Ex vivo glucocorticoid‐induced secreted proteome approach for discovery of glucocorticoid‐responsive proteins in human serum

Purpose To identify glucocorticoid‐responsive proteins measurable in human serum that may have clinical utility in therapeutic drug monitoring and the diagnosis of cortisol excess or deficiency. Experimental Design A phased biomarker discovery strategy was conducted in two cohorts. Secretome from pe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proteomics (Weinheim) 2021-05, Vol.15 (2-3), p.e2000078-n/a
Hauptverfasser:	Inder, Warrick J., Mohamed, Ahmed, Keshvari, Sahar, Barclay, Johanna L., Ruelcke, Jayde E., Stoll, Thomas, Nolan, Brendan J., Cesana‐Nigro, Nicole, Hill, Michelle M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult biomarker Biomarkers Biomarkers - blood Biomarkers - metabolism Blood Proteins - metabolism Cortisol Design of experiments Dexamethasone Dexamethasone - pharmacology Drug development Experimental design Female glucocorticoid proteomics Glucocorticoids Glucocorticoids - pharmacology Humans Immunoassay Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lysozyme Male Mass spectrometry Mass spectroscopy Middle Aged Monitoring PBMC Peripheral blood mononuclear cells Proteins Proteome - metabolism Proteomes Proteomics Secretome Serum proteins Therapeutic drug monitoring
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!