Whole family—based Helicobacter pylori eradication is a superior strategy to single‐infected patient treatment approach: A systematic review and meta‐analysis
Background Two critical concerns during Helicobacter pylori (H. pylori) eradication are the successful eradication and recurrence. It is debatable whether whole family‐based H. pylori treatment regimen might have any advantage over single‐infected patient treatment approach in increasing eradication...
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| Veröffentlicht in: | Helicobacter (Cambridge, Mass.) Mass.), 2021-06, Vol.26 (3), p.e12793-n/a |
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| creator | Zhao, Jun‐Bo Yuan, Lin Yu, Xue‐Chun Shao, Qiao‐Qiao Ma, Jing Yu, Miao Wu, Yue Qi, Ya‐Bin Hu, Ruo‐Bing Wei, Pei‐Ru Jia, Bai‐Ling Zhang, Lian‐Zhong Zhang, Yan‐Rui Ding, Song‐Ze |
| description | Background
Two critical concerns during Helicobacter pylori (H. pylori) eradication are the successful eradication and recurrence. It is debatable whether whole family‐based H. pylori treatment regimen might have any advantage over single‐infected patient treatment approach in increasing eradication rate and reducing recurrence rate. We conduct systematic review and meta‐analysis to compare the efficacy of these two treatment regimens in order to provide clinical practice a better option for H. pylori eradication.
Methods
Randomized controlled trials evaluating H. pylori eradication and recurrence in whole family‐based treatment group (WFTG) versus single‐infected patient treatment group (SPTG) were collected from published literature up to July 2020 from common databases. Pooled results were analyzed using either fixed‐effect or random‐effect model. Results were expressed as the odds ratio (OR) and 95% confidence interval (CI).
Results
A total of 1751 relevant articles were identified, and 12 studies were eligible for analysis. Among them: (a) Eight articles including 1198 patients were selected to analyze H. pylori eradication rate, pooled result showed that eradication rate of WFTG was higher than that of SPTG (OR=2.93; 95% CI 1.68–5.13). Stratified analysis showed that H. pylori eradication rate in WFTG were higher over SPTG in children subgroup, but had no difference in spouse subgroup. (b) Six studies including 881 patients were analyzed for recurrence rate between the two groups, pooled analysis showed that the overall recurrence rate of WFTG was lower than that of SPTG (OR=0.3; 95% CI 0.19–0.48). Stratified analysis showed that the recurrence rate in WFTG was lower over SPTG at 6, 12, 18, and more than 24 months post‐treatment subgroups.
Conclusion
Whole family‐based H. pylori treatment can partially increase eradication rate and reduce recurrence rate over single‐infected patient treatment approach, the results provide clinical practice a novel notion for H. pylori eradication and infection prevention. |
| doi_str_mv | 10.1111/hel.12793 |
| format | Article |
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Two critical concerns during Helicobacter pylori (H. pylori) eradication are the successful eradication and recurrence. It is debatable whether whole family‐based H. pylori treatment regimen might have any advantage over single‐infected patient treatment approach in increasing eradication rate and reducing recurrence rate. We conduct systematic review and meta‐analysis to compare the efficacy of these two treatment regimens in order to provide clinical practice a better option for H. pylori eradication.
Methods
Randomized controlled trials evaluating H. pylori eradication and recurrence in whole family‐based treatment group (WFTG) versus single‐infected patient treatment group (SPTG) were collected from published literature up to July 2020 from common databases. Pooled results were analyzed using either fixed‐effect or random‐effect model. Results were expressed as the odds ratio (OR) and 95% confidence interval (CI).
Results
A total of 1751 relevant articles were identified, and 12 studies were eligible for analysis. Among them: (a) Eight articles including 1198 patients were selected to analyze H. pylori eradication rate, pooled result showed that eradication rate of WFTG was higher than that of SPTG (OR=2.93; 95% CI 1.68–5.13). Stratified analysis showed that H. pylori eradication rate in WFTG were higher over SPTG in children subgroup, but had no difference in spouse subgroup. (b) Six studies including 881 patients were analyzed for recurrence rate between the two groups, pooled analysis showed that the overall recurrence rate of WFTG was lower than that of SPTG (OR=0.3; 95% CI 0.19–0.48). Stratified analysis showed that the recurrence rate in WFTG was lower over SPTG at 6, 12, 18, and more than 24 months post‐treatment subgroups.
