Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen

Outside-in integrin signaling regulates cell fate decisions in a variety of cell types, including hematopoietic stem cells (HSCs). Our earlier published studies showed that interruption of periostin (POSTN) and integrin-av (ITGAV) interaction induces faster proliferation in HSCs with developmental s...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-04, Vol.206 (7), p.1549-1560
Hauptverfasser:	Mehatre, Shubham Haribhau, Roy, Irene Mariam, Biswas, Atreyi, Prit, Devila, Schouteden, Sarah, Huelsken, Joerg, Verfaillie, Catherine M., Khurana, Satish
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Proliferation Gene Knockdown Techniques Hematopoiesis Hematopoietic Stem Cells - physiology Immunology Integrin alpha5 - genetics Integrin alpha5 - metabolism Life Sciences & Biomedicine Lymphocytes - physiology Mice Mice, Knockout Myocytes, Smooth Muscle - physiology Myofibroblasts - physiology Science & Technology Signal Transduction Spleen - immunology Stem Cell Niche
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