Programming changes of hippocampal miR-134-5p/SOX2 signal mediate the susceptibility to depression in prenatal dexamethasone-exposed female offspring

Depression is a neuropsychiatric disorder and has intrauterine developmental origins. This study aimed to confirm the depression susceptibility in offspring rats induced by prenatal dexamethasone exposure (PDE) and to further explore the intrauterine programming mechanism. Wistar rats were injected...

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Veröffentlicht in:	Cell biology and toxicology 2022-02, Vol.38 (1), p.69-86
Hauptverfasser:	Jiang, Tao, Hu, Shuwei, Dai, Shiyun, Yi, Yiwen, Wang, Tingting, Li, Xufeng, Luo, Mingcui, Li, Ke, Chen, Liaobin, Wang, Hui, Xu, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Cell Biology Cell proliferation Cells (biology) Dexamethasone Disorders Epigenetics Fetuses Glucocorticoids Hippocampus Life Sciences Mental depression Mental disorders Neural stem cells Neurogenesis Offspring Original Article Pharmacology/Toxicology Prenatal experience Progenitor cells Programming Receptors SIRT1 protein Steroids
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