Effect of hemocoagulase agkistrodon on coagulation status in patients with traumatic brain injury in vitro
To analyze the effects of hemocoagulase agkistrodon (HCA) on the coagulation status of healthy people and traumatic brain injury (TBI) patients . A total of 10 TBI patients were enrolled from December 2018 to June 2019,and 24 age and sex matched healthy controls were also enrolled. Clinical and path...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2021-03, Vol.101 (8), p.586-590 |
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| creator | Ma, R Ren, J Zhang, Z B Men, J L Deng, Q J |
| description | To analyze the effects of hemocoagulase agkistrodon (HCA) on the coagulation status of healthy people and traumatic brain injury (TBI) patients
.
A total of 10 TBI patients were enrolled from December 2018 to June 2019,and 24 age and sex matched healthy controls were also enrolled. Clinical and pathological data, blood samples of all subjects were collected. Different gradient concentrations of HCA were added to the blood samples which were detected by thromboelastography, and the R value, K value, α angle and MA value of thromboelastography parameters between the two groups were analyzed to explore the effect of HCA on the coagulation status of patients with TBI.
With the increase of HCA concentration in blood samples, the R and K values gradually increased, and the α angles and MA values gradually decreased in both TBI patients group which included 7 males and 3 females, with an median age of 33 (28-39) years old and healthy control group which included 11 males and 13 females, with an median age of 33 (23- |
| doi_str_mv | 10.3760/cma.j.cn112137-20200529-01697 |
| format | Article |
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.
A total of 10 TBI patients were enrolled from December 2018 to June 2019,and 24 age and sex matched healthy controls were also enrolled. Clinical and pathological data, blood samples of all subjects were collected. Different gradient concentrations of HCA were added to the blood samples which were detected by thromboelastography, and the R value, K value, α angle and MA value of thromboelastography parameters between the two groups were analyzed to explore the effect of HCA on the coagulation status of patients with TBI.
With the increase of HCA concentration in blood samples, the R and K values gradually increased, and the α angles and MA values gradually decreased in both TBI patients group which included 7 males and 3 females, with an median age of 33 (28-39) years old and healthy control group which included 11 males and 13 females, with an median age of 33 (23-</description><identifier>ISSN: 0376-2491</identifier><identifier>DOI: 10.3760/cma.j.cn112137-20200529-01697</identifier><identifier>PMID: 33663190</identifier><language>chi</language><publisher>China</publisher><subject>Adult ; Agkistrodon ; Animals ; Batroxobin ; Blood Coagulation ; Brain Injuries, Traumatic ; Female ; Humans ; Male ; Middle Aged ; Thrombelastography</subject><ispartof>Zhong hua yi xue za zhi, 2021-03, Vol.101 (8), p.586-590</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33663190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, R</creatorcontrib><creatorcontrib>Ren, J</creatorcontrib><creatorcontrib>Zhang, Z B</creatorcontrib><creatorcontrib>Men, J L</creatorcontrib><creatorcontrib>Deng, Q J</creatorcontrib><title>Effect of hemocoagulase agkistrodon on coagulation status in patients with traumatic brain injury in vitro</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To analyze the effects of hemocoagulase agkistrodon (HCA) on the coagulation status of healthy people and traumatic brain injury (TBI) patients
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A total of 10 TBI patients were enrolled from December 2018 to June 2019,and 24 age and sex matched healthy controls were also enrolled. Clinical and pathological data, blood samples of all subjects were collected. Different gradient concentrations of HCA were added to the blood samples which were detected by thromboelastography, and the R value, K value, α angle and MA value of thromboelastography parameters between the two groups were analyzed to explore the effect of HCA on the coagulation status of patients with TBI.