Conclusion
Whole family‐based H. pylori treatment can partially increase eradication rate and reduce recurrence rate over single‐infected patient treatment approach, the results provide clinical practice a novel notion for H. pylori eradication and infection prevention.</description><identifier>ISSN: 1083-4389</identifier><identifier>EISSN: 1523-5378</identifier><identifier>DOI: 10.1111/hel.12793</identifier><identifier>PMID: 33675089</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Clinical medicine ; Clinical trials ; Confidence intervals ; Eradication ; eradication rate ; family co‐treatment ; H . pylori ; Helicobacter pylori ; Meta-analysis ; Patients ; recurrence rate ; Subgroups ; Systematic review</subject><ispartof>Helicobacter (Cambridge, Mass.), 2021-06, Vol.26 (3), p.e12793-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-c2965688f9e519938544e0b0d33c1e41cd3472079014bcd7f6038f5822aebf5a3</citedby><cites>FETCH-LOGICAL-c3533-c2965688f9e519938544e0b0d33c1e41cd3472079014bcd7f6038f5822aebf5a3</cites><orcidid>0000-0002-3299-7955 ; 0000-0002-4589-6942</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhel.12793$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhel.12793$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33675089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Jun‐Bo</creatorcontrib><creatorcontrib>Yuan, Lin</creatorcontrib><creatorcontrib>Yu, Xue‐Chun</creatorcontrib><creatorcontrib>Shao, Qiao‐Qiao</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Wu, Yue</creatorcontrib><creatorcontrib>Qi, Ya‐Bin</creatorcontrib><creatorcontrib>Hu, Ruo‐Bing</creatorcontrib><creatorcontrib>Wei, Pei‐Ru</creatorcontrib><creatorcontrib>Jia, Bai‐Ling</creatorcontrib><creatorcontrib>Zhang, Lian‐Zhong</creatorcontrib><creatorcontrib>Zhang, Yan‐Rui</creatorcontrib><creatorcontrib>Ding, Song‐Ze</creatorcontrib><title>Whole family—based Helicobacter pylori eradication is a superior strategy to single‐infected patient treatment approach: A systematic review and meta‐analysis</title><title>Helicobacter (Cambridge, Mass.)</title><addtitle>Helicobacter</addtitle><description>Background
Two critical concerns during Helicobacter pylori (H. pylori) eradication are the successful eradication and recurrence. It is debatable whether whole family‐based H. pylori treatment regimen might have any advantage over single‐infected patient treatment approach in increasing eradication rate and reducing recurrence rate. We conduct systematic review and meta‐analysis to compare the efficacy of these two treatment regimens in order to provide clinical practice a better option for H. pylori eradication.
Methods
Randomized controlled trials evaluating H. pylori eradication and recurrence in whole family‐based treatment group (WFTG) versus single‐infected patient treatment group (SPTG) were collected from published literature up to July 2020 from common databases. Pooled results were analyzed using either fixed‐effect or random‐effect model. Results were expressed as the odds ratio (OR) and 95% confidence interval (CI).
Results
A total of 1751 relevant articles were identified, and 12 studies were eligible for analysis. Among them: (a) Eight articles including 1198 patients were selected to analyze H. pylori eradication rate, pooled result showed that eradication rate of WFTG was higher than that of SPTG (OR=2.93; 95% CI 1.68–5.13). Stratified analysis showed that H. pylori eradication rate in WFTG were higher over SPTG in children subgroup, but had no difference in spouse subgroup. (b) Six studies including 881 patients were analyzed for recurrence rate between the two groups, pooled analysis showed that the overall recurrence rate of WFTG was lower than that of SPTG (OR=0.3; 95% CI 0.19–0.48). Stratified analysis showed that the recurrence rate in WFTG was lower over SPTG at 6, 12, 18, and more than 24 months post‐treatment subgroups.
