A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduc...
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| creator | Amlashi, Fazel Isapanah Norouzi, Zahra Sohrabi, Ahmad Shirzad-Aski, Hesamaddin Norouzi, Alireza Ashkbari, Ali Gilani, Naghme Fatemi, Seyed Alireza Besharat, Sima |
| description | Background and objectives
Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization.
Data sources
Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated.
Synthesis methods
Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.
Results
Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45-0.70; P < 0.001), with no publication bias (P = 0.825). The L'Abbe plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.
Conclusions
According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients.
Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=167730. |
| doi_str_mv | 10.1371/journal.pone.0241156 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2497111429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A653700364</galeid><doaj_id>oai_doaj_org_article_1455b675d52b4fcd9648ed96f82e0c8c</doaj_id><sourcerecordid>A653700364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c640t-d6d94a64a03b395969334f77f70321f388a31387420eb56ef1229c64e032d0453</originalsourceid><addsrcrecordid>eNqNkl2L1DAYhYso7rr6D0QKgigyY77b3gjDoO7AwoJftyFN38xkaZsxSXcdf72Z7ThMwYslkITkOSfJm5NlLzGaY1rgDzdu8L1q51vXwxwRhjEXj7JzXFEyEwTRxyfzs-xZCDcIcVoK8TQ7o1TwAqPyPGsXediFCJ2KVucebi3c5apv8g6imql0wC7YkBvncxWC0zZxrs-dyS-htdrVSkfw-XbXOm9z7VrX2z8js3fRCVI6b2wAFeB59sSoNsCLw3iR_fj86fvycnZ1_WW1XFzNtGAozhrRVEwJphCtacUrUVHKTFGYAlGCDS1LRTEtC0YQ1FyAwYRUSQppu0GM04tsNfo2Tt3Irbed8jvplJX3C86vpfLpvS1IzDivRcEbTmpmdFMJVkLqTUkA6VInr4-j13aoO2g09NGrdmI63entRq7drSwqUnKMk8Hbg4F3vwYIUXY2pLq0qgc3BElYVWCMGakS-npE1ypdzfbGJUe9x-VCcFogRAVL1Pw_VGoNdOlHejA2rU8E7yaCxET4HddqCEGuvn19OHv9c8q-OWE3oNq4Ca4d9r8fpiAbQe1dCB7MsXwYyX2Y5SHMch9meQhzkr06Lf1R9C-9CShH4A5qZ4K20Gs4YgghQXhVYp5mBVvaeJ_LpRv6mKTvHy6lfwERDRFp</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2497111429</pqid></control><display><type>article</type><title>A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Amlashi, Fazel Isapanah ; Norouzi, Zahra ; Sohrabi, Ahmad ; Shirzad-Aski, Hesamaddin ; Norouzi, Alireza ; Ashkbari, Ali ; Gilani, Naghme ; Fatemi, Seyed Alireza ; Besharat, Sima</creator><contributor>Galvão, Endi Lanza</contributor><creatorcontrib>Amlashi, Fazel Isapanah ; Norouzi, Zahra ; Sohrabi, Ahmad ; Shirzad-Aski, Hesamaddin ; Norouzi, Alireza ; Ashkbari, Ali ; Gilani, Naghme ; Fatemi, Seyed Alireza ; Besharat, Sima ; Galvão, Endi Lanza</creatorcontrib><description>Background and objectives
Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization.
Data sources
Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated.
Synthesis methods
Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.
Results
Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45-0.70; P < 0.001), with no publication bias (P = 0.825). The L'Abbe plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.
Conclusions
According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients.
Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=167730.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0241156</identifier><identifier>PMID: 33657108</identifier><language>eng</language><publisher>SAN FRANCISCO: Public Library Science</publisher><subject>Analysis ; Biology and Life Sciences ; Care and treatment ; Celiac disease ; Diagnosis ; Helicobacter pylori ; Medicine and Health Sciences ; Multidisciplinary Sciences ; Physical Sciences ; Research and Analysis Methods ; Science & Technology ; Science & Technology - Other Topics</subject><ispartof>PloS one, 2021-03, Vol.16 (3), p.e0241156-e0241156, Article 0241156</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Amlashi et al 2021 Amlashi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000625981500074</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c640t-d6d94a64a03b395969334f77f70321f388a31387420eb56ef1229c64e032d0453</citedby><cites>FETCH-LOGICAL-c640t-d6d94a64a03b395969334f77f70321f388a31387420eb56ef1229c64e032d0453</cites><orcidid>0000-0003-4227-7350 ; 0000-0002-4152-800X ; 0000-0002-0540-6056 ; 0000-0002-7307-0398 ; 0000-0002-8755-2216</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928511/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928511/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,2929,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33657108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Galvão, Endi Lanza</contributor><creatorcontrib>Amlashi, Fazel Isapanah</creatorcontrib><creatorcontrib>Norouzi, Zahra</creatorcontrib><creatorcontrib>Sohrabi, Ahmad</creatorcontrib><creatorcontrib>Shirzad-Aski, Hesamaddin</creatorcontrib><creatorcontrib>Norouzi, Alireza</creatorcontrib><creatorcontrib>Ashkbari, Ali</creatorcontrib><creatorcontrib>Gilani, Naghme</creatorcontrib><creatorcontrib>Fatemi, Seyed Alireza</creatorcontrib><creatorcontrib>Besharat, Sima</creatorcontrib><title>A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease</title><title>PloS one</title><addtitle>PLOS ONE</addtitle><addtitle>PLoS One</addtitle><description>Background and objectives
Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization.
Data sources
Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated.
Synthesis methods
Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.
Results
Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45-0.70; P < 0.001), with no publication bias (P = 0.825). The L'Abbe plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.
