Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study
Objective To report the flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG) before and after successful surgical control of the intraocular pressure (IOP). Methods The study enrolled children presenting with PCG to the Ophthalmology Department of Alexandri...
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| Veröffentlicht in: | International ophthalmology 2021-06, Vol.41 (6), p.1981-1988 |
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| container_end_page | 1988 |
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| container_issue | 6 |
| container_start_page | 1981 |
| container_title | International ophthalmology |
| container_volume | 41 |
| creator | ElBahwash, Mai AbdelNabi Mohamed Morsy, Mahmoud Hassan Hegazy, Amira Saad Mahmoud Bayoumi, Nader Hussein Lotfy |
| description | Objective
To report the flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG) before and after successful surgical control of the intraocular pressure (IOP).
Methods
The study enrolled children presenting with PCG to the Ophthalmology Department of Alexandria Main University Hospital in the period between June and December 2019. All study participants were subjected to a standard protocol of examination, to confirm the diagnosis of PCG. The child was then referred for flash VEP testing. Peaks were designated as negative and positive waves in a numerical sequence (N1, P1, N2, P2, N3 and P3). The child was then scheduled for surgery within 1 week of presentation. Postoperative VEP testing was scheduled as soon as feasible and was conducted in the same way as the preoperative VEP testing.
Results
The study was conducted on 11 (four right) eyes of eight (five males) children. The mean ± standard deviation of the age of the study children at presentation and at postoperative VEP testing was 3.5 ± 1.6 and 5.1 ± 3.0 months, respectively. The study eyes mean ± standard deviation IOP at presentation and at postoperative VEP testing was 23.0 ± 6.7 and 8.3 ± 2.4 mmHg, respectively (
p
|
| doi_str_mv | 10.1007/s10792-021-01753-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2494297454</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2536110172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-1a471264320760848f6a0f3e54dd63cb5c435275a46b1276bd3cb729ac701bf43</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EouXyAgzIEgtLwHc3bKjiJlViARYGy3GcNiWJQ-xQ9e1xSQGJgcmWz3f-4_MBcILRBUZIXnqMZEoSRHCCsOQ0We2AMeaSJkRQtAvGCAuecInwCBx4v0QIpTIV-2BEqaCcTdIxeH0pfa8raD_cm81h64JtQqkrD81CN3Pr4aoMC-j7bm67NSwb2HZlrePVuFhuyhCb55Xujav1FdSwLSsXoA99vj4Ce0VMssfb8xA83948Te-T2ePdw_R6lhhKREiwZhITwShBUqAJmxRCo4JazvJcUJNxwygnkmsmMkykyPL4KEmqTdwsKxg9BOdDbtu59976oOrSG1tVurGu94qwlJFUMr5Bz_6gS9d3TfydIpwKjKNIEikyUKZz3ne2UNulFUZqo14N6lVUr77Uq1VsOt1G91lt85-Wb9cRoAPgYym6635n_xP7CcIjjs0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2536110172</pqid></control><display><type>article</type><title>Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study</title><source>SpringerLink Journals - AutoHoldings</source><creator>ElBahwash, Mai AbdelNabi Mohamed ; Morsy, Mahmoud Hassan ; Hegazy, Amira Saad Mahmoud ; Bayoumi, Nader Hussein Lotfy</creator><creatorcontrib>ElBahwash, Mai AbdelNabi Mohamed ; Morsy, Mahmoud Hassan ; Hegazy, Amira Saad Mahmoud ; Bayoumi, Nader Hussein Lotfy</creatorcontrib><description>Objective
To report the flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG) before and after successful surgical control of the intraocular pressure (IOP).
Methods
The study enrolled children presenting with PCG to the Ophthalmology Department of Alexandria Main University Hospital in the period between June and December 2019. All study participants were subjected to a standard protocol of examination, to confirm the diagnosis of PCG. The child was then referred for flash VEP testing. Peaks were designated as negative and positive waves in a numerical sequence (N1, P1, N2, P2, N3 and P3). The child was then scheduled for surgery within 1 week of presentation. Postoperative VEP testing was scheduled as soon as feasible and was conducted in the same way as the preoperative VEP testing.