With the increase of HCA concentration in blood samples, the R and K values gradually increased, and the α angles and MA values gradually decreased in both TBI patients group which included 7 males and 3 females, with an median age of 33 (28-39) years old and healthy control group which included 11 males and 13 females, with an median age of 33 (23-</description><subject>Adult</subject><subject>Agkistrodon</subject><subject>Animals</subject><subject>Batroxobin</subject><subject>Blood Coagulation</subject><subject>Brain Injuries, Traumatic</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Thrombelastography</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLAzEUhbNQbKn9C5KN4GZqbjKTTJZS6gMKbrof8po247ycZJT-eyNWuHAu53ycxUHoHsiGCU4eTac2zcb0ABSYyCihhBRUZgS4FFdoSRKV0VzCAq1D8JrkgslEwQ1aMMY5A0mWqNnVtTMRDzU-uW4wgzrOrQoOq-OHD3Ea7NDjdJcg-vSHqOIcsO_xmAzXx4C_fTzhOKm5S47BelIp9X0zT-df7sunplt0Xas2uPVFV-jwvDtsX7P9-8vb9mmfjQUnGXBFNWOCGjC6KAtJhcspWGoF5Xkhra2V0FrwAkBKRYwlNejSAhdCEkbYCj381Y7T8Dm7EKvOB-PaVvVumEOVJinzkhWMJvTugs66c7YaJ9-p6Vz9z8N-AEXbarc</recordid><startdate>20210302</startdate><enddate>20210302</enddate><creator>Ma, R</creator><creator>Ren, J</creator><creator>Zhang, Z B</creator><creator>Men, J L</creator><creator>Deng, Q J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20210302</creationdate><title>Effect of hemocoagulase agkistrodon on coagulation status in patients with traumatic brain injury in vitro</title><author>Ma, R ; Ren, J ; Zhang, Z B ; Men, J L ; Deng, Q J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p560-16a2b3372c1cb585927e421d2d726459ddfa7bb7651199a0cd0f1b8d167790303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Agkistrodon</topic><topic>Animals</topic><topic>Batroxobin</topic><topic>Blood Coagulation</topic><topic>Brain Injuries, Traumatic</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Thrombelastography</topic><toplevel>online_resources</toplevel><creatorcontrib>Ma, R</creatorcontrib><creatorcontrib>Ren, J</creatorcontrib><creatorcontrib>Zhang, Z B</creatorcontrib><creatorcontrib>Men, J L</creatorcontrib><creatorcontrib>Deng, Q J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, R</au><au>Ren, J</au><au>Zhang, Z B</au><au>Men, J L</au><au>Deng, Q J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of hemocoagulase agkistrodon on coagulation status in patients with traumatic brain injury in vitro</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2021-03-02</date><risdate>2021</risdate><volume>101</volume><issue>8</issue><spage>586</spage><epage>590</epage><pages>586-590</pages><issn>0376-2491</issn><abstract>To analyze the effects of hemocoagulase agkistrodon (HCA) on the coagulation status of healthy people and traumatic brain injury (TBI) patients
.
A total of 10 TBI patients were enrolled from December 2018 to June 2019,and 24 age and sex matched healthy controls were also enrolled. Clinical and pathological data, blood samples of all subjects were collected. Different gradient concentrations of HCA were added to the blood samples which were detected by thromboelastography, and the R value, K value, α angle and MA value of thromboelastography parameters between the two groups were analyzed to explore the effect of HCA on the coagulation status of patients with TBI.
With the increase of HCA concentration in blood samples, the R and K values gradually increased, and the α angles and MA values gradually decreased in both TBI patients group which included 7 males and 3 females, with an median age of 33 (28-39) years old and healthy control group which included 11 males and 13 females, with an median age of 33 (23-</abstract><cop>China</cop><pmid>33663190</pmid><doi>10.3760/cma.j.cn112137-20200529-01697</doi><tpages>5</tpages></addata></record> |
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| issn | 0376-2491 |
| language | chi |
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| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adult Agkistrodon Animals Batroxobin Blood Coagulation Brain Injuries, Traumatic Female Humans Male Middle Aged Thrombelastography |
| title | Effect of hemocoagulase agkistrodon on coagulation status in patients with traumatic brain injury in vitro |
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