Study of the X‐ray radiation interaction with a multislit collimator for the creation of microbeams in radiation therapy

Microbeam radiation therapy (MRT) is a developing radiotherapy, based on the use of beams only a few tens of micrometres wide, generated by synchrotron X‐ray sources. The spatial fractionation of the homogeneous beam into an array of microbeams is possible using a multislit collimator (MSC), i.e. a...

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Veröffentlicht in:Journal of synchrotron radiation 2021-03, Vol.28 (2), p.392-403
Hauptverfasser: Pellicioli, P., Donzelli, M., Davis, J. A., Estève, F., Hugtenburg, R., Guatelli, S., Petasecca, M., Lerch, M. L. F., Bräuer-Krisch, E., Krisch, M.
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container_issue 2
container_start_page 392
container_title Journal of synchrotron radiation
container_volume 28
creator Pellicioli, P.
Donzelli, M.
Davis, J. A.
Estève, F.
Hugtenburg, R.
Guatelli, S.
Petasecca, M.
Lerch, M. L. F.
Bräuer-Krisch, E.
Krisch, M.
description Microbeam radiation therapy (MRT) is a developing radiotherapy, based on the use of beams only a few tens of micrometres wide, generated by synchrotron X‐ray sources. The spatial fractionation of the homogeneous beam into an array of microbeams is possible using a multislit collimator (MSC), i.e. a machined metal block with regular apertures. Dosimetry in MRT is challenging and previous works still show differences between calculated and experimental dose profiles of 10–30%, which are not acceptable for a clinical implementation of treatment. The interaction of the X‐rays with the MSC may contribute to the observed discrepancies; the present study therefore investigates the dose contribution due to radiation interaction with the MSC inner walls and radiation leakage of the MSC. Dose distributions inside a water‐equivalent phantom were evaluated for different field sizes and three typical spectra used for MRT studies at the European Synchrotron Biomedical beamline ID17. Film dosimetry was utilized to determine the contribution of radiation interaction with the MSC inner walls; Monte Carlo simulations were implemented to calculate the radiation leakage contribution. Both factors turned out to be relevant for the dose deposition, especially for small fields. Photons interacting with the MSC walls may bring up to 16% more dose in the valley regions, between the microbeams. Depending on the chosen spectrum, the radiation leakage close to the phantom surface can contribute up to 50% of the valley dose for a 5 mm × 5 mm field. The current study underlines that a detailed characterization of the MSC must be performed systematically and accurate MRT dosimetry protocols must include the contribution of radiation leakage and radiation interaction with the MSC in order to avoid significant errors in the dose evaluation at the micrometric scale. The study of the interaction of synchrotron X‐ray radiation with a multislit collimator is a critical factor for the creation of microbeams in radiation therapy. This study is a fundamental step forward in the understanding and definition of a reliable protocol for dosimetry at the micrometric scale to be used in microbeam radiation therapy.
doi_str_mv 10.1107/S1600577520016811
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The interaction of the X‐rays with the MSC may contribute to the observed discrepancies; the present study therefore investigates the dose contribution due to radiation interaction with the MSC inner walls and radiation leakage of the MSC. Dose distributions inside a water‐equivalent phantom were evaluated for different field sizes and three typical spectra used for MRT studies at the European Synchrotron Biomedical beamline ID17. Film dosimetry was utilized to determine the contribution of radiation interaction with the MSC inner walls; Monte Carlo simulations were implemented to calculate the radiation leakage contribution. Both factors turned out to be relevant for the dose deposition, especially for small fields. Photons interacting with the MSC walls may bring up to 16% more dose in the valley regions, between the microbeams. Depending on the chosen spectrum, the radiation leakage close to the phantom surface can contribute up to 50% of the valley dose for a 5 mm × 5 mm field. 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subjects Collimators
Dosimeters
Dosimetry
Fractionation
Leakage
Mathematical analysis
microbeam radiation therapy
Microbeams
Monte Carlo simulations
multislit collimators
Radiation dosage
Radiation therapy
synchrotron X‐ray radiation
Synchrotrons
Valleys
title Study of the X‐ray radiation interaction with a multislit collimator for the creation of microbeams in radiation therapy
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