Results
The study was conducted on 11 (four right) eyes of eight (five males) children. The mean ± standard deviation of the age of the study children at presentation and at postoperative VEP testing was 3.5 ± 1.6 and 5.1 ± 3.0 months, respectively. The study eyes mean ± standard deviation IOP at presentation and at postoperative VEP testing was 23.0 ± 6.7 and 8.3 ± 2.4 mmHg, respectively (
p
< 0.0001). There were a statistically insignificant reduction in P2 implicit time (
p
= 0.235) and a statistically insignificant increase in each of N1–P1 (
p
= 0.15) and N2–P2 (
p
= 0.67) amplitudes postoperatively than preoperatively.
Conclusions
IOP elevation in PCG adversely affects the optic nerve function, but, at least in the short term, has no permanent detrimental effect on the optic nerve function as evidenced by the improvement in the VEP parameters.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-01753-w</identifier><identifier>PMID: 33635489</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Auditory evoked potentials ; Children ; Eye (anatomy) ; Glaucoma ; Intraocular pressure ; Medicine ; Medicine & Public Health ; Ophthalmology ; Optic nerve ; Original Paper ; Standard deviation ; Surgery ; Visual evoked potentials</subject><ispartof>International ophthalmology, 2021-06, Vol.41 (6), p.1981-1988</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-1a471264320760848f6a0f3e54dd63cb5c435275a46b1276bd3cb729ac701bf43</cites><orcidid>0000-0002-3140-5073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-021-01753-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-021-01753-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33635489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ElBahwash, Mai AbdelNabi Mohamed</creatorcontrib><creatorcontrib>Morsy, Mahmoud Hassan</creatorcontrib><creatorcontrib>Hegazy, Amira Saad Mahmoud</creatorcontrib><creatorcontrib>Bayoumi, Nader Hussein Lotfy</creatorcontrib><title>Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Objective
To report the flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG) before and after successful surgical control of the intraocular pressure (IOP).
Methods
The study enrolled children presenting with PCG to the Ophthalmology Department of Alexandria Main University Hospital in the period between June and December 2019. All study participants were subjected to a standard protocol of examination, to confirm the diagnosis of PCG. The child was then referred for flash VEP testing. Peaks were designated as negative and positive waves in a numerical sequence (N1, P1, N2, P2, N3 and P3). The child was then scheduled for surgery within 1 week of presentation. Postoperative VEP testing was scheduled as soon as feasible and was conducted in the same way as the preoperative VEP testing.
Results
The study was conducted on 11 (four right) eyes of eight (five males) children. The mean ± standard deviation of the age of the study children at presentation and at postoperative VEP testing was 3.5 ± 1.6 and 5.1 ± 3.0 months, respectively. The study eyes mean ± standard deviation IOP at presentation and at postoperative VEP testing was 23.0 ± 6.7 and 8.3 ± 2.4 mmHg, respectively (
p
< 0.0001). There were a statistically insignificant reduction in P2 implicit time (
p
= 0.235) and a statistically insignificant increase in each of N1–P1 (
p
= 0.15) and N2–P2 (
p
= 0.67) amplitudes postoperatively than preoperatively.
