The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the treatment of obesity. However, pharmacologic engagement of this process has proven difficult. Using the Connectivity Map (CMap) approach, we identified the phytochemical hyperforin (HPF) as an anti-obesity agent. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2021-03, Vol.33 (3), p.565-580.e7
Hauptverfasser:	Chen, Suzhen, Liu, Xiaoxiao, Peng, Chao, Tan, Chang, Sun, Honglin, Liu, He, Zhang, Yao, Wu, Ping, Cui, Can, Liu, Chuchu, Yang, Di, Li, Zhiqiang, Lu, Junxi, Guan, Jian, Ke, Xisong, Wang, Renxiao, Bo, Xiaohai, Xu, Xiaojun, Han, Junfeng, Liu, Junli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism AMP-Activated Protein Kinases - metabolism Animals Binding Sites Cold Temperature Dihydrolipoyllysine-Residue Acetyltransferase - chemistry Dihydrolipoyllysine-Residue Acetyltransferase - metabolism Humans Hypericum - chemistry Hypericum - metabolism Mice Mice, Inbred C57BL Mice, Obese Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Molecular Docking Simulation Obesity - drug therapy Obesity - metabolism Obesity - pathology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - metabolism Phloroglucinol - pharmacology Phloroglucinol - therapeutic use Signal Transduction - drug effects Terpenes - chemistry Terpenes - metabolism Terpenes - pharmacology Terpenes - therapeutic use Thermogenesis - drug effects Thermogenesis - genetics Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!