Differential diagnosis of T2 hypointense masses in musculoskeletal MRI
Many soft tissue masses have an indeterminate appearance on MRI, often displaying varying degrees and extent of T2 hyperintensity. However, a subset of neoplasms and tumor-like lesions may exhibit prominent areas of T2 hypointensity relative to skeletal muscle. The hypointensity observed on T2-weigh...
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| Veröffentlicht in: | Skeletal radiology 2021-10, Vol.50 (10), p.1981-1994 |
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| container_end_page | 1994 |
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| container_issue | 10 |
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| container_title | Skeletal radiology |
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| creator | Finkelstein, Dara Foremny, Gregory Singer, Adam Clifford, Paul Pretell-Mazzini, Juan Kerr, Darcy A. Subhawong, Ty K. |
| description | Many soft tissue masses have an indeterminate appearance on MRI, often displaying varying degrees and extent of T2 hyperintensity. However, a subset of neoplasms and tumor-like lesions may exhibit prominent areas of T2 hypointensity relative to skeletal muscle. The hypointensity observed on T2-weighted MRI can be caused by a variety of substances, including evolving blood products, calcifications or other inorganic crystals, or fibrous tissue. Carefully evaluating the presence and pattern of T2 hypointensity in soft tissue masses and considering potential causes in their associated clinical contexts can help to narrow the differential diagnosis among neoplastic and non-neoplastic possibilities. These include endometriosis, aneurysmal bone cysts, tenosynovial giant cell tumor, arteriovenous malformation and pseudoaneurysm, calcium pyrophosphate and hydroxyapatite deposition diseases, tumoral calcinosis, gout, amyloidosis, hemangiomas with phleboliths, low-grade fibromyxoid sarcoma, ossifying fibromyxoid tumor, collagenous fibroma, desmoid-type fibromatosis, myxofibrosarcoma, peripheral nerve sheath tumors, dedifferentiated liposarcoma, and treated sarcoma. |
| doi_str_mv | 10.1007/s00256-021-03711-0 |
| format | Article |
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However, a subset of neoplasms and tumor-like lesions may exhibit prominent areas of T2 hypointensity relative to skeletal muscle. The hypointensity observed on T2-weighted MRI can be caused by a variety of substances, including evolving blood products, calcifications or other inorganic crystals, or fibrous tissue. Carefully evaluating the presence and pattern of T2 hypointensity in soft tissue masses and considering potential causes in their associated clinical contexts can help to narrow the differential diagnosis among neoplastic and non-neoplastic possibilities. These include endometriosis, aneurysmal bone cysts, tenosynovial giant cell tumor, arteriovenous malformation and pseudoaneurysm, calcium pyrophosphate and hydroxyapatite deposition diseases, tumoral calcinosis, gout, amyloidosis, hemangiomas with phleboliths, low-grade fibromyxoid sarcoma, ossifying fibromyxoid tumor, collagenous fibroma, desmoid-type fibromatosis, myxofibrosarcoma, peripheral nerve sheath tumors, dedifferentiated liposarcoma, and treated sarcoma.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-021-03711-0</identifier><identifier>PMID: 33651128</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amyloidosis ; Aneurysm ; Biological products ; Calcinosis ; Calcium ; Calcium phosphate ; Collagen ; Crystals ; Cysts ; Diagnosis ; Differential diagnosis ; Endometriosis ; Gout ; Hemangioma ; Hydroxyapatite ; Imaging ; Liposarcoma ; Magnetic resonance imaging ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Muscles ; Neoplasia ; Neoplasms ; Nuclear Medicine ; Orthopedics ; Pathology ; Peripheral nerves ; Pseudoaneurysm ; Radiology ; Review Article ; Sarcoma ; Sheaths ; Skeletal muscle ; Soft tissues ; Tumors</subject><ispartof>Skeletal radiology, 2021-10, Vol.50 (10), p.1981-1994</ispartof><rights>ISS 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>ISS 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-500c87f3f11a82b0ebd5bead4d5e1256f007305efd109ac6fc0d680dc79866033</citedby><cites>FETCH-LOGICAL-c442t-500c87f3f11a82b0ebd5bead4d5e1256f007305efd109ac6fc0d680dc79866033</cites><orcidid>0000-0003-0943-1168</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-021-03711-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-021-03711-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33651128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finkelstein, Dara</creatorcontrib><creatorcontrib>Foremny, Gregory</creatorcontrib><creatorcontrib>Singer, Adam</creatorcontrib><creatorcontrib>Clifford, Paul</creatorcontrib><creatorcontrib>Pretell-Mazzini, Juan</creatorcontrib><creatorcontrib>Kerr, Darcy A.</creatorcontrib><creatorcontrib>Subhawong, Ty K.