High Mobility Group Box Chromosomal Protein-1 Induces Myofibroblast Differentiation and Extracellular Matrix Production via RAGE, p38, JNK and AP-1 Signaling Pathways in Nasal Fibroblasts

Background Chronic rhinosinusitis is involved in myofibroblast differentiation and extracellular matrix (ECM) accumulation. High mobility group box chromosomal protein 1 (HMGB-1) is known to stimulate lung fibroblast to produce ECM in lung fibrosis. The aim of this study was to investigate whether H...

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Veröffentlicht in:	American journal of rhinology & allergy 2021-11, Vol.35 (6), p.774-780
Hauptverfasser:	Lee, Soo-Hyung, Cho, Jae Hoon, Park, Joo-Hoo, Cho, Jung-Sun, Lee, Heung-Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Cell Differentiation Cells, Cultured Collagen - metabolism Extracellular Matrix - metabolism Fibroblasts - metabolism Fibronectins - metabolism HMGB1 Protein - genetics Humans Myofibroblasts - cytology Signal Transduction Transcription Factor AP-1
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