Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model
Background Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions. Objecti...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 2021-08, Vol.48 (8), p.1090-1102 |
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| creator | Wang, Zitong Baharani, Akanksha Wei, Zelan Truong, Davin Bi, Xiaoying Wang, Fei Li, Xin‐Min Verge, Valerie M. K. Zhang, Yanbo |
| description | Background
Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.
Objective
This study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non‐invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.
Methods
C57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.
Results
Improved cognition and depression‐like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione‐S‐transferase (GST‐π). In addition, expression of TGF‐β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.
Conclusion
Results from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.
Low field magnetic stimulation (LFMS) is a non‐invasive brain stimulation device that improved cognition and depression‐like behaviour and promoted myelin repair and oligodendrocyte maturation in a chronic cuprizone intoxication animal model. The transforming growth factor‐beta signaling pathway may be activated due to LFMS. This study suggests that LFMS has therapeutic potential in demyelinating diseases and related cognitive impairment and depression. |
| doi_str_mv | 10.1111/1440-1681.13490 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2494304232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2547130617</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4370-307888be274fe7952586ed121c5a5fce620001db38a8857240472551ad8796f13</originalsourceid><addsrcrecordid>eNqFkc1PGzEQxa0KVALtmRuyxKWXJf5cO8cqooAUqRzgbDneWWq0tlN7FxT--jok5dBLfRhLo988vXmD0DklV7S-ORWCNLTV9IpysSCf0Oyjc4RmhBPZUK3ICTot5ZkQIknLP6MTzluuGRczFFbpFfcehg4H-xRh9A6X0YdpsKNPEW9yCmmEgsMWBh9xho31GdvYYZeeoh_9C9SmSy-Qt7gC7ldOsYq4aZP9W4qAQ5rKrnYwfEHHvR0KfD38Z-jxx_XD8rZZ_by5W35fNU5wRRpOlNZ6DUyJHtRCMqlb6CijTlrZO2hZXYV2a66t1lIxQYRiUlLbabVoe8rP0Le9brX_e4IymuCLg2GwEaobw8RCcCIYZxW9_Ad9TlOO1Z1hUijKSUtVpeZ7yuVUSobe1O2CzVtDidldwuxyN7vczfsl6sTFQXdaB-g--L_RV0DugVc_wPZ_emZ5fb8X_gPHYJIF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547130617</pqid></control><display><type>article</type><title>Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Wang, Zitong ; Baharani, Akanksha ; Wei, Zelan ; Truong, Davin ; Bi, Xiaoying ; Wang, Fei ; Li, Xin‐Min ; Verge, Valerie M. K. ; Zhang, Yanbo</creator><creatorcontrib>Wang, Zitong ; Baharani, Akanksha ; Wei, Zelan ; Truong, Davin ; Bi, Xiaoying ; Wang, Fei ; Li, Xin‐Min ; Verge, Valerie M. K. ; Zhang, Yanbo</creatorcontrib><description>Background
Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.
Objective
This study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non‐invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.
Methods
C57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.
Results
Improved cognition and depression‐like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione‐S‐transferase (GST‐π). In addition, expression of TGF‐β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.
Conclusion
Results from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.
Low field magnetic stimulation (LFMS) is a non‐invasive brain stimulation device that improved cognition and depression‐like behaviour and promoted myelin repair and oligodendrocyte maturation in a chronic cuprizone intoxication animal model. The transforming growth factor‐beta signaling pathway may be activated due to LFMS. This study suggests that LFMS has therapeutic potential in demyelinating diseases and related cognitive impairment and depression.</description><identifier>ISSN: 0305-1870</identifier><identifier>ISSN: 1440-1681</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/1440-1681.13490</identifier><identifier>PMID: 33638234</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biomarkers ; Body weight gain ; Cognition ; Cognitive ability ; Cognitive Dysfunction - chemically induced ; Cognitive Dysfunction - metabolism ; Cognitive Dysfunction - therapy ; Cuprizone ; Demyelinating diseases ; Demyelinating Diseases - chemically induced ; Demyelinating Diseases - metabolism ; Demyelinating Diseases - therapy ; Demyelination ; Disease Models, Animal ; Female ; Glutathione ; Glycoproteins ; Immunoblotting ; Impairment ; LFMS ; Magnetic Field Therapy - methods ; Magnetic fields ; Mental depression ; Mice ; Mice, Inbred C57BL ; Multiple sclerosis ; Multiple Sclerosis - chemically induced ; Multiple Sclerosis - metabolism ; Multiple Sclerosis - therapy ; Myelin ; Myelin basic protein ; Myelin Sheath - metabolism ; Neuromodulation ; Neuroprotection ; Oligodendrocyte-myelin glycoprotein ; Oligodendrocytes ; Prefrontal cortex ; Proteins ; Recovery of Function ; remyelination ; Repair ; Signs and symptoms ; Stimulation</subject><ispartof>Clinical and experimental pharmacology & physiology, 2021-08, Vol.48 (8), p.1090-1102</ispartof><rights>2021 John Wiley & Sons Australia, Ltd</rights><rights>2021 John Wiley & Sons Australia, Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4370-307888be274fe7952586ed121c5a5fce620001db38a8857240472551ad8796f13</citedby><cites>FETCH-LOGICAL-c4370-307888be274fe7952586ed121c5a5fce620001db38a8857240472551ad8796f13</cites><orcidid>0000-0002-2421-157X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1440-1681.13490$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1440-1681.13490$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33638234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zitong</creatorcontrib><creatorcontrib>Baharani, Akanksha</creatorcontrib><creatorcontrib>Wei, Zelan</creatorcontrib><creatorcontrib>Truong, Davin</creatorcontrib><creatorcontrib>Bi, Xiaoying</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Li, Xin‐Min</creatorcontrib><creatorcontrib>Verge, Valerie M. K.</creatorcontrib><creatorcontrib>Zhang, Yanbo</creatorcontrib><title>Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>Background
Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.
Objective
This study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non‐invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.
Methods
C57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.
Results
Improved cognition and depression‐like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione‐S‐transferase (GST‐π). In addition, expression of TGF‐β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.
Conclusion
Results from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.
Low field magnetic stimulation (LFMS) is a non‐invasive brain stimulation device that improved cognition and depression‐like behaviour and promoted myelin repair and oligodendrocyte maturation in a chronic cuprizone intoxication animal model. The transforming growth factor‐beta signaling pathway may be activated due to LFMS. This study suggests that LFMS has therapeutic potential in demyelinating diseases and related cognitive impairment and depression.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Body weight gain</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - chemically induced</subject><subject>Cognitive Dysfunction - metabolism</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Cuprizone</subject><subject>Demyelinating diseases</subject><subject>Demyelinating Diseases - chemically induced</subject><subject>Demyelinating Diseases - metabolism</subject><subject>Demyelinating Diseases - therapy</subject><subject>Demyelination</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glycoproteins</subject><subject>Immunoblotting</subject><subject>Impairment</subject><subject>LFMS</subject><subject>Magnetic Field Therapy - methods</subject><subject>Magnetic fields</subject><subject>Mental depression</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - chemically induced</subject><subject>Multiple Sclerosis - metabolism</subject><subject>Multiple Sclerosis - therapy</subject><subject>Myelin</subject><subject>Myelin basic protein</subject><subject>Myelin Sheath - metabolism</subject><subject>Neuromodulation</subject><subject>Neuroprotection</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Oligodendrocytes</subject><subject>Prefrontal cortex</subject><subject>Proteins</subject><subject>Recovery of Function</subject><subject>remyelination</subject><subject>Repair</subject><subject>Signs and symptoms</subject><subject>Stimulation</subject><issn>0305-1870</issn><issn>1440-1681</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1PGzEQxa0KVALtmRuyxKWXJf5cO8cqooAUqRzgbDneWWq0tlN7FxT--jok5dBLfRhLo988vXmD0DklV7S-ORWCNLTV9IpysSCf0Oyjc4RmhBPZUK3ICTot5ZkQIknLP6MTzluuGRczFFbpFfcehg4H-xRh9A6X0YdpsKNPEW9yCmmEgsMWBh9xho31GdvYYZeeoh_9C9SmSy-Qt7gC7ldOsYq4aZP9W4qAQ5rKrnYwfEHHvR0KfD38Z-jxx_XD8rZZ_by5W35fNU5wRRpOlNZ6DUyJHtRCMqlb6CijTlrZO2hZXYV2a66t1lIxQYRiUlLbabVoe8rP0Le9brX_e4IymuCLg2GwEaobw8RCcCIYZxW9_Ad9TlOO1Z1hUijKSUtVpeZ7yuVUSobe1O2CzVtDidldwuxyN7vczfsl6sTFQXdaB-g--L_RV0DugVc_wPZ_emZ5fb8X_gPHYJIF</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Wang, Zitong</creator><creator>Baharani, Akanksha</creator><creator>Wei, Zelan</creator><creator>Truong, Davin</creator><creator>Bi, Xiaoying</creator><creator>Wang, Fei</creator><creator>Li, Xin‐Min</creator><creator>Verge, Valerie M. K.