Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis
The balance of osteoblasts and marrow adipocytes from bone marrow mesenchymal stem cells (BM-MSCs) maintains bone health. Under aging or other pathological stimuli, BM-MSCs will preferentially differentiate into marrow adipocytes and reduce osteoblasts, leading to osteoporosis. Long non-coding RNA d...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2021-06, Vol.476 (6), p.2503-2512 |
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| creator | Weng, Wei Di, Shengdi Xing, Shitong Sun, Zhengguo Shen, Zheyuan Dou, Xiaojie He, Shouyu Tang, Huibin Min, Jikang |
| description | The balance of osteoblasts and marrow adipocytes from bone marrow mesenchymal stem cells (BM-MSCs) maintains bone health. Under aging or other pathological stimuli, BM-MSCs will preferentially differentiate into marrow adipocytes and reduce osteoblasts, leading to osteoporosis. Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) participates in the osteogenic differentiation of human BM-MSCs, but the mechanism by which DANCR regulates the osteogenic differentiation of human BM-MSCs has not been fully explained. We observed that DANCR and prospero homeobox 1 (PROX1) were downregulated during osteogenic differentiation of human BM-MSCs, while miR-1301-3p had an opposite trend. DANCR overexpression decreased the levels of alkaline phosphatase, RUNX2, osteocalcin, Osterix in BM-MSCs after osteogenic induction, but DANCR silencing had the opposite result. Moreover, DANCR sponged miR-1301-3p to regulate PROX1 expression. miR-1301-3p overexpression reversed the suppressive role of DANCR elevation on the osteogenic differentiation of human BM-MSCs. Also, PROX1 elevation abolished the promoting role of miR-1301-3p overexpression on the osteogenic differentiation of human BM-MSCs. In conclusion, DANCR suppressed the osteogenic differentiation of human BM-MSCs through the miR-1301-3p/PROX1 axis, offering a novel mechanism by which DANCR is responsible for the osteogenic differentiation of human BM-MSCs. |
| doi_str_mv | 10.1007/s11010-021-04074-9 |
| format | Article |
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Under aging or other pathological stimuli, BM-MSCs will preferentially differentiate into marrow adipocytes and reduce osteoblasts, leading to osteoporosis. Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) participates in the osteogenic differentiation of human BM-MSCs, but the mechanism by which DANCR regulates the osteogenic differentiation of human BM-MSCs has not been fully explained. We observed that DANCR and prospero homeobox 1 (PROX1) were downregulated during osteogenic differentiation of human BM-MSCs, while miR-1301-3p had an opposite trend. DANCR overexpression decreased the levels of alkaline phosphatase, RUNX2, osteocalcin, Osterix in BM-MSCs after osteogenic induction, but DANCR silencing had the opposite result. Moreover, DANCR sponged miR-1301-3p to regulate PROX1 expression. miR-1301-3p overexpression reversed the suppressive role of DANCR elevation on the osteogenic differentiation of human BM-MSCs. Also, PROX1 elevation abolished the promoting role of miR-1301-3p overexpression on the osteogenic differentiation of human BM-MSCs. In conclusion, DANCR suppressed the osteogenic differentiation of human BM-MSCs through the miR-1301-3p/PROX1 axis, offering a novel mechanism by which DANCR is responsible for the osteogenic differentiation of human BM-MSCs.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04074-9</identifier><identifier>PMID: 33629241</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adipocytes ; Aging ; Alkaline phosphatase ; Biochemistry ; Biomedical and Life Sciences ; Biomedical materials ; Bone marrow ; Cardiology ; Cbfa-1 protein ; Cell Biology ; Differentiation (biology) ; Homeobox ; Life Sciences ; Life Sciences & Biomedicine ; Medical Biochemistry ; Mesenchyme ; Neomycin ; Non-coding RNA ; Oncology ; Osteoblastogenesis ; Osteoblasts ; Osteocalcin ; Osteoporosis ; Prospero protein ; RNA ; Science & Technology ; Stem cells</subject><ispartof>Molecular and cellular biochemistry, 2021-06, Vol.476 (6), p.2503-2512</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000621287500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c442t-86e77034601ae8a46e3da4aab134bf46d15441a01a4133ee6fdd7bf44e895b123</citedby><cites>FETCH-LOGICAL-c442t-86e77034601ae8a46e3da4aab134bf46d15441a01a4133ee6fdd7bf44e895b123</cites><orcidid>0000-0002-9149-5795</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-021-04074-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-021-04074-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33629241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weng, Wei</creatorcontrib><creatorcontrib>Di, Shengdi</creatorcontrib><creatorcontrib>Xing, Shitong</creatorcontrib><creatorcontrib>Sun, Zhengguo</creatorcontrib><creatorcontrib>Shen, Zheyuan</creatorcontrib><creatorcontrib>Dou, Xiaojie</creatorcontrib><creatorcontrib>He, Shouyu</creatorcontrib><creatorcontrib>Tang, Huibin</creatorcontrib><creatorcontrib>Min, Jikang</creatorcontrib><title>Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>MOL CELL BIOCHEM</addtitle><addtitle>Mol Cell Biochem</addtitle><description>The balance of osteoblasts and marrow adipocytes from bone marrow mesenchymal stem cells (BM-MSCs) maintains bone health. Under aging or other pathological stimuli, BM-MSCs will preferentially differentiate into marrow adipocytes and reduce osteoblasts, leading to osteoporosis. Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) participates in the osteogenic differentiation of human BM-MSCs, but the mechanism by which DANCR regulates the osteogenic differentiation of human BM-MSCs has not been fully explained. We observed that DANCR and prospero homeobox 1 (PROX1) were downregulated during osteogenic differentiation of human BM-MSCs, while miR-1301-3p had an opposite trend. DANCR overexpression decreased the levels of alkaline phosphatase, RUNX2, osteocalcin, Osterix in BM-MSCs after osteogenic induction, but DANCR silencing had the opposite result. Moreover, DANCR sponged miR-1301-3p to regulate PROX1 expression. miR-1301-3p overexpression reversed the suppressive role of DANCR elevation on the osteogenic differentiation of human BM-MSCs. Also, PROX1 elevation abolished the promoting role of miR-1301-3p overexpression on the osteogenic differentiation of human BM-MSCs. In conclusion, DANCR suppressed the osteogenic differentiation of human BM-MSCs through the miR-1301-3p/PROX1 axis, offering a novel mechanism by which DANCR is responsible for the osteogenic differentiation of human BM-MSCs.</description><subject>Adipocytes</subject><subject>Aging</subject><subject>Alkaline phosphatase</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>Bone marrow</subject><subject>Cardiology</subject><subject>Cbfa-1 protein</subject><subject>Cell Biology</subject><subject>Differentiation (biology)</subject><subject>Homeobox</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical Biochemistry</subject><subject>Mesenchyme</subject><subject>Neomycin</subject><subject>Non-coding RNA</subject><subject>Oncology</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts</subject><subject>Osteocalcin</subject><subject>Osteoporosis</subject><subject>Prospero protein</subject><subject>RNA</subject><subject>Science & Technology</subject><subject>Stem 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Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weng, Wei</au><au>Di, Shengdi</au><au>Xing, Shitong</au><au>Sun, Zhengguo</au><au>Shen, Zheyuan</au><au>Dou, Xiaojie</au><au>He, Shouyu</au><au>Tang, Huibin</au><au>Min, Jikang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><stitle>MOL CELL BIOCHEM</stitle><addtitle>Mol Cell Biochem</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>476</volume><issue>6</issue><spage>2503</spage><epage>2512</epage><pages>2503-2512</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The balance of osteoblasts and marrow adipocytes from bone marrow mesenchymal stem cells (BM-MSCs) maintains bone health. Under aging or other pathological stimuli, BM-MSCs will preferentially differentiate into marrow adipocytes and reduce osteoblasts, leading to osteoporosis. Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) participates in the osteogenic differentiation of human BM-MSCs, but the mechanism by which DANCR regulates the osteogenic differentiation of human BM-MSCs has not been fully explained. We observed that DANCR and prospero homeobox 1 (PROX1) were downregulated during osteogenic differentiation of human BM-MSCs, while miR-1301-3p had an opposite trend. DANCR overexpression decreased the levels of alkaline phosphatase, RUNX2, osteocalcin, Osterix in BM-MSCs after osteogenic induction, but DANCR silencing had the opposite result. Moreover, DANCR sponged miR-1301-3p to regulate PROX1 expression. miR-1301-3p overexpression reversed the suppressive role of DANCR elevation on the osteogenic differentiation of human BM-MSCs. Also, PROX1 elevation abolished the promoting role of miR-1301-3p overexpression on the osteogenic differentiation of human BM-MSCs. In conclusion, DANCR suppressed the osteogenic differentiation of human BM-MSCs through the miR-1301-3p/PROX1 axis, offering a novel mechanism by which DANCR is responsible for the osteogenic differentiation of human BM-MSCs.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33629241</pmid><doi>10.1007/s11010-021-04074-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9149-5795</orcidid></addata></record> |
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| subjects | Adipocytes Aging Alkaline phosphatase Biochemistry Biomedical and Life Sciences Biomedical materials Bone marrow Cardiology Cbfa-1 protein Cell Biology Differentiation (biology) Homeobox Life Sciences Life Sciences & Biomedicine Medical Biochemistry Mesenchyme Neomycin Non-coding RNA Oncology Osteoblastogenesis Osteoblasts Osteocalcin Osteoporosis Prospero protein RNA Science & Technology Stem cells |
| title | Long non-coding RNA DANCR modulates osteogenic differentiation by regulating the miR-1301-3p/PROX1 axis |
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