Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma

Recent studies have shown that cleavage and polyadenylation-specific factor 3 (CPSF3) is a promising antitumor therapeutic target, but its potential role in hepatocellular carcinoma (HCC) has not been reported. We explored the expression pattern of CPSF3 in HCC through bioinformatics analysis, quant...

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Veröffentlicht in:	Biomarkers in medicine 2021-04, Vol.15 (5), p.347-358
Hauptverfasser:	Li, Ning, Jiang, Shaotao, Fu, Rongdang, Lv, Jin, Yao, Jiyou, Mai, Jialuo, Hua, Xuefeng, Chen, Huan, Liu, Jie, Lu, Minqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis biomarker Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Case-Control Studies cell cycle Cell Cycle Checkpoints Cell Proliferation Cleavage And Polyadenylation Specificity Factor - genetics Cleavage And Polyadenylation Specificity Factor - metabolism CPSF3 Gene Expression Regulation, Neoplastic Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism hepatocellular carcinoma Humans Life Sciences & Biomedicine Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Medicine, Research & Experimental Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt/GSK-3β Prognosis Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Research & Experimental Medicine Science & Technology Survival Rate Tumor Cells, Cultured
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