</creatorcontrib><title>Differential diagnosis of T2 hypointense masses in musculoskeletal MRI</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Many soft tissue masses have an indeterminate appearance on MRI, often displaying varying degrees and extent of T2 hyperintensity. However, a subset of neoplasms and tumor-like lesions may exhibit prominent areas of T2 hypointensity relative to skeletal muscle. The hypointensity observed on T2-weighted MRI can be caused by a variety of substances, including evolving blood products, calcifications or other inorganic crystals, or fibrous tissue. Carefully evaluating the presence and pattern of T2 hypointensity in soft tissue masses and considering potential causes in their associated clinical contexts can help to narrow the differential diagnosis among neoplastic and non-neoplastic possibilities. These include endometriosis, aneurysmal bone cysts, tenosynovial giant cell tumor, arteriovenous malformation and pseudoaneurysm, calcium pyrophosphate and hydroxyapatite deposition diseases, tumoral calcinosis, gout, amyloidosis, hemangiomas with phleboliths, low-grade fibromyxoid sarcoma, ossifying fibromyxoid tumor, collagenous fibroma, desmoid-type fibromatosis, myxofibrosarcoma, peripheral nerve sheath tumors, dedifferentiated liposarcoma, and treated sarcoma.</description><subject>Amyloidosis</subject><subject>Aneurysm</subject><subject>Biological products</subject><subject>Calcinosis</subject><subject>Calcium</subject><subject>Calcium phosphate</subject><subject>Collagen</subject><subject>Crystals</subject><subject>Cysts</subject><subject>Diagnosis</subject><subject>Differential diagnosis</subject><subject>Endometriosis</subject><subject>Gout</subject><subject>Hemangioma</subject><subject>Hydroxyapatite</subject><subject>Imaging</subject><subject>Liposarcoma</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscles</subject><subject>Neoplasia</subject><subject>Neoplasms</subject><subject>Nuclear Medicine</subject><subject>Orthopedics</subject><subject>Pathology</subject><subject>Peripheral nerves</subject><subject>Pseudoaneurysm</subject><subject>Radiology</subject><subject>Review Article</subject><subject>Sarcoma</subject><subject>Sheaths</subject><subject>Skeletal muscle</subject><subject>Soft 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diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscles</topic><topic>Neoplasia</topic><topic>Neoplasms</topic><topic>Nuclear Medicine</topic><topic>Orthopedics</topic><topic>Pathology</topic><topic>Peripheral nerves</topic><topic>Pseudoaneurysm</topic><topic>Radiology</topic><topic>Review Article</topic><topic>Sarcoma</topic><topic>Sheaths</topic><topic>Skeletal muscle</topic><topic>Soft tissues</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finkelstein, Dara</creatorcontrib><creatorcontrib>Foremny, Gregory</creatorcontrib><creatorcontrib>Singer, Adam</creatorcontrib><creatorcontrib>Clifford, Paul</creatorcontrib><creatorcontrib>Pretell-Mazzini, Juan</creatorcontrib><creatorcontrib>Kerr, Darcy A.</creatorcontrib><creatorcontrib>Subhawong, Ty K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Radiol</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>50</volume><issue>10</issue><spage>1981</spage><epage>1994</epage><pages>1981-1994</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Many soft tissue masses have an indeterminate appearance on MRI, often displaying varying degrees and extent of T2 hyperintensity. However, a subset of neoplasms and tumor-like lesions may exhibit prominent areas of T2 hypointensity relative to skeletal muscle. The hypointensity observed on T2-weighted MRI can be caused by a variety of substances, including evolving blood products, calcifications or other inorganic crystals, or fibrous tissue. Carefully evaluating the presence and pattern of T2 hypointensity in soft tissue masses and considering potential causes in their associated clinical contexts can help to narrow the differential diagnosis among neoplastic and non-neoplastic possibilities. These include endometriosis, aneurysmal bone cysts, tenosynovial giant cell tumor, arteriovenous malformation and pseudoaneurysm, calcium pyrophosphate and hydroxyapatite deposition diseases, tumoral calcinosis, gout, amyloidosis, hemangiomas with phleboliths, low-grade fibromyxoid sarcoma, ossifying fibromyxoid tumor, collagenous fibroma, desmoid-type fibromatosis, myxofibrosarcoma, peripheral nerve sheath tumors, dedifferentiated liposarcoma, and treated sarcoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33651128</pmid><doi>10.1007/s00256-021-03711-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0943-1168</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Amyloidosis Aneurysm Biological products Calcinosis Calcium Calcium phosphate Collagen Crystals Cysts Diagnosis Differential diagnosis Endometriosis Gout Hemangioma Hydroxyapatite Imaging Liposarcoma Magnetic resonance imaging Medical diagnosis Medicine Medicine & Public Health Muscles Neoplasia Neoplasms Nuclear Medicine Orthopedics Pathology Peripheral nerves Pseudoaneurysm Radiology Review Article Sarcoma Sheaths Skeletal muscle Soft tissues Tumors |
| title | Differential diagnosis of T2 hypointense masses in musculoskeletal MRI |
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