Establishment of genomic library technology mediated by non-homologous end joining mechanism in Yarrowia lipolytica

Genomic variants libraries are conducive to obtain dominant strains with desirable phenotypic traits. The non-homologous end joining (NHEJ), which enables foreign DNA fragments to be randomly integrated into different chromosomal sites, shows prominent capability in genomic libraries construction. I...

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Veröffentlicht in:	Science China. Life sciences 2021-12, Vol.64 (12), p.2114-2128
Hauptverfasser:	Bai, Qiuyan, Cheng, Shuai, Zhang, Jinlai, Li, Mengxu, Cao, Yingxiu, Yuan, Yingjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Copy number DNA End-Joining Repair Gene Dosage Genomic Library Genomics Homologous recombination Integration Library technology Life Sciences Lycopene Lycopene - metabolism Non-homologous end joining Phenotype Phenotypes Recombinase Research Paper Synthetic Biology - methods Whole Genome Sequencing Yarrowia - genetics Yarrowia - metabolism Yarrowia lipolytica
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