</creator><creator>Zhang, Yanbo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2421-157X</orcidid></search><sort><creationdate>202108</creationdate><title>Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model</title><author>Wang, Zitong ; Baharani, Akanksha ; Wei, Zelan ; Truong, Davin ; Bi, Xiaoying ; Wang, Fei ; Li, Xin‐Min ; Verge, Valerie M. K. ; Zhang, Yanbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4370-307888be274fe7952586ed121c5a5fce620001db38a8857240472551ad8796f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Body weight gain</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - chemically induced</topic><topic>Cognitive Dysfunction - metabolism</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Cuprizone</topic><topic>Demyelinating diseases</topic><topic>Demyelinating Diseases - chemically induced</topic><topic>Demyelinating Diseases - metabolism</topic><topic>Demyelinating Diseases - therapy</topic><topic>Demyelination</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glycoproteins</topic><topic>Immunoblotting</topic><topic>Impairment</topic><topic>LFMS</topic><topic>Magnetic Field Therapy - methods</topic><topic>Magnetic fields</topic><topic>Mental depression</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - chemically induced</topic><topic>Multiple Sclerosis - metabolism</topic><topic>Multiple Sclerosis - therapy</topic><topic>Myelin</topic><topic>Myelin basic protein</topic><topic>Myelin Sheath - metabolism</topic><topic>Neuromodulation</topic><topic>Neuroprotection</topic><topic>Oligodendrocyte-myelin glycoprotein</topic><topic>Oligodendrocytes</topic><topic>Prefrontal cortex</topic><topic>Proteins</topic><topic>Recovery of Function</topic><topic>remyelination</topic><topic>Repair</topic><topic>Signs and symptoms</topic><topic>Stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zitong</creatorcontrib><creatorcontrib>Baharani, Akanksha</creatorcontrib><creatorcontrib>Wei, Zelan</creatorcontrib><creatorcontrib>Truong, Davin</creatorcontrib><creatorcontrib>Bi, Xiaoying</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Li, Xin‐Min</creatorcontrib><creatorcontrib>Verge, Valerie M. K.</creatorcontrib><creatorcontrib>Zhang, Yanbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zitong</au><au>Baharani, Akanksha</au><au>Wei, Zelan</au><au>Truong, Davin</au><au>Bi, Xiaoying</au><au>Wang, Fei</au><au>Li, Xin‐Min</au><au>Verge, Valerie M. K.</au><au>Zhang, Yanbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>48</volume><issue>8</issue><spage>1090</spage><epage>1102</epage><pages>1090-1102</pages><issn>0305-1870</issn><issn>1440-1681</issn><eissn>1440-1681</eissn><abstract>Background
Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.
Objective
This study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non‐invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.
Methods
C57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.
Results
Improved cognition and depression‐like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione‐S‐transferase (GST‐π). In addition, expression of TGF‐β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.
Conclusion
Results from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.
Low field magnetic stimulation (LFMS) is a non‐invasive brain stimulation device that improved cognition and depression‐like behaviour and promoted myelin repair and oligodendrocyte maturation in a chronic cuprizone intoxication animal model. The transforming growth factor‐beta signaling pathway may be activated due to LFMS. This study suggests that LFMS has therapeutic potential in demyelinating diseases and related cognitive impairment and depression.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33638234</pmid><doi>10.1111/1440-1681.13490</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-2421-157X</orcidid></addata></record> |
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| subjects | Animals Biomarkers Body weight gain Cognition Cognitive ability Cognitive Dysfunction - chemically induced Cognitive Dysfunction - metabolism Cognitive Dysfunction - therapy Cuprizone Demyelinating diseases Demyelinating Diseases - chemically induced Demyelinating Diseases - metabolism Demyelinating Diseases - therapy Demyelination Disease Models, Animal Female Glutathione Glycoproteins Immunoblotting Impairment LFMS Magnetic Field Therapy - methods Magnetic fields Mental depression Mice Mice, Inbred C57BL Multiple sclerosis Multiple Sclerosis - chemically induced Multiple Sclerosis - metabolism Multiple Sclerosis - therapy Myelin Myelin basic protein Myelin Sheath - metabolism Neuromodulation Neuroprotection Oligodendrocyte-myelin glycoprotein Oligodendrocytes Prefrontal cortex Proteins Recovery of Function remyelination Repair Signs and symptoms Stimulation |
| title | Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model |
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