Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles

[Display omitted] Lipid nanoparticles (LNPs) are increasingly employed to improve delivery efficiency and therapeutic efficacy of nucleic acids. Various formulation parameters can affect the quality attributes of these nanoparticle formulations, but currently there is a lack of systemic screening ap...

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Veröffentlicht in:	International journal of pharmaceutics 2021-04, Vol.599, p.120392-120392, Article 120392
Hauptverfasser:	Fan, Yuchen, Yen, Chun-Wan, Lin, Hsiu-Chao, Hou, Weijia, Estevez, Alberto, Sarode, Apoorva, Goyon, Alexandre, Bian, Juan, Lin, Jessica, Koenig, Stefan G., Leung, Dennis, Nagapudi, Karthik, Zhang, Kelly
Format:	Artikel
Sprache:	eng
Schlagworte:	Automation High-throughput screening Lipid nanoparticle Oligonucleotide Quality attributes
Online-Zugang:	Volltext
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