Peripheral ulcerative keratitis
•A review on peripheral ulcerative keratitis (PUK) – its current diagnosis and management.•A systematic approach provided to the readers for workup of a case of PUK.•Emphasis on the rational and judicious use of immunosuppressants in PUK. Peripheral ulcerative keratitis (PUK) is an inflammatory cond...
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| Veröffentlicht in: | Survey of ophthalmology 2021-11, Vol.66 (6), p.977-998 |
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| container_title | Survey of ophthalmology |
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| creator | Gupta, Yogita Kishore, Alisha Kumari, Pooja Balakrishnan, Neelima Lomi, Neiwete Gupta, Noopur Vanathi, M. Tandon, Radhika |
| description | •A review on peripheral ulcerative keratitis (PUK) – its current diagnosis and management.•A systematic approach provided to the readers for workup of a case of PUK.•Emphasis on the rational and judicious use of immunosuppressants in PUK.
Peripheral ulcerative keratitis (PUK) is an inflammatory condition of the peripheral cornea with hallmark features of epithelial defects and stromal destruction as a result of a complex interplay of factors including host autoimmunity and the peculiar anatomic and physiologic features of the peripheral cornea and environmental factors. PUK may be the result of local or systemic causes and infectious or noninfectious causes. Arriving at a specific etiological diagnosis requires a meticulous clinical workup that may include a battery of laboratory and radiological investigations. Management by a team of internists or rheumatologists and ophthalmologists and judicious use of immunosuppressive agents may yield favorable results minimizing adverse effects. We review current clinical knowledge on the diagnosis and management of PUK. |
| doi_str_mv | 10.1016/j.survophthal.2021.02.013 |
| format | Article |
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Peripheral ulcerative keratitis (PUK) is an inflammatory condition of the peripheral cornea with hallmark features of epithelial defects and stromal destruction as a result of a complex interplay of factors including host autoimmunity and the peculiar anatomic and physiologic features of the peripheral cornea and environmental factors. PUK may be the result of local or systemic causes and infectious or noninfectious causes. Arriving at a specific etiological diagnosis requires a meticulous clinical workup that may include a battery of laboratory and radiological investigations. Management by a team of internists or rheumatologists and ophthalmologists and judicious use of immunosuppressive agents may yield favorable results minimizing adverse effects. We review current clinical knowledge on the diagnosis and management of PUK.</description><identifier>ISSN: 0039-6257</identifier><identifier>EISSN: 1879-3304</identifier><identifier>DOI: 10.1016/j.survophthal.2021.02.013</identifier><identifier>PMID: 33657431</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Autoimmunity ; Cornea ; Corneal Ulcer - diagnosis ; Corneal Ulcer - etiology ; Corneal Ulcer - therapy ; Humans ; Immunosuppressive Agents - therapeutic use ; Mooren ulcer ; Mooren's ulcer ; peripheral keratitis ; Peripheral ulcerative keratitis ; PUK</subject><ispartof>Survey of ophthalmology, 2021-11, Vol.66 (6), p.977-998</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-27665dd1fa197e92707b0b582ebae45d6917759fa1d4575cd8dfb239407842643</citedby><cites>FETCH-LOGICAL-c377t-27665dd1fa197e92707b0b582ebae45d6917759fa1d4575cd8dfb239407842643</cites><orcidid>0000-0001-7365-5532 ; 0000-0002-2479-797X ; 0000-0001-8022-6656 ; 0000-0001-9554-9933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.survophthal.2021.02.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33657431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Yogita</creatorcontrib><creatorcontrib>Kishore, Alisha</creatorcontrib><creatorcontrib>Kumari, Pooja</creatorcontrib><creatorcontrib>Balakrishnan, Neelima</creatorcontrib><creatorcontrib>Lomi, Neiwete</creatorcontrib><creatorcontrib>Gupta, Noopur</creatorcontrib><creatorcontrib>Vanathi, M.</creatorcontrib><creatorcontrib>Tandon, Radhika</creatorcontrib><title>Peripheral ulcerative keratitis</title><title>Survey of ophthalmology</title><addtitle>Surv Ophthalmol</addtitle><description>•A review on peripheral ulcerative keratitis (PUK) – its current diagnosis and management.•A systematic approach provided to the readers for workup of a case of PUK.•Emphasis on the rational and judicious use of immunosuppressants in PUK.
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Peripheral ulcerative keratitis (PUK) is an inflammatory condition of the peripheral cornea with hallmark features of epithelial defects and stromal destruction as a result of a complex interplay of factors including host autoimmunity and the peculiar anatomic and physiologic features of the peripheral cornea and environmental factors. PUK may be the result of local or systemic causes and infectious or noninfectious causes. Arriving at a specific etiological diagnosis requires a meticulous clinical workup that may include a battery of laboratory and radiological investigations. Management by a team of internists or rheumatologists and ophthalmologists and judicious use of immunosuppressive agents may yield favorable results minimizing adverse effects. We review current clinical knowledge on the diagnosis and management of PUK.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33657431</pmid><doi>10.1016/j.survophthal.2021.02.013</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0001-7365-5532</orcidid><orcidid>https://orcid.org/0000-0002-2479-797X</orcidid><orcidid>https://orcid.org/0000-0001-8022-6656</orcidid><orcidid>https://orcid.org/0000-0001-9554-9933</orcidid></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Autoimmunity Cornea Corneal Ulcer - diagnosis Corneal Ulcer - etiology Corneal Ulcer - therapy Humans Immunosuppressive Agents - therapeutic use Mooren ulcer Mooren's ulcer peripheral keratitis Peripheral ulcerative keratitis PUK |
| title | Peripheral ulcerative keratitis |
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