The thioamidation of gem-dibromoalkenes in an aqueous medium
The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. The presented green protocol emphasizes the suitability of aqueous media for the thioamidation reaction and enables greater selectivity with synthetic utility. A...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2021-03, Vol.19 (11), p.2473-2480 |
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| container_issue | 11 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Vankar, Jigarkumar K Gupta, Ankush Jadav, Jaydeepbhai P Nanjegowda, Shankara H Gururaja, Guddeangadi N |
| description | The direct integration of sulphur and amine groups with 1,1-dibromoalkenes for thioamide synthesis has been achieved in an aqueous medium. The presented green protocol emphasizes the suitability of aqueous media for the thioamidation reaction and enables greater selectivity with synthetic utility. A wide range of thioamides in moderate to excellent yields has been achieved using readily available starting materials, with the use of no organic solvents, catalysts, or additives. |
| doi_str_mv | 10.1039/d0ob02319a |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2021-03, Vol.19 (11), p.2473-2480 |
| issn | 1477-0520 1477-0539 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Additives Aqueous solutions Catalysts Crystallography Organic solvents Selectivity Sulfur |
| title | The thioamidation of gem-dibromoalkenes in an aqueous medium |
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