Conclusions
IOP elevation in PCG adversely affects the optic nerve function, but, at least in the short term, has no permanent detrimental effect on the optic nerve function as evidenced by the improvement in the VEP parameters.</description><subject>Auditory evoked potentials</subject><subject>Children</subject><subject>Eye (anatomy)</subject><subject>Glaucoma</subject><subject>Intraocular pressure</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Original Paper</subject><subject>Standard deviation</subject><subject>Surgery</subject><subject>Visual evoked potentials</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kLtOwzAUhi0EouXyAgzIEgtLwHc3bKjiJlViARYGy3GcNiWJQ-xQ9e1xSQGJgcmWz3f-4_MBcILRBUZIXnqMZEoSRHCCsOQ0We2AMeaSJkRQtAvGCAuecInwCBx4v0QIpTIV-2BEqaCcTdIxeH0pfa8raD_cm81h64JtQqkrD81CN3Pr4aoMC-j7bm67NSwb2HZlrePVuFhuyhCb55Xujav1FdSwLSsXoA99vj4Ce0VMssfb8xA83948Te-T2ePdw_R6lhhKREiwZhITwShBUqAJmxRCo4JazvJcUJNxwygnkmsmMkykyPL4KEmqTdwsKxg9BOdDbtu59976oOrSG1tVurGu94qwlJFUMr5Bz_6gS9d3TfydIpwKjKNIEikyUKZz3ne2UNulFUZqo14N6lVUr77Uq1VsOt1G91lt85-Wb9cRoAPgYym6635n_xP7CcIjjs0</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>ElBahwash, Mai AbdelNabi Mohamed</creator><creator>Morsy, Mahmoud Hassan</creator><creator>Hegazy, Amira Saad Mahmoud</creator><creator>Bayoumi, Nader Hussein Lotfy</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3140-5073</orcidid></search><sort><creationdate>20210601</creationdate><title>Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study</title><author>ElBahwash, Mai AbdelNabi Mohamed ; Morsy, Mahmoud Hassan ; Hegazy, Amira Saad Mahmoud ; Bayoumi, Nader Hussein Lotfy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-1a471264320760848f6a0f3e54dd63cb5c435275a46b1276bd3cb729ac701bf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Auditory evoked potentials</topic><topic>Children</topic><topic>Eye (anatomy)</topic><topic>Glaucoma</topic><topic>Intraocular pressure</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Original Paper</topic><topic>Standard deviation</topic><topic>Surgery</topic><topic>Visual evoked potentials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ElBahwash, Mai AbdelNabi Mohamed</creatorcontrib><creatorcontrib>Morsy, Mahmoud Hassan</creatorcontrib><creatorcontrib>Hegazy, Amira Saad Mahmoud</creatorcontrib><creatorcontrib>Bayoumi, Nader Hussein Lotfy</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ElBahwash, Mai AbdelNabi Mohamed</au><au>Morsy, Mahmoud Hassan</au><au>Hegazy, Amira Saad Mahmoud</au><au>Bayoumi, Nader Hussein Lotfy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>41</volume><issue>6</issue><spage>1981</spage><epage>1988</epage><pages>1981-1988</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Objective
To report the flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG) before and after successful surgical control of the intraocular pressure (IOP).
Methods
The study enrolled children presenting with PCG to the Ophthalmology Department of Alexandria Main University Hospital in the period between June and December 2019. All study participants were subjected to a standard protocol of examination, to confirm the diagnosis of PCG. The child was then referred for flash VEP testing. Peaks were designated as negative and positive waves in a numerical sequence (N1, P1, N2, P2, N3 and P3). The child was then scheduled for surgery within 1 week of presentation. Postoperative VEP testing was scheduled as soon as feasible and was conducted in the same way as the preoperative VEP testing.
Results
The study was conducted on 11 (four right) eyes of eight (five males) children. The mean ± standard deviation of the age of the study children at presentation and at postoperative VEP testing was 3.5 ± 1.6 and 5.1 ± 3.0 months, respectively. The study eyes mean ± standard deviation IOP at presentation and at postoperative VEP testing was 23.0 ± 6.7 and 8.3 ± 2.4 mmHg, respectively (
p
< 0.0001). There were a statistically insignificant reduction in P2 implicit time (
p
= 0.235) and a statistically insignificant increase in each of N1–P1 (
p
= 0.15) and N2–P2 (
p
= 0.67) amplitudes postoperatively than preoperatively.
Conclusions
IOP elevation in PCG adversely affects the optic nerve function, but, at least in the short term, has no permanent detrimental effect on the optic nerve function as evidenced by the improvement in the VEP parameters.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>33635489</pmid><doi>10.1007/s10792-021-01753-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3140-5073</orcidid></addata></record> |
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| ispartof | International ophthalmology, 2021-06, Vol.41 (6), p.1981-1988 |
| issn | 0165-5701 1573-2630 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Auditory evoked potentials Children Eye (anatomy) Glaucoma Intraocular pressure Medicine Medicine & Public Health Ophthalmology Optic nerve Original Paper Standard deviation Surgery Visual evoked potentials |
| title | Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study |
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