Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas
Solute carrier family 16 member 1 (SLC16A1) is a crucial transcription factor in modifying cancer progression and metastasis. However, its character in defining the clinical prognosis of human gliomas has not been illuminated. In our analysis from PREdiction of Clinical Outcomes from Genomic Profile...
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| Veröffentlicht in: | Journal of molecular neuroscience 2021-08, Vol.71 (8), p.1614-1621 |
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| creator | Lin, Hong-Han Tsai, Wen-Chiuan Tsai, Chia-Kuang Chen, Ssu-Han Huang, Li-Chun Hueng, Dueng-Yuan Hung, Kuang-Chen |
| description | Solute carrier family 16 member 1 (SLC16A1) is a crucial transcription factor in modifying cancer progression and metastasis. However, its character in defining the clinical prognosis of human gliomas has not been illuminated. In our analysis from PREdiction of Clinical Outcomes from Genomic Profiles (PRECOG), The Cancer Genome Atlas (TCGA), and Chinese Glioma Genome Atlas (CGGA), we found that
SLC16A1
mRNA expression level was significantly increased in high-grade gliomas in contrast to low-grade gliomas and non-tumor controls (
P
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| doi_str_mv | 10.1007/s12031-021-01806-w |
| format | Article |
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SLC16A1
mRNA expression level was significantly increased in high-grade gliomas in contrast to low-grade gliomas and non-tumor controls (
P
< 0.05). Kaplan–Meier analysis of four independent cohort studies from the Gene Expression Omnibus (GEO) profile, TCGA, and CGGA which consistently presented patients with high
SLC16A1
mRNA expression displayed poor overall survival in high-grade glioma patients (
P
< 0.05 by log-rank test). Based on the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), the protein–protein interaction analysis of SLC16A1-regulated oncogenesis showed SLC16A1 as a potential hub protein. Immunohistochemical staining exhibited that SLC16A1 protein overexpressed in high-grade gliomas compared with low-grade clinical glioma samples. All these findings suggest that
SLC16A1
expression has a positive correlation with WHO pathological grading and poor survival. SLC16A1 might be a potential biomarker of prognosis in human gliomas.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-021-01806-w</identifier><identifier>PMID: 33641091</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cancer ; Cell Biology ; Cell Line, Tumor ; Cell surface ; Gene expression ; Genomes ; Glioma ; Glioma - genetics ; Glioma - metabolism ; Glioma - pathology ; Humans ; Medical prognosis ; Metastases ; Monocarboxylic Acid Transporters - genetics ; Monocarboxylic Acid Transporters - metabolism ; Neurochemistry ; Neurology ; Neurosciences ; Patients ; Prognosis ; Protein Interaction Maps ; Proteins ; Proteomics ; Rank tests ; Surface markers ; Survival ; Survival Analysis ; Symporters - genetics ; Symporters - metabolism ; Tumorigenesis</subject><ispartof>Journal of molecular neuroscience, 2021-08, Vol.71 (8), p.1614-1621</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c1b72c0b6fadd243a573ca30ae27cfd54586b21f61d31ec0753125484cb71e6d3</citedby><cites>FETCH-LOGICAL-c375t-c1b72c0b6fadd243a573ca30ae27cfd54586b21f61d31ec0753125484cb71e6d3</cites><orcidid>0000-0001-7868-3161</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-021-01806-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-021-01806-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33641091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Hong-Han</creatorcontrib><creatorcontrib>Tsai, Wen-Chiuan</creatorcontrib><creatorcontrib>Tsai, Chia-Kuang</creatorcontrib><creatorcontrib>Chen, Ssu-Han</creatorcontrib><creatorcontrib>Huang, Li-Chun</creatorcontrib><creatorcontrib>Hueng, Dueng-Yuan</creatorcontrib><creatorcontrib>Hung, Kuang-Chen</creatorcontrib><title>Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Solute carrier family 16 member 1 (SLC16A1) is a crucial transcription factor in modifying cancer progression and metastasis. However, its character in defining the clinical prognosis of human gliomas has not been illuminated. In our analysis from PREdiction of Clinical Outcomes from Genomic Profiles (PRECOG), The Cancer Genome Atlas (TCGA), and Chinese Glioma Genome Atlas (CGGA), we found that
SLC16A1
mRNA expression level was significantly increased in high-grade gliomas in contrast to low-grade gliomas and non-tumor controls (
P
< 0.05). Kaplan–Meier analysis of four independent cohort studies from the Gene Expression Omnibus (GEO) profile, TCGA, and CGGA which consistently presented patients with high
SLC16A1
mRNA expression displayed poor overall survival in high-grade glioma patients (
P
< 0.05 by log-rank test). Based on the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), the protein–protein interaction analysis of SLC16A1-regulated oncogenesis showed SLC16A1 as a potential hub protein. Immunohistochemical staining exhibited that SLC16A1 protein overexpressed in high-grade gliomas compared with low-grade clinical glioma samples. All these findings suggest that
SLC16A1
