Continuous capture scale down model: A comparison of a continuous and a discrete approach

In continuous pharmaceutical manufacturing, consisting of a perfused batch fermentation and integrated continuous downstream processing, the continuous capture is the linking unit operation. For the development of this unit operation, scale‐down models (SDMs) are crucial, whereas discrete, noncontin...

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Veröffentlicht in:	Biotechnology and bioengineering 2021-09, Vol.118 (9), p.3375-3381
Hauptverfasser:	Seidel, Jonathan C., Göbel, Mathias, Dos Reis Rodrigues, Rui C., Kaup, Nora M., Rapp, Johanna, Frauenschuh, Achim, Shultz, Joseph, Cui, Huanchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - isolation & purification CHO Cells continuous capture continuous manufacturing Cricetulus Fermentation Models, Theoretical Protein A protein A chromatography Protein purification scale‐down model Technology, Pharmaceutical
Online-Zugang:	Volltext
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