Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes

The ability to regulate membrane protein abundance offers great opportunities for developing therapeutic sites for various diseases. Herein, we describe a platform for the targeted degradation of membrane‐associated proteins using bispecific aptamer chimeras that bind both the cell‐surface lysosome‐...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-05, Vol.60 (20), p.11267-11271
Hauptverfasser:	Miao, Yanyan, Gao, Qianqian, Mao, Menghan, Zhang, Chao, Yang, Liqun, Yang, Yang, Han, Da
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers Biodegradation Cell membranes Cell surface Chimeras Degradation Lysosomal protein Lysosomes Membrane proteins membrane-associated proteins Membranes protein degradation Protein-tyrosine kinase Proteins receptors therapeutic strategies
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