertensive agents at 1 year follow-up.
Conclusions
Volumetry of the adrenal glands is not superior to current assessment of adrenal size by CT for subtyping patients with PA. Furthermore, in patients with unilateral disease the size of the contralateral adrenal is enlarged but its size is not associated with outcome.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-021-01540-5</identifier><identifier>PMID: 33666874</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adrenal glands ; Adrenal Glands - blood supply ; Adrenal Glands - diagnostic imaging ; Adrenal Glands - pathology ; Adrenalectomy ; Aldosterone - blood ; Antihypertensive Agents - therapeutic use ; Antihypertensives ; Cone-Beam Computed Tomography - methods ; Cone-Beam Computed Tomography - statistics & numerical data ; Correlation of Data ; Endocrine disorders ; Endocrinology ; Female ; Humans ; Hyperaldosteronism - blood ; Hyperaldosteronism - classification ; Hyperaldosteronism - diagnosis ; Hyperaldosteronism - physiopathology ; Hypertension - etiology ; Hypertension - therapy ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Netherlands - epidemiology ; Organ Size ; Original Article ; Patients ; Prognosis ; Reference Values ; Retrospective Studies ; Tomography, X-Ray Computed - methods ; Tomography, X-Ray Computed - statistics & numerical data</subject><ispartof>Journal of endocrinological investigation, 2021-11, Vol.44 (11), p.2359-2366</ispartof><rights>Italian Society of Endocrinology (SIE) 2021</rights><rights>2021. Italian Society of Endocrinology (SIE).</rights><rights>Italian Society of Endocrinology (SIE) 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-543630993de14225a0999108fd469400ccecfdcfc8c5cdca2a5f8a8057137f843</citedby><cites>FETCH-LOGICAL-c419t-543630993de14225a0999108fd469400ccecfdcfc8c5cdca2a5f8a8057137f843</cites><orcidid>0000-0001-6799-7958</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-021-01540-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-021-01540-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33666874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velema, M. S.</creatorcontrib><creatorcontrib>Canu, L.</creatorcontrib><creatorcontrib>Dekkers, T.</creatorcontrib><creatorcontrib>Hermus, A. R. M. M.</creatorcontrib><creatorcontrib>Timmers, H. J. L. M.</creatorcontrib><creatorcontrib>Schultze Kool, L. J.</creatorcontrib><creatorcontrib>Groenewoud, H. J. M. M.</creatorcontrib><creatorcontrib>Jacobs, C.</creatorcontrib><creatorcontrib>Deinum, J.</creatorcontrib><creatorcontrib>SPARTACUS Investigators</creatorcontrib><creatorcontrib>for the SPARTACUS Investigators</creatorcontrib><title>Volumetric evaluation of CT images of adrenal glands in primary aldosteronism</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Objectives
To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.
Methods
We retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volumes with published normal values.
Results
Adrenal volume was higher for the left than the right adrenal (mean and SD: 6.49 ± 2.77 ml versus 5.25 ± 1.87 ml for the right adrenal;
p
< 0.001). Concordance between volumetry and AVS in subtyping was 58.8%, versus 51.8% between conventional CT results and AVS (
p
= NS). The volumes of the contralateral adrenals in the patients with unilateral disease (right 4.78 ± 1.37 ml; left 6.00 ± 2.73 ml) were higher than those of healthy controls reported in the literature (right 3.62 ± 1.23 ml
p
< 0.001; left 4.84 ± 1.67 ml
p
= 0.02). In a multivariable analysis the contralateral volume was not associated with biochemical or clinical success, nor with the defined daily doses of antihypertensive agents at 1 year follow-up.
Conclusions
Volumetry of the adrenal glands is not superior to current assessment of adrenal size by CT for subtyping patients with PA. Furthermore, in patients with unilateral disease the size of the contralateral adrenal is enlarged but its size is not associated with outcome.</description><subject>Adrenal glands</subject><subject>Adrenal Glands - blood supply</subject><subject>Adrenal Glands - diagnostic imaging</subject><subject>Adrenal Glands - pathology</subject><subject>Adrenalectomy</subject><subject>Aldosterone - blood</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Cone-Beam Computed Tomography - methods</subject><subject>Cone-Beam Computed Tomography - statistics & numerical data</subject><subject>Correlation of Data</subject><subject>Endocrine disorders</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperaldosteronism - blood</subject><subject>Hyperaldosteronism - classification</subject><subject>Hyperaldosteronism - diagnosis</subject><subject>Hyperaldosteronism - physiopathology</subject><subject>Hypertension - etiology</subject><subject>Hypertension - therapy</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Organ Size</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tomography, X-Ray Computed - statistics & numerical data</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EolD4ARYoEhs2gfHbWaKKl1TEprC1jONUqZK42AkSf49LykMsWHmsOXPtOQidYLjAAPIyMhBY5UBwDpgzyPkOOsCSQK6oEru_6gk6jHEFQCVVch9NKBVCKMkO0MOzb4bW9aG2mXszzWD62neZr7LZIqtbs3RxczFlcJ1psmVjujJmdZetQ-qG98w0pY-9C76rY3uE9irTRHe8Pafo6eZ6MbvL54-397OreW4ZLvqcMyooFAUtHWaEcJPqAoOqSiYKBmCts1VpK6sst6U1xPBKGQVcYiorxegUnY-56-BfBxd73dbRuib9zvkhasIKxRQHRhJ69gdd-SGkXRLFUySRAmiiyEjZ4GMMrtLb_TQGvZGtR9k6ydafsjVPQ6fb6OGldeX3yJfdBNARiKnVLV34efuf2A8gpYkZ</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Velema, M. S.</creator><creator>Canu, L.</creator><creator>Dekkers, T.</creator><creator>Hermus, A. R. M. M.</creator><creator>Timmers, H. J. L. M.