Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study
Purpose Pentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intens...
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| Veröffentlicht in: | European journal of applied physiology 2021-06, Vol.121 (6), p.1567-1577 |
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| container_title | European journal of applied physiology |
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| creator | Slusher, Aaron L. Fico, Brandon G. Dodge, Katelyn M. Garten, Ryan S. Ferrandi, Peter J. Rodriguez, Alexandra A. Pena, Gabriel Huang, Chun-Jung |
| description | Purpose
Pentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intensity interval exercise (HIIE) has been demonstrated to be as effective as continuous moderate-intensity exercise in improving endothelial function, as indicated by brachial artery flow-mediated dilation (BAFMD), in patients with CVD. Therefore, the purpose of this study was to examine the effect of acute HIIE on plasma PTX3 and BAFMD responses in obese individuals.
Methods
Eight obese and six normal-weight young males participated in acute HIIE (4 intervals of 4 min at 80–90% of VO
2max
; 3 min of active recovery at 50–60% VO
2max
). Plasma PTX3 and BAFMD were measured prior to, immediately following exercise, and one and 2 hours into recovery.
Results
Plasma PTX3 concentrations significantly increased following HIIE, yet the PTX3 response to HIIE was significantly blunted in obese compared to normal-weight participants. While the kinetic responses of BAFMD were also significantly different in obese compared to normal-weight participants, similar increases above the baseline were observed 2 hours into recovery in both groups. Finally, plasma PTX3 concentrations were not associated with BAFMD at baseline or in response to HIIE.
Conclusion
The utilization of HIIE may serve as a time-efficient exercise prescription strategy to transiently improve endothelial function, independent of elevated plasma PTX3 concentrations, in obese individuals. |
| doi_str_mv | 10.1007/s00421-021-04632-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2494301235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2531421136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3385-12a0cb69ba9d94cbcc63117ef4c5ad8590e22c911673fa182276ee77bef48ab43</originalsourceid><addsrcrecordid>eNp9kb1OHDEQx60oKBwHL0CBLKWh2eCP_XKJUICTTkoDteX1znJGu_bG9p64jiKPwBPyJHh1hEgUKUYee37ztz1_hE4p-UEJqS4CITmjGZkjLznLii9oQXMusrSpvn7kVByioxAeCSE1o_U3dMh5yeuyFgv0ZzWMSkfsOqz0FAFvzMMmMzaCDSbu8Jz5reoxPIHXJgB2Fo-9CoPCI9jo1ZOxmGNlWwy2dXEDvUl4N1kdTWJT1TWQ-oxtzda0k-rD6_NL6ja9izjEqd0do4MuHcPJ-7pE99c_765us_Wvm9XV5TrTnNdFRpkiuilFo0Qrct1onf5GK-hyXai2LgQBxrSgtKx4p2jNWFUCVFWTiFo1OV-i873u6N3vCUKUgwka-l5ZcFOQLBc5J5TxIqHfP6GPbvI2vU6ygtM0d5pmuERsT2nvQvDQydGbQfmdpETOHsm9R5LMMXskZ-mzd-mpGaD9aPlrSgL4HgipZB_A_7v7P7JvlfOe-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2531421136</pqid></control><display><type>article</type><title>Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study</title><source>SpringerLink Journals</source><creator>Slusher, Aaron L. ; Fico, Brandon G. ; Dodge, Katelyn M. ; Garten, Ryan S. ; Ferrandi, Peter J. ; Rodriguez, Alexandra A. ; Pena, Gabriel ; Huang, Chun-Jung</creator><creatorcontrib>Slusher, Aaron L. ; Fico, Brandon G. ; Dodge, Katelyn M. ; Garten, Ryan S. ; Ferrandi, Peter J. ; Rodriguez, Alexandra A. ; Pena, Gabriel ; Huang, Chun-Jung</creatorcontrib><description>Purpose
Pentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intensity interval exercise (HIIE) has been demonstrated to be as effective as continuous moderate-intensity exercise in improving endothelial function, as indicated by brachial artery flow-mediated dilation (BAFMD), in patients with CVD. Therefore, the purpose of this study was to examine the effect of acute HIIE on plasma PTX3 and BAFMD responses in obese individuals.
