Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS

Advances in genome sequencing have identified over 1300 mutations in the SCN1A sodium channel gene that result in genetic epilepsies. However, it still remains unclear how most individual mutations within SCN1A result in seizures. A previous study has shown that the K1270T (KT) mutation, linked to g...

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Veröffentlicht in:	eNeuro 2021-03, Vol.8 (2), p.ENEURO.0394-20.2021, Article 0394
Hauptverfasser:	Das, Antara, Zhu, Bingyao, Xie, Yunyao, Zeng, Lisha, Pham, An T., Neumann, Jonathan C., Safrina, Olga, Benavides, Daniel R., MacGregor, Grant R., Schutte, Soleil S., Hunt, Robert F., O'Dowd, Diane K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Interneurons Life Sciences & Biomedicine Mice Mice, Inbred C57BL Mutation - genetics NAV1.1 Voltage-Gated Sodium Channel - genetics Neurosciences Neurosciences & Neurology New Research Science & Technology Seizures - genetics Seizures, Febrile
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