Synthesis of Enynic and Allenic Orthoesters via Defluoromethoxylation of 2‑Trifluoromethyl-1,3-enynes

Synthesis of Enynic and Allenic Orthoesters via Defluoromethoxylation of 2‑Trifluoromethyl-1,3-enynes

In this protocol, the chemoselective defluoromethoxylation reactions of 2-trifluoromethyl-1,3-enynes were developed. The enynic and allenic orthoesters were selectively produced in good to excellent yields via multiple substitution processes under mild reaction conditions, respectively. The enynic o...

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Veröffentlicht in:Organic letters 2021-03, Vol.23 (5), p.1898-1903
Hauptverfasser: Dai, Dong-Ting, Xu, Jian-Lin, Chen, Zhi-Yuan, Wang, Zi-Lu, Xu, Yun-He
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container_end_page 1903
container_issue 5
container_start_page 1898
container_title Organic letters
container_volume 23
creator Dai, Dong-Ting
Xu, Jian-Lin
Chen, Zhi-Yuan
Wang, Zi-Lu
Xu, Yun-He
description In this protocol, the chemoselective defluoromethoxylation reactions of 2-trifluoromethyl-1,3-enynes were developed. The enynic and allenic orthoesters were selectively produced in good to excellent yields via multiple substitution processes under mild reaction conditions, respectively. The enynic orthoester products were proved capable of acting as efficient “platform molecules” to access various functionalized allenyl compounds.
doi_str_mv 10.1021/acs.orglett.1c00311
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title Synthesis of Enynic and Allenic Orthoesters via Defluoromethoxylation of 2‑Trifluoromethyl-1,3-enynes
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