Shaping Functional Avidity of CAR T Cells: Affinity, Avidity, and Antigen Density That Regulate Response

Chimeric antigen receptors (CARs) are immunoreceptors that redirect T cells to selectively kill tumor cells. Given their clinical successes in hematologic malignancies, there is a strong aspiration to advance this immunotherapy for solid cancers; hence, molecular CAR design and careful target choice...

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Veröffentlicht in:	Molecular cancer therapeutics 2021-05, Vol.20 (5), p.872-884
Hauptverfasser:	Greenman, Raanan, Pizem, Yoav, Haus-Cohen, Maya, Goor, Alona, Horev, Guy, Denkberg, Galit, Sinik, Keren, Elbaz, Yael, Bronner, Vered, Levin, Anat Globerson, Horn, Galit, Shen-Orr, Shai, Reiter, Yoram
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Cell Line, Tumor Female Humans Mice Receptors, Chimeric Antigen - immunology T-Lymphocytes - immunology
Online-Zugang:	Volltext
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