Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients
Mechanisms of impaired fatty acid metabolism may not be the same in nondialysis and hemodialysis patients. Correlations between the serum‐free carnitine concentration (FC), acylcarnitine concentration (AC), acyl to free carnitine ratio (AC/FC), and estimated glomerular filtration rate (eGFR) in the...
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| Veröffentlicht in: | Therapeutic apheresis and dialysis 2022-02, Vol.26 (1), p.122-129 |
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| container_title | Therapeutic apheresis and dialysis |
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| creator | Daimon, Shoichiro Yasuda, Miyuki Nishitani, Mitsuhiro |
| description | Mechanisms of impaired fatty acid metabolism may not be the same in nondialysis and hemodialysis patients. Correlations between the serum‐free carnitine concentration (FC), acylcarnitine concentration (AC), acyl to free carnitine ratio (AC/FC), and estimated glomerular filtration rate (eGFR) in the nondialysis population and the duration of hemodialysis in hemodialysis patients were investigated. As the eGFR decreased, the FC and AC increased, and as the duration of hemodialysis became longer, the FC and AC decreased. The AC/FC increased consistently as the eGFR decreased and the duration of hemodialysis increased. As an exception, the AC/FC decreased in the patients with a hemodialysis duration less than 90 days, which was not explained by carnitine removal by hemodialysis. In nondialysis patients, a functional, rather than an absolute, carnitine deficiency is a main cause of impaired fatty acid metabolism. Long‐term hemodialysis exacerbates absolute carnitine deficiency, whereas hemodialysis treatment may improve impaired fatty acid metabolism. |
| doi_str_mv | 10.1111/1744-9987.13638 |
| format | Article |
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Correlations between the serum‐free carnitine concentration (FC), acylcarnitine concentration (AC), acyl to free carnitine ratio (AC/FC), and estimated glomerular filtration rate (eGFR) in the nondialysis population and the duration of hemodialysis in hemodialysis patients were investigated. As the eGFR decreased, the FC and AC increased, and as the duration of hemodialysis became longer, the FC and AC decreased. The AC/FC increased consistently as the eGFR decreased and the duration of hemodialysis increased. As an exception, the AC/FC decreased in the patients with a hemodialysis duration less than 90 days, which was not explained by carnitine removal by hemodialysis. In nondialysis patients, a functional, rather than an absolute, carnitine deficiency is a main cause of impaired fatty acid metabolism. 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Correlations between the serum‐free carnitine concentration (FC), acylcarnitine concentration (AC), acyl to free carnitine ratio (AC/FC), and estimated glomerular filtration rate (eGFR) in the nondialysis population and the duration of hemodialysis in hemodialysis patients were investigated. As the eGFR decreased, the FC and AC increased, and as the duration of hemodialysis became longer, the FC and AC decreased. The AC/FC increased consistently as the eGFR decreased and the duration of hemodialysis increased. As an exception, the AC/FC decreased in the patients with a hemodialysis duration less than 90 days, which was not explained by carnitine removal by hemodialysis. In nondialysis patients, a functional, rather than an absolute, carnitine deficiency is a main cause of impaired fatty acid metabolism. Long‐term hemodialysis exacerbates absolute carnitine deficiency, whereas hemodialysis treatment may improve impaired fatty acid metabolism.</description><subject>acyl to free carnitine ratio</subject><subject>Aged</subject><subject>carnitine</subject><subject>Carnitine - analogs & derivatives</subject><subject>Carnitine - blood</subject><subject>chronic kidney disease</subject><subject>fatty acid</subject><subject>Female</subject><subject>hemodialysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Dialysis - methods</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>β‐oxidation</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwyAYgInRuDk9ezMcvXQrhdL2uCx-JUs0cZ4Jg7cZ2sKENqZXf7ndh403uUDI8z6QB6FrEk9Jv2YkYywqijybEsppfoLGw83pcM6KEboI4T2Ok4RReo5GlPKUZ3kxRt-v4NsaK-mtaYwFrJxVYBsvG-MsllbjZgNYqq7CjcOlB_gD7ylsLLbOaiOrLpiA1cY7axT-MNpCh7UJIAPsVRuo3cBt--H-pXCJzkpZBbg67hP0dn-3WjxGy-eHp8V8GSna_zVKc54lWupS5qRcl2mea80kZ6DVmgEnRLFSApNFkmSx5rqnUrqmknGqC11mdIJuD96td58thEbUJiioKmnBtUEkrOBJSnJW9OjsgCrvQvBQiq03tfSdILHYhRe7tGKXWezD9xM3R3m7rkEP_G_pHkgPwJepoPvPJ1bzl4P4B2gPkQs</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Daimon, Shoichiro</creator><creator>Yasuda, Miyuki</creator><creator>Nishitani, Mitsuhiro</creator><general>John Wiley & Sons Australia, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9399-7433</orcidid></search><sort><creationdate>202202</creationdate><title>Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients</title><author>Daimon, Shoichiro ; Yasuda, Miyuki ; Nishitani, Mitsuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3678-58672dadfa81fbf588dd4a64edcb4e611c4fae4a92270d6d81f53b3a463d9df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>acyl to free carnitine ratio</topic><topic>Aged</topic><topic>carnitine</topic><topic>Carnitine - analogs & derivatives</topic><topic>Carnitine - blood</topic><topic>chronic kidney disease</topic><topic>fatty acid</topic><topic>Female</topic><topic>hemodialysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Dialysis - methods</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>β‐oxidation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daimon, Shoichiro</creatorcontrib><creatorcontrib>Yasuda, Miyuki</creatorcontrib><creatorcontrib>Nishitani, Mitsuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daimon, Shoichiro</au><au>Yasuda, Miyuki</au><au>Nishitani, Mitsuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2022-02</date><risdate>2022</risdate><volume>26</volume><issue>1</issue><spage>122</spage><epage>129</epage><pages>122-129</pages><issn>1744-9979</issn><eissn>1744-9987</eissn><abstract>Mechanisms of impaired fatty acid metabolism may not be the same in nondialysis and hemodialysis patients. Correlations between the serum‐free carnitine concentration (FC), acylcarnitine concentration (AC), acyl to free carnitine ratio (AC/FC), and estimated glomerular filtration rate (eGFR) in the nondialysis population and the duration of hemodialysis in hemodialysis patients were investigated. As the eGFR decreased, the FC and AC increased, and as the duration of hemodialysis became longer, the FC and AC decreased. The AC/FC increased consistently as the eGFR decreased and the duration of hemodialysis increased. As an exception, the AC/FC decreased in the patients with a hemodialysis duration less than 90 days, which was not explained by carnitine removal by hemodialysis. In nondialysis patients, a functional, rather than an absolute, carnitine deficiency is a main cause of impaired fatty acid metabolism. 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| subjects | acyl to free carnitine ratio Aged carnitine Carnitine - analogs & derivatives Carnitine - blood chronic kidney disease fatty acid Female hemodialysis Humans Male Middle Aged Renal Dialysis - methods Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - therapy β‐oxidation |
| title | Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients |
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