Conclusion
Whole family‐based H. pylori treatment can partially increase eradication rate and reduce recurrence rate over single‐infected patient treatment approach, the results provide clinical practice a novel notion for H. pylori eradication and infection prevention.</description><subject>Clinical medicine</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Eradication</subject><subject>eradication rate</subject><subject>family co‐treatment</subject><subject>H . pylori</subject><subject>Helicobacter pylori</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>recurrence rate</subject><subject>Subgroups</subject><subject>Systematic review</subject><issn>1083-4389</issn><issn>1523-5378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10bFu1TAUBuAIgWgpDLwAssQCQ1o7thObraoKF-lKLCDG6MQ56XXlxMF2WmXrIzD0EfpkfRJcbmFAwovP8J1fR_qL4jWjxyy_kx26Y1Y1mj8pDpmseCl5o57mmSpeCq70QfEixktKqeRCPy8OOK8bSZU-LO6-77xDMsBo3Xp_c9tBxJ5s0FnjOzAJA5lX54MlGKC3BpL1E7GRAInLjMH6QGIKkPBiJcmTaKcLh_c3P-00YF7vyZxXcEokBYQ0Pkwwz8GD2X0gpySuMeGYiSEBryxeE5h6MmKCnAETuDXa-LJ4NoCL-OrxPyq-fTz_erYpt18-fT473ZaGS85LU-la1koNGiXTmispBNKO9pwbhoKZnoumoo2mTHSmb4aacjVIVVWA3SCBHxXv9rn5vh8LxtSONhp0Dib0S2wroZVQTDYs07f_0Eu_hHxvVrKqqRSciqze75UJPsaAQzsHO0JYW0bbh-raXF37u7ps3zwmLt2I_V_5p6sMTvbg2jpc_5_Ubs63-8hfWhmoMg</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Zhao, Jun‐Bo</creator><creator>Yuan, Lin</creator><creator>Yu, Xue‐Chun</creator><creator>Shao, Qiao‐Qiao</creator><creator>Ma, Jing</creator><creator>Yu, Miao</creator><creator>Wu, Yue</creator><creator>Qi, Ya‐Bin</creator><creator>Hu, Ruo‐Bing</creator><creator>Wei, Pei‐Ru</creator><creator>Jia, Bai‐Ling</creator><creator>Zhang, Lian‐Zhong</creator><creator>Zhang, Yan‐Rui</creator><creator>Ding, Song‐Ze</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3299-7955</orcidid><orcidid>https://orcid.org/0000-0002-4589-6942</orcidid></search><sort><creationdate>202106</creationdate><title>Whole family—based Helicobacter pylori eradication is a superior strategy to single‐infected patient treatment approach: A systematic review and meta‐analysis</title><author>Zhao, Jun‐Bo ; Yuan, Lin ; Yu, Xue‐Chun ; Shao, Qiao‐Qiao ; Ma, Jing ; Yu, Miao ; Wu, Yue ; Qi, Ya‐Bin ; Hu, Ruo‐Bing ; Wei, Pei‐Ru ; Jia, Bai‐Ling ; Zhang, Lian‐Zhong ; Zhang, Yan‐Rui ; Ding, Song‐Ze</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-c2965688f9e519938544e0b0d33c1e41cd3472079014bcd7f6038f5822aebf5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical medicine</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Eradication</topic><topic>eradication rate</topic><topic>family co‐treatment</topic><topic>H . pylori</topic><topic>Helicobacter pylori</topic><topic>Meta-analysis</topic><topic>Patients</topic><topic>recurrence rate</topic><topic>Subgroups</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jun‐Bo</creatorcontrib><creatorcontrib>Yuan, Lin</creatorcontrib><creatorcontrib>Yu, Xue‐Chun</creatorcontrib><creatorcontrib>Shao, Qiao‐Qiao</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Yu, Miao</creatorcontrib><creatorcontrib>Wu, Yue</creatorcontrib><creatorcontrib>Qi, Ya‐Bin</creatorcontrib><creatorcontrib>Hu, Ruo‐Bing</creatorcontrib><creatorcontrib>Wei, Pei‐Ru</creatorcontrib><creatorcontrib>Jia, Bai‐Ling</creatorcontrib><creatorcontrib>Zhang, Lian‐Zhong</creatorcontrib><creatorcontrib>Zhang, Yan‐Rui</creatorcontrib><creatorcontrib>Ding, Song‐Ze</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Helicobacter (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jun‐Bo</au><au>Yuan, Lin</au><au>Yu, Xue‐Chun</au><au>Shao, Qiao‐Qiao</au><au>Ma, Jing</au><au>Yu, Miao</au><au>Wu, Yue</au><au>Qi, Ya‐Bin</au><au>Hu, Ruo‐Bing</au><au>Wei, Pei‐Ru</au><au>Jia, Bai‐Ling</au><au>Zhang, Lian‐Zhong</au><au>Zhang, Yan‐Rui</au><au>Ding, Song‐Ze</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole family—based Helicobacter pylori eradication is a superior strategy to single‐infected patient treatment approach: A systematic review and meta‐analysis</atitle><jtitle>Helicobacter (Cambridge, Mass.)</jtitle><addtitle>Helicobacter</addtitle><date>2021-06</date><risdate>2021</risdate><volume>26</volume><issue>3</issue><spage>e12793</spage><epage>n/a</epage><pages>e12793-n/a</pages><issn>1083-4389</issn><eissn>1523-5378</eissn><abstract>Background
Two critical concerns during Helicobacter pylori (H. pylori) eradication are the successful eradication and recurrence. It is debatable whether whole family‐based H. pylori treatment regimen might have any advantage over single‐infected patient treatment approach in increasing eradication rate and reducing recurrence rate. We conduct systematic review and meta‐analysis to compare the efficacy of these two treatment regimens in order to provide clinical practice a better option for H. pylori eradication.
Methods
Randomized controlled trials evaluating H. pylori eradication and recurrence in whole family‐based treatment group (WFTG) versus single‐infected patient treatment group (SPTG) were collected from published literature up to July 2020 from common databases. Pooled results were analyzed using either fixed‐effect or random‐effect model. Results were expressed as the odds ratio (OR) and 95% confidence interval (CI).
Results
A total of 1751 relevant articles were identified, and 12 studies were eligible for analysis. Among them: (a) Eight articles including 1198 patients were selected to analyze H. pylori eradication rate, pooled result showed that eradication rate of WFTG was higher than that of SPTG (OR=2.93; 95% CI 1.68–5.13). Stratified analysis showed that H. pylori eradication rate in WFTG were higher over SPTG in children subgroup, but had no difference in spouse subgroup. (b) Six studies including 881 patients were analyzed for recurrence rate between the two groups, pooled analysis showed that the overall recurrence rate of WFTG was lower than that of SPTG (OR=0.3; 95% CI 0.19–0.48). Stratified analysis showed that the recurrence rate in WFTG was lower over SPTG at 6, 12, 18, and more than 24 months post‐treatment subgroups.
Conclusion
Whole family‐based H. pylori treatment can partially increase eradication rate and reduce recurrence rate over single‐infected patient treatment approach, the results provide clinical practice a novel notion for H. pylori eradication and infection prevention.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33675089</pmid><doi>10.1111/hel.12793</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3299-7955</orcidid><orcidid>https://orcid.org/0000-0002-4589-6942</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | Clinical medicine Clinical trials Confidence intervals Eradication eradication rate family co‐treatment H . pylori Helicobacter pylori Meta-analysis Patients recurrence rate Subgroups Systematic review |
| title | Whole family—based Helicobacter pylori eradication is a superior strategy to single‐infected patient treatment approach: A systematic review and meta‐analysis |
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