</creator><creator>Schultze Kool, L. J.</creator><creator>Groenewoud, H. J. M. M.</creator><creator>Jacobs, C.</creator><creator>Deinum, J.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6799-7958</orcidid></search><sort><creationdate>20211101</creationdate><title>Volumetric evaluation of CT images of adrenal glands in primary aldosteronism</title><author>Velema, M. S. ; Canu, L. ; Dekkers, T. ; Hermus, A. R. M. M. ; Timmers, H. J. L. M. ; Schultze Kool, L. J. ; Groenewoud, H. J. M. M. ; Jacobs, C. ; Deinum, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-543630993de14225a0999108fd469400ccecfdcfc8c5cdca2a5f8a8057137f843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adrenal glands</topic><topic>Adrenal Glands - blood supply</topic><topic>Adrenal Glands - diagnostic imaging</topic><topic>Adrenal Glands - pathology</topic><topic>Adrenalectomy</topic><topic>Aldosterone - blood</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Cone-Beam Computed Tomography - methods</topic><topic>Cone-Beam Computed Tomography - statistics & numerical data</topic><topic>Correlation of Data</topic><topic>Endocrine disorders</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperaldosteronism - blood</topic><topic>Hyperaldosteronism - classification</topic><topic>Hyperaldosteronism - diagnosis</topic><topic>Hyperaldosteronism - physiopathology</topic><topic>Hypertension - etiology</topic><topic>Hypertension - therapy</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Organ Size</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tomography, X-Ray Computed - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velema, M. S.</creatorcontrib><creatorcontrib>Canu, L.</creatorcontrib><creatorcontrib>Dekkers, T.</creatorcontrib><creatorcontrib>Hermus, A. R. M. M.</creatorcontrib><creatorcontrib>Timmers, H. J. L. M.</creatorcontrib><creatorcontrib>Schultze Kool, L. J.</creatorcontrib><creatorcontrib>Groenewoud, H. J. M. M.</creatorcontrib><creatorcontrib>Jacobs, C.</creatorcontrib><creatorcontrib>Deinum, J.</creatorcontrib><creatorcontrib>SPARTACUS Investigators</creatorcontrib><creatorcontrib>for the SPARTACUS Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velema, M. S.</au><au>Canu, L.</au><au>Dekkers, T.</au><au>Hermus, A. R. M. M.</au><au>Timmers, H. J. L. M.</au><au>Schultze Kool, L. J.</au><au>Groenewoud, H. J. M. M.</au><au>Jacobs, C.</au><au>Deinum, J.</au><aucorp>SPARTACUS Investigators</aucorp><aucorp>for the SPARTACUS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volumetric evaluation of CT images of adrenal glands in primary aldosteronism</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>44</volume><issue>11</issue><spage>2359</spage><epage>2366</epage><pages>2359-2366</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Objectives
To investigate whether adrenal volumetry provides better agreement with adrenal vein sampling (AVS) than conventional CT for subtyping PA. Furthermore, we evaluated whether the size of this contralateral adrenal was a prognostic factor for clinical outcome after unilateral adrenalectomy.
Methods
We retrospectively analyzed volumes of both adrenal glands of the 180 CT-scans (88/180 with unilateral and 92/180 with bilateral disease) of the patients with PA included in the SPARTACUS trial of which 85 also had undergone an AVS. In addition, we examined CT-scans of 20 healthy individuals to compare adrenal volumes with published normal values.
Results
Adrenal volume was higher for the left than the right adrenal (mean and SD: 6.49 ± 2.77 ml versus 5.25 ± 1.87 ml for the right adrenal;
p
< 0.001). Concordance between volumetry and AVS in subtyping was 58.8%, versus 51.8% between conventional CT results and AVS (
p
= NS). The volumes of the contralateral adrenals in the patients with unilateral disease (right 4.78 ± 1.37 ml; left 6.00 ± 2.73 ml) were higher than those of healthy controls reported in the literature (right 3.62 ± 1.23 ml
p
< 0.001; left 4.84 ± 1.67 ml
p
= 0.02). In a multivariable analysis the contralateral volume was not associated with biochemical or clinical success, nor with the defined daily doses of antihypertensive agents at 1 year follow-up.
Conclusions
Volumetry of the adrenal glands is not superior to current assessment of adrenal size by CT for subtyping patients with PA. Furthermore, in patients with unilateral disease the size of the contralateral adrenal is enlarged but its size is not associated with outcome.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33666874</pmid><doi>10.1007/s40618-021-01540-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6799-7958</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal glands Adrenal Glands - blood supply Adrenal Glands - diagnostic imaging Adrenal Glands - pathology Adrenalectomy Aldosterone - blood Antihypertensive Agents - therapeutic use Antihypertensives Cone-Beam Computed Tomography - methods Cone-Beam Computed Tomography - statistics & numerical data Correlation of Data Endocrine disorders Endocrinology Female Humans Hyperaldosteronism - blood Hyperaldosteronism - classification Hyperaldosteronism - diagnosis Hyperaldosteronism - physiopathology Hypertension - etiology Hypertension - therapy Internal Medicine Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Netherlands - epidemiology Organ Size Original Article Patients Prognosis Reference Values Retrospective Studies Tomography, X-Ray Computed - methods Tomography, X-Ray Computed - statistics & numerical data |
| title | Volumetric evaluation of CT images of adrenal glands in primary aldosteronism |
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