expression has a positive correlation with WHO pathological grading and poor survival. SLC16A1 might be a potential biomarker of prognosis in human gliomas.</description><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell surface</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Monocarboxylic Acid Transporters - genetics</subject><subject>Monocarboxylic Acid Transporters - metabolism</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Protein Interaction Maps</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Rank tests</subject><subject>Surface markers</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Symporters - genetics</subject><subject>Symporters - metabolism</subject><subject>Tumorigenesis</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kD1vFDEQhi0UlByBP5ACWUpDY_D4e8voBBekQymOdJEsr3c22WQ_Dvv2Av8ewyUgUVB4XPiZdzwPIWfA3wPn9kMGwSUwLsoBxw17fEEWoHXFAIw5IgvuKs2cqcwJeZXzPS-kAndMTqQ0CngFC3JztceE37cJc-6mkU4tXWLfs82c2hCRfgnpARPdrJdgLoBu7qa0wxEbWoB9tw897UZ6OQ-h1O72jq1SaJCu-m4aQn5NXrahz_jm6T4l158-fl1esvXV6vPyYs2itHrHItRWRF6bNjSNUDJoK2OQPKCwsW200s7UAloDjQSM3GoJQiunYm0BTSNPybtD7jZN32bMOz90OZY1wojTnL1QlXJOOWsLev4Pej_NaSy_86KYAwOV1oUSByqmKeeErd-mbgjphwfuf7n3B_e-GPW_3fvH0vT2KXquB2z-tDzLLoA8ALk8jbeY_s7-T-xPSweNzg</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Lin, Hong-Han</creator><creator>Tsai, Wen-Chiuan</creator><creator>Tsai, Chia-Kuang</creator><creator>Chen, Ssu-Han</creator><creator>Huang, Li-Chun</creator><creator>Hueng, Dueng-Yuan</creator><creator>Hung, Kuang-Chen</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7868-3161</orcidid></search><sort><creationdate>20210801</creationdate><title>Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas</title><author>Lin, Hong-Han ; Tsai, Wen-Chiuan ; Tsai, Chia-Kuang ; Chen, Ssu-Han ; Huang, Li-Chun ; Hueng, Dueng-Yuan ; Hung, Kuang-Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c1b72c0b6fadd243a573ca30ae27cfd54586b21f61d31ec0753125484cb71e6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell Line, Tumor</topic><topic>Cell surface</topic><topic>Gene expression</topic><topic>Genomes</topic><topic>Glioma</topic><topic>Glioma - genetics</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Monocarboxylic Acid Transporters - genetics</topic><topic>Monocarboxylic Acid Transporters - metabolism</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Protein Interaction Maps</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Rank tests</topic><topic>Surface markers</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Symporters - genetics</topic><topic>Symporters - metabolism</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Hong-Han</creatorcontrib><creatorcontrib>Tsai, Wen-Chiuan</creatorcontrib><creatorcontrib>Tsai, Chia-Kuang</creatorcontrib><creatorcontrib>Chen, Ssu-Han</creatorcontrib><creatorcontrib>Huang, Li-Chun</creatorcontrib><creatorcontrib>Hueng, Dueng-Yuan</creatorcontrib><creatorcontrib>Hung, Kuang-Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Hong-Han</au><au>Tsai, Wen-Chiuan</au><au>Tsai, Chia-Kuang</au><au>Chen, Ssu-Han</au><au>Huang, Li-Chun</au><au>Hueng, Dueng-Yuan</au><au>Hung, Kuang-Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas</atitle><jtitle>Journal of molecular neuroscience</jtitle><stitle>J Mol Neurosci</stitle><addtitle>J Mol Neurosci</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>71</volume><issue>8</issue><spage>1614</spage><epage>1621</epage><pages>1614-1621</pages><issn>0895-8696</issn><eissn>1559-1166</eissn><abstract>Solute carrier family 16 member 1 (SLC16A1) is a crucial transcription factor in modifying cancer progression and metastasis. However, its character in defining the clinical prognosis of human gliomas has not been illuminated. In our analysis from PREdiction of Clinical Outcomes from Genomic Profiles (PRECOG), The Cancer Genome Atlas (TCGA), and Chinese Glioma Genome Atlas (CGGA), we found that
SLC16A1
mRNA expression level was significantly increased in high-grade gliomas in contrast to low-grade gliomas and non-tumor controls (
P
< 0.05). Kaplan–Meier analysis of four independent cohort studies from the Gene Expression Omnibus (GEO) profile, TCGA, and CGGA which consistently presented patients with high
SLC16A1
mRNA expression displayed poor overall survival in high-grade glioma patients (
P
< 0.05 by log-rank test). Based on the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), the protein–protein interaction analysis of SLC16A1-regulated oncogenesis showed SLC16A1 as a potential hub protein. Immunohistochemical staining exhibited that SLC16A1 protein overexpressed in high-grade gliomas compared with low-grade clinical glioma samples. All these findings suggest that
SLC16A1
expression has a positive correlation with WHO pathological grading and poor survival. SLC16A1 might be a potential biomarker of prognosis in human gliomas.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33641091</pmid><doi>10.1007/s12031-021-01806-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7868-3161</orcidid></addata></record> |
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| subjects | Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Cell Biology Cell Line, Tumor Cell surface Gene expression Genomes Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Humans Medical prognosis Metastases Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Neurochemistry Neurology Neurosciences Patients Prognosis Protein Interaction Maps Proteins Proteomics Rank tests Surface markers Survival Survival Analysis Symporters - genetics Symporters - metabolism Tumorigenesis |
| title | Overexpression of Cell-Surface Marker SLC16A1 Shortened Survival in Human High-Grade Gliomas |
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