Shulin packages axonemal outer dynein arms for ciliary targeting

The main force generators in eukaryotic cilia and flagella are axonemal outer dynein arms (ODAs). During ciliogenesis, these similar to 1.8-megadalton complexes are assembled in the cytoplasm and targeted to cilia by an unknown mechanism. Here, we used the ciliate Tetrahymena to identify two factors...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-02, Vol.371 (6532), p.910-916
Hauptverfasser:	Mali, Girish R., Ali, Ferdos Abid, Lau, Clinton K., Begum, Farida, Boulanger, Jerome, Howe, Jonathan D., Chen, Zhuo A., Rappsilber, Juri, Skehel, Mark, Carter, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Axonemal Dyneins - chemistry Axonemal Dyneins - genetics Axonemal Dyneins - metabolism C-Terminus Cell body Chains Cilia Cilia - metabolism Clearing Compacts Computational fluid dynamics Cryoelectron Microscopy Cytoplasm Cytoplasm - metabolism Domains Dynein Electron microscopy Eukaryotes Flagella Gene Knockdown Techniques Generators Histones Homology Image Processing, Computer-Assisted Inhibition Mass spectrometry Mass spectroscopy Microscopy Microtubules Microtubules - physiology Models, Molecular Molecular motors Motor activity Movement Mucus Multidisciplinary Sciences Organelles Primary ciliary dyskinesia Protein Binding Protein Conformation Protein Domains Protozoa Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Regulators Respiratory diseases Science & Technology Science & Technology - Other Topics Swimming Synthesis Tails Tetrahymena Tetrahymena thermophila - genetics Tetrahymena thermophila - physiology Triphosphatase
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