The nuclear retinoid‐related orphan receptor RORα controls adipose tissue inflammation in patients with morbid obesity and diabetes

Background/aims Inflammation governs adipose tissue (AT) dysfunction in obesity. Retinoic acid receptor-related orphan receptor alpha (RORα) is associated with inflammation and insulin resistance in animal studies, but its role in human obesity remains elusive. We investigated the expression and fun...

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Veröffentlicht in:	International Journal of Obesity 2021-07, Vol.45 (7), p.1369-1381
Hauptverfasser:	Ortega, Rebeca, Hueso, Luisa, Benito, Esther, Ortega, Joaquín, Civera, Miguel, Sanz, Maria-Jesus, Real, José T., Piqueras, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/51 38/77 692/163/2743/393 692/699/75 82/80 96/106 Adipose tissue Adipose Tissue - cytology Adipose Tissue - metabolism Adult AKT protein Body fat Body mass index Body size Cell adhesion Chemokines Cohort Studies Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Endothelial cells Epidemiology Explants Female Health Promotion and Disease Prevention Homeostasis Humans Inflammation Inflammation - metabolism Insulin Insulin resistance Interleukin 8 Internal Medicine Kinases Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Monocyte chemoattractant protein 1 NF-κB protein Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism Obesity Obesity, Morbid - complications Obesity, Morbid - metabolism Public Health Receptors Retinoic acid Surgery Tissue Culture Techniques
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