Methods
Eight obese and six normal-weight young males participated in acute HIIE (4 intervals of 4 min at 80–90% of VO
2max
; 3 min of active recovery at 50–60% VO
2max
). Plasma PTX3 and BAFMD were measured prior to, immediately following exercise, and one and 2 hours into recovery.
Results
Plasma PTX3 concentrations significantly increased following HIIE, yet the PTX3 response to HIIE was significantly blunted in obese compared to normal-weight participants. While the kinetic responses of BAFMD were also significantly different in obese compared to normal-weight participants, similar increases above the baseline were observed 2 hours into recovery in both groups. Finally, plasma PTX3 concentrations were not associated with BAFMD at baseline or in response to HIIE.
Conclusion
The utilization of HIIE may serve as a time-efficient exercise prescription strategy to transiently improve endothelial function, independent of elevated plasma PTX3 concentrations, in obese individuals.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-021-04632-5</identifier><identifier>PMID: 33638689</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cardiovascular diseases ; Exercise ; Human Physiology ; Obesity ; Occupational Medicine/Industrial Medicine ; Original Article ; Pentraxins ; Plasma ; Sports Medicine</subject><ispartof>European journal of applied physiology, 2021-06, Vol.121 (6), p.1567-1577</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021. corrected publication 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021. corrected publication 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3385-12a0cb69ba9d94cbcc63117ef4c5ad8590e22c911673fa182276ee77bef48ab43</citedby><cites>FETCH-LOGICAL-c3385-12a0cb69ba9d94cbcc63117ef4c5ad8590e22c911673fa182276ee77bef48ab43</cites><orcidid>0000-0003-2082-4827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-021-04632-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-021-04632-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33638689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slusher, Aaron L.</creatorcontrib><creatorcontrib>Fico, Brandon G.</creatorcontrib><creatorcontrib>Dodge, Katelyn M.</creatorcontrib><creatorcontrib>Garten, Ryan S.</creatorcontrib><creatorcontrib>Ferrandi, Peter J.</creatorcontrib><creatorcontrib>Rodriguez, Alexandra A.</creatorcontrib><creatorcontrib>Pena, Gabriel</creatorcontrib><creatorcontrib>Huang, Chun-Jung</creatorcontrib><title>Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Pentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intensity interval exercise (HIIE) has been demonstrated to be as effective as continuous moderate-intensity exercise in improving endothelial function, as indicated by brachial artery flow-mediated dilation (BAFMD), in patients with CVD. Therefore, the purpose of this study was to examine the effect of acute HIIE on plasma PTX3 and BAFMD responses in obese individuals.
Methods
Eight obese and six normal-weight young males participated in acute HIIE (4 intervals of 4 min at 80–90% of VO
2max
; 3 min of active recovery at 50–60% VO
2max
). Plasma PTX3 and BAFMD were measured prior to, immediately following exercise, and one and 2 hours into recovery.
Results
Plasma PTX3 concentrations significantly increased following HIIE, yet the PTX3 response to HIIE was significantly blunted in obese compared to normal-weight participants. While the kinetic responses of BAFMD were also significantly different in obese compared to normal-weight participants, similar increases above the baseline were observed 2 hours into recovery in both groups. Finally, plasma PTX3 concentrations were not associated with BAFMD at baseline or in response to HIIE.