Conclusions
According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients.
Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=167730.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Celiac disease</subject><subject>Diagnosis</subject><subject>Helicobacter pylori</subject><subject>Medicine and Health Sciences</subject><subject>Multidisciplinary Sciences</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAYhYso7rr6D0QKgigyY77b3gjDoO7AwoJftyFN38xkaZsxSXcdf72Z7ThMwYslkITkOSfJm5NlLzGaY1rgDzdu8L1q51vXwxwRhjEXj7JzXFEyEwTRxyfzs-xZCDcIcVoK8TQ7o1TwAqPyPGsXediFCJ2KVucebi3c5apv8g6imql0wC7YkBvncxWC0zZxrs-dyS-htdrVSkfw-XbXOm9z7VrX2z8js3fRCVI6b2wAFeB59sSoNsCLw3iR_fj86fvycnZ1_WW1XFzNtGAozhrRVEwJphCtacUrUVHKTFGYAlGCDS1LRTEtC0YQ1FyAwYRUSQppu0GM04tsNfo2Tt3Irbed8jvplJX3C86vpfLpvS1IzDivRcEbTmpmdFMJVkLqTUkA6VInr4-j13aoO2g09NGrdmI63entRq7drSwqUnKMk8Hbg4F3vwYIUXY2pLq0qgc3BElYVWCMGakS-npE1ypdzfbGJUe9x-VCcFogRAVL1Pw_VGoNdOlHejA2rU8E7yaCxET4HddqCEGuvn19OHv9c8q-OWE3oNq4Ca4d9r8fpiAbQe1dCB7MsXwYyX2Y5SHMch9meQhzkr06Lf1R9C-9CShH4A5qZ4K20Gs4YgghQXhVYp5mBVvaeJ_LpRv6mKTvHy6lfwERDRFp</recordid><startdate>20210303</startdate><enddate>20210303</enddate><creator>Amlashi, Fazel Isapanah</creator><creator>Norouzi, Zahra</creator><creator>Sohrabi, Ahmad</creator><creator>Shirzad-Aski, Hesamaddin</creator><creator>Norouzi, Alireza</creator><creator>Ashkbari, Ali</creator><creator>Gilani, Naghme</creator><creator>Fatemi, Seyed Alireza</creator><creator>Besharat, Sima</creator><general>Public Library Science</general><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4227-7350</orcidid><orcidid>https://orcid.org/0000-0002-4152-800X</orcidid><orcidid>https://orcid.org/0000-0002-0540-6056</orcidid><orcidid>https://orcid.org/0000-0002-7307-0398</orcidid><orcidid>https://orcid.org/0000-0002-8755-2216</orcidid></search><sort><creationdate>20210303</creationdate><title>A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease</title><author>Amlashi, Fazel Isapanah ; Norouzi, Zahra ; Sohrabi, Ahmad ; Shirzad-Aski, Hesamaddin ; Norouzi, Alireza ; Ashkbari, Ali ; Gilani, Naghme ; Fatemi, Seyed Alireza ; Besharat, Sima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c640t-d6d94a64a03b395969334f77f70321f388a31387420eb56ef1229c64e032d0453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Celiac disease</topic><topic>Diagnosis</topic><topic>Helicobacter pylori</topic><topic>Medicine and Health Sciences</topic><topic>Multidisciplinary Sciences</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amlashi, Fazel Isapanah</creatorcontrib><creatorcontrib>Norouzi, Zahra</creatorcontrib><creatorcontrib>Sohrabi, Ahmad</creatorcontrib><creatorcontrib>Shirzad-Aski, Hesamaddin</creatorcontrib><creatorcontrib>Norouzi, Alireza</creatorcontrib><creatorcontrib>Ashkbari, Ali</creatorcontrib><creatorcontrib>Gilani, Naghme</creatorcontrib><creatorcontrib>Fatemi, Seyed Alireza</creatorcontrib><creatorcontrib>Besharat, Sima</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amlashi, Fazel Isapanah</au><au>Norouzi, Zahra</au><au>Sohrabi, Ahmad</au><au>Shirzad-Aski, Hesamaddin</au><au>Norouzi, Alireza</au><au>Ashkbari, Ali</au><au>Gilani, Naghme</au><au>Fatemi, Seyed Alireza</au><au>Besharat, Sima</au><au>Galvão, Endi Lanza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease</atitle><jtitle>PloS one</jtitle><stitle>PLOS ONE</stitle><addtitle>PLoS One</addtitle><date>2021-03-03</date><risdate>2021</risdate><volume>16</volume><issue>3</issue><spage>e0241156</spage><epage>e0241156</epage><pages>e0241156-e0241156</pages><artnum>0241156</artnum><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background and objectives
Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization.
Data sources
Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated.
Synthesis methods
Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.
Results
Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45-0.70; P < 0.001), with no publication bias (P = 0.825). The L'Abbe plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.
Conclusions
According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients.
Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=167730.</abstract><cop>SAN FRANCISCO</cop><pub>Public Library Science</pub><pmid>33657108</pmid><doi>10.1371/journal.pone.0241156</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-4227-7350</orcidid><orcidid>https://orcid.org/0000-0002-4152-800X</orcidid><orcidid>https://orcid.org/0000-0002-0540-6056</orcidid><orcidid>https://orcid.org/0000-0002-7307-0398</orcidid><orcidid>https://orcid.org/0000-0002-8755-2216</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Biology and Life Sciences Care and treatment Celiac disease Diagnosis Helicobacter pylori Medicine and Health Sciences Multidisciplinary Sciences Physical Sciences Research and Analysis Methods Science & Technology Science & Technology - Other Topics |
| title | A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease |
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