Conclusion
The utilization of HIIE may serve as a time-efficient exercise prescription strategy to transiently improve endothelial function, independent of elevated plasma PTX3 concentrations, in obese individuals.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiovascular diseases</subject><subject>Exercise</subject><subject>Human Physiology</subject><subject>Obesity</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Pentraxins</subject><subject>Plasma</subject><subject>Sports Medicine</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kb1OHDEQx60oKBwHL0CBLKWh2eCP_XKJUICTTkoDteX1znJGu_bG9p64jiKPwBPyJHh1hEgUKUYee37ztz1_hE4p-UEJqS4CITmjGZkjLznLii9oQXMusrSpvn7kVByioxAeCSE1o_U3dMh5yeuyFgv0ZzWMSkfsOqz0FAFvzMMmMzaCDSbu8Jz5reoxPIHXJgB2Fo-9CoPCI9jo1ZOxmGNlWwy2dXEDvUl4N1kdTWJT1TWQ-oxtzda0k-rD6_NL6ja9izjEqd0do4MuHcPJ-7pE99c_765us_Wvm9XV5TrTnNdFRpkiuilFo0Qrct1onf5GK-hyXai2LgQBxrSgtKx4p2jNWFUCVFWTiFo1OV-i873u6N3vCUKUgwka-l5ZcFOQLBc5J5TxIqHfP6GPbvI2vU6ygtM0d5pmuERsT2nvQvDQydGbQfmdpETOHsm9R5LMMXskZ-mzd-mpGaD9aPlrSgL4HgipZB_A_7v7P7JvlfOe-Q</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Slusher, Aaron L.</creator><creator>Fico, Brandon G.</creator><creator>Dodge, Katelyn M.</creator><creator>Garten, Ryan S.</creator><creator>Ferrandi, Peter J.</creator><creator>Rodriguez, Alexandra A.</creator><creator>Pena, Gabriel</creator><creator>Huang, Chun-Jung</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2082-4827</orcidid></search><sort><creationdate>20210601</creationdate><title>Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study</title><author>Slusher, Aaron L. ; Fico, Brandon G. ; Dodge, Katelyn M. ; Garten, Ryan S. ; Ferrandi, Peter J. ; Rodriguez, Alexandra A. ; Pena, Gabriel ; Huang, Chun-Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3385-12a0cb69ba9d94cbcc63117ef4c5ad8590e22c911673fa182276ee77bef48ab43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiovascular diseases</topic><topic>Exercise</topic><topic>Human Physiology</topic><topic>Obesity</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Pentraxins</topic><topic>Plasma</topic><topic>Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slusher, Aaron L.</creatorcontrib><creatorcontrib>Fico, Brandon G.</creatorcontrib><creatorcontrib>Dodge, Katelyn M.</creatorcontrib><creatorcontrib>Garten, Ryan S.</creatorcontrib><creatorcontrib>Ferrandi, Peter J.</creatorcontrib><creatorcontrib>Rodriguez, Alexandra A.</creatorcontrib><creatorcontrib>Pena, Gabriel</creatorcontrib><creatorcontrib>Huang, Chun-Jung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slusher, Aaron L.</au><au>Fico, Brandon G.</au><au>Dodge, Katelyn M.</au><au>Garten, Ryan S.</au><au>Ferrandi, Peter J.</au><au>Rodriguez, Alexandra A.</au><au>Pena, Gabriel</au><au>Huang, Chun-Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>121</volume><issue>6</issue><spage>1567</spage><epage>1577</epage><pages>1567-1577</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Pentraxin 3 (PTX3) has been shown to be a predictor of endothelial dysfunction in patients with increased risk of cardiovascular disease (CVD) (e.g., obesity). Circulating PTX3 concentrations are dysregulated in obese individuals and are elevated following acute aerobic exercise. High-intensity interval exercise (HIIE) has been demonstrated to be as effective as continuous moderate-intensity exercise in improving endothelial function, as indicated by brachial artery flow-mediated dilation (BAFMD), in patients with CVD. Therefore, the purpose of this study was to examine the effect of acute HIIE on plasma PTX3 and BAFMD responses in obese individuals.
Methods
Eight obese and six normal-weight young males participated in acute HIIE (4 intervals of 4 min at 80–90% of VO
2max
; 3 min of active recovery at 50–60% VO
2max
). Plasma PTX3 and BAFMD were measured prior to, immediately following exercise, and one and 2 hours into recovery.
Results
Plasma PTX3 concentrations significantly increased following HIIE, yet the PTX3 response to HIIE was significantly blunted in obese compared to normal-weight participants. While the kinetic responses of BAFMD were also significantly different in obese compared to normal-weight participants, similar increases above the baseline were observed 2 hours into recovery in both groups. Finally, plasma PTX3 concentrations were not associated with BAFMD at baseline or in response to HIIE.
Conclusion
The utilization of HIIE may serve as a time-efficient exercise prescription strategy to transiently improve endothelial function, independent of elevated plasma PTX3 concentrations, in obese individuals.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33638689</pmid><doi>10.1007/s00421-021-04632-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2082-4827</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Biomedical and Life Sciences Biomedicine Cardiovascular diseases Exercise Human Physiology Obesity Occupational Medicine/Industrial Medicine Original Article Pentraxins Plasma Sports Medicine |
| title | Impact of acute high-intensity interval exercise on plasma pentraxin 3 and endothelial function in obese individuals—a pilot study |
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